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Method for preparing gold nanoparticles

A nano-gold and particle technology, which is applied in the field of preparation of nano-gold particles, can solve problems such as long technical time, shortened preparation cycle, and product stability to be improved, so as to reduce adverse effects, accurately control particle size distribution, and heat evenly and quickly Effect

Inactive Publication Date: 2011-01-05
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is: Based on the problems that the existing nano-gold preparation technology takes a long time and the product stability needs to be improved, the present invention provides a microwave-assisted preparation method of nano-gold using a composite polymer compound as a protective agent, which uses microwave heating to quickly The homogeneous feature shortens the product preparation cycle, and at the same time utilizes the synergistic protective effect of the organic polymer protective agent polyvinylpyrrolidone and polyethylene glycol, and the particle size control effect of cetyltrimethylammonium bromide , to achieve rapid preparation of gold nanoparticles with uniform and controllable particle size

Method used

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Experimental program
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Effect test

Embodiment 1

[0025] Add 100 mL of chloroauric acid solution with a concentration of 100 μg / mL into a three-neck flask, add 10 mL of polyvinylpyrrolidone solution, and 10 mL of polyethylene glycol solution. Put the three-neck flask into a microwave reactor for reaction, set the microwave power to 650W, and the solution boils after 1.5 minutes. Quickly add 2 mL of sodium citrate solution with a concentration of 0.02 g / mL, continue the microwave reaction under stirring at 300 r / min, the microwave power is 325 W, and stop the reaction after 5 minutes. After the reaction was completed, 10 mL of cetyltrimethylammonium bromide solution was added to terminate the reaction. Finally, the reaction solution was centrifuged at a low speed of 1000r / min by a high-speed centrifuge, and the supernatant was then centrifuged at a high speed of 11000r / min, and the lower sediment was washed with twice distilled water to obtain a product with a particle size of 15nm.

Embodiment 2

[0027] Add 100 mL of chloroauric acid solution with a concentration of 100 μg / mL into a three-neck flask, add 10 mL of polyvinylpyrrolidone solution, and 10 mL of polyethylene glycol solution. Put the three-neck flask into a microwave reactor for reaction, set the microwave power to 650W, and the solution boils after 1.5 minutes. Quickly add 4 mL of sodium citrate solution with a concentration of 0.02 g / mL, continue the microwave reaction under stirring at 200 r / min, the microwave power is 390 W, and stop the reaction after 6 minutes. After the reaction was completed, 10 mL of cetyltrimethylammonium bromide solution was added to terminate the reaction. Finally, the reaction solution was centrifuged at a low speed of 1000r / min by a high-speed centrifuge, and the supernatant was then centrifuged at a high speed of 11000r / min, and the lower sediment was washed with double distilled water to obtain a product with a particle size of 40nm.

Embodiment 3

[0029] Add 100 mL of chloroauric acid solution with a concentration of 100 μg / mL into a three-neck flask, add 10 mL of polyvinylpyrrolidone solution, and 10 mL of polyethylene glycol solution. Put the three-neck flask into a microwave reactor for reaction, set the microwave power to 650W, and the solution boils after 1.5 minutes. Quickly add 1 mL of sodium citrate solution with a concentration of 0.02 g / mL, continue the microwave reaction under stirring at 100 r / min, the microwave power is 325 W, and stop the reaction after 8 minutes. After the reaction was completed, 20 mL of cetyltrimethylammonium bromide solution was added to terminate the reaction. Finally, the reaction solution was centrifuged at a low speed of 1000r / min by a high-speed centrifuge, and the supernatant was then centrifuged at a high speed of 11000r / min, and the lower sediment was washed with twice distilled water to obtain a product with a particle size of 60nm.

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Abstract

The invention discloses a method for preparing gold nanoparticles by using compound high-molecular protective agents under the action of microwaves, comprising the following steps of: mixing polyvinylpyrrolidone and a polyethylene glycol compound protective agent with a chloroauric acid solution; fast reducing the chloroauric acid solution into the gold nanoparticles by taking sodium citrate as a reductant in a microwave reactor; after microwave reaction is finished, adding hexadecyl trimethyl ammonium bromide to prevent the growth of the gold nanoparticles; separating finial products, and then washing by using water so as to obtain spherical gold nanoparticles with grain diameters between 15 nanometers and 60 nanometers and intensively distributed. The gold nanoparticles obtained by taking the polyvinylpyrrolidone and the polyethylene glycol as the compound high-molecular protective agents have uniform grain diameter and good product stability; in the invention, the whole preparation process of the gold nanoparticles through a microwave method only needs less than 20 minutes, thereby enhancing the reaction rate and providing a new way for the preparation of the gold nanoparticles; and in addition, the prepared gold nanoparticles can be used for biomedical detection and biochemical products.

Description

technical field [0001] The invention belongs to the technical field of nano-metal material preparation, and relates to a preparation method of nano-gold particles using a composite polymer compound as a protective agent and using microwaves as a heating means. Background technique [0002] The rapid development of nanotechnology has opened up new directions for the application of nanoparticles in life science and bioanalysis. Due to their unique physical and chemical properties, nanoparticles have attracted great attention of scientists, and their applications in chemical and biological sensing are also increasing. [0003] Gold nanoparticles have shown great application value in many fields due to their good stability, small size effect, surface effect, optical effect and unique biological affinity. It has been an important research hotspot to prepare gold nanoparticles with good monodispersity, controllable particle size and high uniformity by a simple method. [0004] D...

Claims

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Application Information

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IPC IPC(8): B22F9/24
Inventor 陈晓青向娟刘亮亮陈胜华
Owner CENT SOUTH UNIV
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