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Itraconazole gel for dogs and preparation method thereof

An itraconazole gel and the technology of itraconazole are applied in the field of itraconazole gel for dogs and its preparation, which can solve the problems of long treatment process, large dosage, skin damage, etc., and achieve good therapeutic effect, Small toxic and side effects, non-toxic effect on the skin

Inactive Publication Date: 2010-11-24
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Itraconazole (Itraconazole) is a triazole broad-spectrum antifungal drug developed by Johnson & Johnson of the United States. It is an extremely water-soluble drug and an antifungal drug. However, due to the obstinacy of dermatophytosis, the treatment process is relatively long, and the systemic administration dose is too large, resulting in side effects such as skin damage, gastrointestinal reactions, and liver damage, and the cost is relatively high; The use of intramuscular injections is mainly based on the use of itraconazole capsules for humans by veterinary clinicians in China for dogs with fungal diseases according to different situations. There is no gel formulation for dogs, so it is prepared for external use. Dosage form, used to treat superficial fungal infections, not only can reduce the dosage, reduce toxic and side effects, but also reduce drug costs, and can treat skin fungal infections in a targeted manner

Method used

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  • Itraconazole gel for dogs and preparation method thereof
  • Itraconazole gel for dogs and preparation method thereof
  • Itraconazole gel for dogs and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Accurately weigh 1.5g of itraconazole, add absolute ethanol to the Erlenmeyer flask, and add concentrated hydrochloric acid dropwise under magnetic stirring to completely dissolve to a transparent liquid; then weigh 52.5g of hydroxypropyl-β-cyclodextrin, Add distilled water to dissolve in a water bath at 60°C to obtain a hydroxypropyl-β-cyclodextrin solution; slowly add the hydroxypropyl-β-cyclodextrin solution to the itraconazole acidic solution under magnetic stirring, dropwise The time is 30 minutes, 24 hours at 40°C to obtain the clathrate solution; another 1.5 g of Carbomer 940 is weighed and placed in a small beaker, spread evenly, spray an appropriate amount of distilled water with a sprayer, and swell for 24 hours to obtain translucent jelly-like object; add ethylene glycol-400 10g, salicylic acid 6g and ethylparaben 0.1g to the swollen carbomer 940 and stir evenly, then slowly add the clathrate solution to the gel , stir until there is no clot, add an appropria...

Embodiment 2

[0018] Accurately weigh 3.0g of itraconazole, add absolute ethanol to the Erlenmeyer flask, and add concentrated hydrochloric acid dropwise under magnetic stirring to completely dissolve to a transparent liquid; then weigh 105.0g of hydroxypropyl-β-cyclodextrin, Add distilled water to dissolve in a water bath at 60°C to obtain a hydroxypropyl-β-cyclodextrin solution; slowly add the hydroxypropyl-β-cyclodextrin solution to the itraconazole acidic solution under magnetic stirring, dropwise The time is 60 minutes, 24 hours at 40°C to obtain the clathrate solution; another 3.0 g of Carbomer 940 is weighed and placed in a small beaker, spread evenly, spray an appropriate amount of distilled water with a sprayer, and swell for 24 hours to obtain translucent jelly-like object; add 20g of ethylene glycol-400, 12.0g of salicylic acid and 0.2g of ethylparaben to the swollen carbomer 940 and stir evenly, then slowly add the clathrate solution dropwise to the condensed In the glue, stir e...

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Abstract

The invention relates to an itraconazole gel for dogs and a preparation method thereof, belonging to animal medicines. The gel consists of itraconazole, hydroxypropyl-beta-cyclodextrin, carbomer 940, salicylic acid, polyethylene glycol-400, ethylparaben, absolute ethyl alcohol, concentrated hydrochloric acid, distilled water and triethanolamine. The preparation method comprises the following steps: preparing an itraconazole inclusion compound solution by a hydroxypropyl-beta-cyclodextrin inclusion technology; preparing the gel substrate from the carbomer 940, the salicylic acid, the polyethylene glycol-400, the ethylparaben and the distilled water; mixing and stirring the inclusion compound solution and the gel substrate evenly; regulating the pH value; and carrying out circulating steam sterilization to obtain the itraconazole gel. The finished product of the gel prepared by the invention is faint yellow, transparent and even, and has stable characters and good medicine penetrating effect, the content meets a criterion, the content of medicine in skin is higher, the bacteriostasis effect and the clinic curative effect are superior to that of general external antifungal agents, and the itraconazole gel has the characteristics of no stimulation, no toxicity, weak sensitization, safety and high efficiency.

Description

technical field [0001] The invention belongs to veterinary medicine and preparation technology, in particular to an itraconazole gel for dogs and a preparation method thereof. Background technique [0002] Itraconazole (Itraconazole) is a triazole broad-spectrum antifungal drug developed by Johnson & Johnson of the United States. It is an extremely water-soluble drug and an antifungal drug. However, due to the obstinacy of dermatophytosis, the treatment process is relatively long, and the systemic administration dose is too large, resulting in side effects such as skin damage, gastrointestinal reactions, and liver damage, and the cost is relatively high; The use of intramuscular injections is mainly based on the use of itraconazole capsules for humans by veterinary clinicians in China for dogs with fungal diseases according to different situations. There is no gel formulation for dogs, so it is prepared for external use. The dosage form is used for treating superficial fung...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/496A61K47/32A61P31/10
Inventor 刘云陈曦陈亮
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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