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Acute turpinia leaf general flavone ethanol reflux extract, and preparation method and application thereof

A percolation extraction technology for the round leaves of Shanxiang, which is applied in the field of ethanol percolation extract of total flavonoids of Shanxiang and its preparation, can solve the problems of high price, and achieve the effects of reducing infection, preventing and treating influenza and its complications

Inactive Publication Date: 2010-10-20
JIANGXI SHANXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine "Oseltamivir Phosphate (Tamiflu, (3R, 4R, 5S)-4-Acetamide-5-Amino-3(1-Propoxyethyl)-1-Cyclohexene-1 Carboxylic Acid Ethyl Phosphate "Salt)" is a neuraminidase inhibitor, which has a specific inhibitory effect on the entry of influenza virus into cells, but it is not only expensive, but also some patients experience vomiting, nausea, insomnia, headache, abdominal pain, diarrhea, dizziness, fatigue, Side effects such as nasal congestion, sore throat, and coughing

Method used

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  • Acute turpinia leaf general flavone ethanol reflux extract, and preparation method and application thereof
  • Acute turpinia leaf general flavone ethanol reflux extract, and preparation method and application thereof
  • Acute turpinia leaf general flavone ethanol reflux extract, and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation method: Take the coarse powder of the round leaves of Shanxiang, use 50% ethanol as the extractant, soak it for 24 hours, then carry out percolation at a speed of 7ml / kg / min, collect 11 times the percolation liquid of medicinal materials, recover ethanol, and use it as an aqueous solution Absorbed with non-polar macroporous resin, eluted with 15% ethanol to remove impurities, then eluted with 50% ethanol of 6 times the volume of the column, collected the eluate, recovered ethanol, concentrated, dried, and obtained the total The flavonoid ethanol percolation extract has a total flavonoid content of 53.6%, containing 15%, 5%, and 3% of privetin, rhodorin, and hyperoside, respectively.

Embodiment 2

[0031]Preparation method: Take the coarse powder of the round leaves of Shanxiang, use 60% ethanol as the extractant, soak it for 48 hours, and percolate at a speed of 6ml / kg / min, collect 9 times the amount of percolation liquid of medicinal materials, recover ethanol, and use it as an aqueous solution Absorb with non-polar macroporous adsorption resin, elute with 18% ethanol to remove impurities, then elute with 55% ethanol of 5 times the volume of the column, collect the eluate, recycle ethanol, concentrate, and dry to obtain the total The flavonoid ethanol percolation extract has a total flavonoid content of 57.3%, containing 13%, 6%, and 5% of privetin, rhodorin, and hyperoside, respectively.

Embodiment 3

[0033] Preparation method: Take the coarse powder of the round leaves of Shanxiang, use 65% ethanol as the extractant, soak for 40 hours, and percolate at a speed of 5ml / kg / min, collect 8 times the percolation liquid of the medicinal material, recover the ethanol, and use it as an aqueous solution Absorbed with non-polar macroporous resin, eluted with 20% ethanol to remove impurities, then eluted with 60% ethanol of 5 times the volume of the column, collected the eluate, recovered ethanol, concentrated, dried, and obtained the total The flavonoid ethanol percolation extract has a total flavonoid content of 63.7%, containing 10%, 8%, and 7% of privetin, rhodorin, and hyperin, respectively.

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Abstract

The invention relates to an acute turpinia leaf general flavone ethanol reflux extract, which is prepared from acute turpinia through ethanol percolation extraction. A percolation extraction method comprises the following steps: taking acute turpinia leaf coarse powder; adding 30 to 90 percent of ethanol as extracting agents; carrying out soaking for 12 to 72 hours; using the speed of 1 to 8 ml / kg / minute for percolation; collecting percolation liquid accounting for 4 to 15 times of the amount of medical materials; recovering the ethanol; using nonpolar macroporous absorbent resin for absorbing water solution; using the ethanol lower than 20 percent for elution to remove impurities; then, using 25 to 90 percent of ethanol for elution; collecting elution liquid; recovering the ethanol; and carrying out concentration and drying to obtain the acute turpinia leaf general flavone ethanol reflux extract. The general flavone content is higher than 50 percent, and the flavone type major chemical ingredients are one kind or several kinds of materials in nuezhenoside, rhoifolin, hyperin, meletin, cyanidenon, apiolin and glucoside or aglycon thereof. The extract can be used as a neuraminidase inhibitor to be used for preventing and treating flu, and can be made into pharmaceutically acceptable preparations.

Description

technical field [0001] The invention relates to an ethanol percolation extract of total flavonoids from the round leaves of Shanxiang and its preparation method and application. Background technique [0002] At present, influenza virus is becoming more and more serious, and influenza virus is closely related to respiratory diseases and systemic diseases caused by it. my country is one of the countries with high incidence of influenza. Not only has a large population, but also living habits are conducive to the transmission of influenza virus. The average number of episodes ranged from 0.3 to 0.7, and 2 to 4 in key groups. Influenza poses a serious threat to human beings, especially the emerging strains of influenza virus, which not only cause secondary infections of other microorganisms, but also directly lead to organ damage and allergic reactions leading to death. But there is no effective method and treatment means for treating influenza virus and its disease (influenza) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P11/00A61P31/16A61K127/00
Inventor 唐春山王燕平张华敏谢宁吕武清杨小玲刘地发李志勇程帆
Owner JIANGXI SHANXIANG PHARMA
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