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Cefamandole nafate/anhydrous sodium carbonate medicinal composition microsphere injection

A technology of cefamandole sodium and anhydrous sodium carbonate, which is applied in the field of medicine and can solve the problems of low yield of liposome and suspension preparation, unclear clinical effect, and complicated preparation process

Inactive Publication Date: 2012-05-09
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of the above-mentioned patents is relatively complicated, and the preparation yield of liposomes and suspensions is very low, and the clinical effect is not clear

Method used

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  • Cefamandole nafate/anhydrous sodium carbonate medicinal composition microsphere injection
  • Cefamandole nafate/anhydrous sodium carbonate medicinal composition microsphere injection
  • Cefamandole nafate/anhydrous sodium carbonate medicinal composition microsphere injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The preparation of embodiment 1 cefamandole sodium / anhydrous sodium carbonate injection

[0061] Prescription: (100 bottles)

[0062] Cefamandole Sodium 50g

[0063] Anhydrous sodium carbonate 4g

[0064] PGLA 75g

[0065] Propylene glycol 15g

[0066] Tween 80 10g

[0067] Glucose 100g

[0068] Preparation Process:

[0069] (1) 50g cefamandole sodium, 15g propylene glycol and 100g glucose are dissolved in 500ml water for injection to obtain the aqueous phase;

[0070] (2) 75g PGLA and 10g Tween 80 were dissolved in 500ml of chloroform and isopropanol organic solvent with a volume ratio of 1:1 to obtain an oily phase;

[0071] (3) Slowly drop the water phase obtained above into the oil phase under stirring conditions, control the dropping speed to 5ml / min, stir for 10min after dropping, then transfer to a high-speed homogenizer and stir at a high speed for 3 times at a speed of 15000r / min, each 10min, to obtain a uniform white emulsion;

[0072] (4) Put the wh...

Embodiment 2

[0076] The preparation of embodiment 2 cefamandole sodium / anhydrous sodium carbonate injection

[0077] Prescription: (100 bottles)

[0078] Cefamandole Sodium 100g

[0079] Anhydrous sodium carbonate 12g

[0080] PGLA 600g

[0081] Propylene glycol 300g

[0082] Tween 80 200g

[0083] Glucose 800g

[0084] Preparation Process:

[0085] (1) 100g cefamandole sodium, 300g propylene glycol and 800g glucose are dissolved in 2000ml water for injection to obtain the aqueous phase;

[0086] (2) 600g PGLA and 200g Tween 80 are dissolved in 2000ml of chloroform and isopropanol organic solvent with a volume ratio of 1:1 to obtain an oily phase;

[0087] (3) Slowly drop the water phase obtained above into the oil phase under stirring conditions, control the dropping speed to be 10ml / min, stir for 30min after dropping, then transfer to a high-speed homogenizer for high-speed stirring for 5 times at a speed of 15000r / min, each 5min, to obtain a uniform white emulsion;

[0088] (4...

Embodiment 3

[0092] The preparation of embodiment 3 cefamandole sodium / anhydrous sodium carbonate injection

[0093] Prescription: (100 bottles)

[0094] Cefamandole Sodium 200g

[0095] Anhydrous sodium carbonate 20g

[0096] PGLA 800g

[0097]Propylene glycol 400g

[0098] Tween 80 300g

[0099] Glucose 1000g

[0100] Preparation Process:

[0101] (1) 200g cefamandole sodium, 400g propylene glycol and 1000g glucose are dissolved in 4000ml water for injection to obtain the aqueous phase;

[0102] (2) 800g PGLA and 400g Tween 80 were dissolved in 3000ml of chloroform and isopropanol organic solvent with a volume ratio of 1:1 to obtain an oily phase;

[0103] (3) Slowly drop the water phase obtained above into the oil phase under stirring conditions, control the dropping speed to 8ml / min, stir for 20min after dropping, then transfer to a high-speed homogenizer for high-speed stirring 4 times at a speed of 15000r / min, 7min each time, to obtain a uniform white emulsion;

[0104] (4)...

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Abstract

The invention discloses cefamandole nafate / anhydrous sodium carbonate medicinal composition microsphere injection, which is characterized by consisting of cefamandole nafate, anhydrous sodium carbonate, PGLA, Tween-80, propylene glycol and glucose. The invention adopts the preferable scheme that the cefamandole nafate / anhydrous sodium carbonate medicinal composition microsphere injection is characterized by comprising the following components in part by weight: 1 part of cefamandole nafate, 0.08 to 0.12 part of anhydrous sodium carbonate, 1.5 to 6 parts of PGLA, 0.2 to 2 parts of Tween-80, 0.3 to 3 parts of propylene glycol and 2 to 8 parts of glucose. Compared with the prior art, the prepared cefamandole nafate microspheres have stability, a preparation process is simple and suitable forindustrialized production, the entrapment rate is high, and the anhydrous sodium carbonate used as a co-solvent has good resolution and proper slow-release effect.

Description

technical field [0001] The invention relates to a cefamandole sodium / anhydrous sodium carbonate pharmaceutical composition microsphere injection, which belongs to the technical field of medicine. Background technique [0002] Cefamandole sodium is a second-generation cephalosporin antibiotic, which has a strong effect on Gram-negative bacteria and is positive for Clostridium anaerobes, meningococcus, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pneumoniae, influenza bacillus and indole Proteus and other effects are strong, especially the most effective against Haemophilus. Clinically, it is mainly used for various infections caused by sensitive bacteria, such as respiratory tract infection, biliary tract infection, pyelonephritis, urinary tract infection, peritonitis, sepsis and skin soft tissue, bone, joint and other infections. [0003] Chinese patent CN101219117A discloses a preparation method of cefamandole sodium sterile powder injection, which is composed of ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/546A61K47/02A61K47/34A61P31/04
Inventor 廖爱国
Owner HAINAN MEIDA PHARMA
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