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Tartaric acid rogridone dispersing tablet and preparation method thereof

A technology of rosiglitazone and tartaric acid, which is applied in the field of rosiglitazone tartrate dispersible tablets and its preparation, can solve the problems of poor water solubility, low bioavailability and slow absorption of rosiglitazone tartrate, and achieve the expansion of dosage forms, Improve curative effect and fast absorption effect

Inactive Publication Date: 2010-09-08
ZHEJIANG JINGXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Rosiglitazone tartrate has poor water solubility, slow absorption and slow onset of action after oral administration, and low bioavailability. At present, there are no reports on the market of rosiglitazone tartrate dispersible tablets at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] prescription

[0020] Ingredients Dosage

[0021] Rosiglitazone Tartrate 12g

[0022] Lactose 77

[0023] Microcrystalline Cellulose 30g

[0024] 20g pregelatinized starch

[0025] Sodium starch glycolate 7.5g

[0026] Micronized silica gel 3g

[0027] Magnesium stearate 0.5g

[0028]

[0029] A total of 1000 pieces were made

[0030] Preparation method: first pass rosiglitazone tartrate through a 120-mesh sieve, and then pass through a 100-mesh sieve for lactose, microcrystalline cellulose, pregelatinized starch, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate. Fully mix rosiglitazone tartrate, lactose, microcrystalline cellulose, pregelatinized starch, and carboxymethyl starch sodium, add micropowder silica gel and magnesium stearate and mix evenly, calculate the tablet weight, and press the tablet to obtain Roglia tartrate Litazone dispersible tablets.

Embodiment 2

[0032] prescription

[0033] Ingredients Dosage

[0034] Rosiglitazone Tartrate 4.5g

[0035] Lactose 200g

[0036] Microcrystalline Cellulose 120g

[0037] 75g pregelatinized starch

[0038] Crospovidone 30g

[0039] Micronized silica gel 15g

[0040] Magnesium Stearate 5g

[0041]

[0042] A total of 1000 pieces were made

[0043] Preparation method: first pass rosiglitazone tartrate through a 120-mesh sieve, and then pass through a 100-mesh sieve respectively for lactose, microcrystalline cellulose, pregelatinized starch, crospovidone, micropowder silica gel and magnesium stearate. Thoroughly mix rosiglitazone tartrate, lactose, microcrystalline cellulose, pregelatinized starch, and partially cross-linked povidone, dry granulate, add additional cross-linked povidone, micronized silica gel and magnesium stearate and mix Evenly, calculate the weight of the tablet, and press the tablet to obtain rosiglitazone tartrate disp...

Embodiment 3

[0045] prescription

[0046] Ingredients Dosage

[0047] Rosiglitazone Tartrate 8g

[0048] Lactose 240

[0049] Microcrystalline Cellulose 38g

[0050] Crospovidone 12g

[0051] Low-substituted hydroxypropyl cellulose 12g

[0052] Micronized silica gel 6g

[0053] Magnesium Stearate 4g

[0054]

[0055] A total of 1000 pieces were made

[0056]Preparation method: first pass rosiglitazone tartrate through a 120-mesh sieve, and then pass through a 100-mesh sieve respectively for lactose, microcrystalline cellulose, crospovidone, low-substituted hydroxypropyl cellulose, micropowder silica gel and magnesium stearate. Fully mix rosiglitazone tartrate, lactose, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose, dry granulate, add crospovidone, micronized silica gel and magnesium stearate, mix evenly, calculate the tablet weight, Pressing into tablets yields rosiglitazone tartrate dispersible tablets.

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Abstract

The invention discloses a tartaric acid rogridone dispersing tablet for curing II type diabetes mellitus and a preparation method thereof. The water-solubility of the tartaric acid rogridone is inferior, the absorption thereof is slow after taking orally, the bioavailability is low and no tartaric acid rogridone dispersing tablet is marketed at home and abroad. The tartaric acid rogridone dispersing tablet of the invention is prepared by using 0.5 to 15% of tartaric acid rogridone, 10 to 90% of filler, 1 to 10% of disintegrating agent, 0.1 to 30% of adhesive and 0.5 to 6% of lubricating agent. The invention not only widens the dosage form scope of the tartaric acid rogridone but also can rapidly disintegrate the dispersing tablet, quickly absorb and promote the bioavailability and blood concentration so as to promote the curative effect of the drug and conveniently take.

Description

technical field [0001] The invention relates to a new formulation of rosiglitazone tartrate, a medicine for treating type II diabetes, in particular to rosiglitazone tartrate dispersible tablets and a preparation method thereof. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. The 2005 edition of the Chinese Pharmacopoeia has recorded this new drug dosage form of dispersible tablets. , the disintegration time limit is less than 3 minutes, and the disintegrated particles should all pass through the No. 2 sieve. Taking dispersible tablets has the advantages of fast drug release, high bioavailability, and less adverse reactions. Clinical medication can be swallowed like ordinary tablets , and can be put into water to disperse quickly and then taken. Some are taken by chewing or sucking. They are easy to carry and use, and have the advantages of both tablets and liquid preparations. use. [0003] Rosiglitazone tartrate, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4439A61K47/38A61P3/10
Inventor 梁志寿张利锋
Owner ZHEJIANG JINGXIN PHARMA
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