Huperzine A preparation for treating schizophrenia and nervous function damage and preparation method thereof

Abstract

The invention relates to a huperzine A preparation for treating schizophrenia and nervous function damage and a preparation method thereof. The preparation method comprises the following steps: using a solvent dispersing method and a solid-liquid phase dispersing and melting method to properly dissolve huperzine A by solvent, preparing stable huperzine A hydrochloride solution, spraying the huperzine A hydrochloride solution in an auxiliary material by dispersion, or preparing solid dispersoid mixture with uniform phase dispersion, crushing, mixing and stirring uniformly, directly adding a lubricating agent for tabletting, also being capable of adding a binding agent, granulating, drying, adding the lubricating agent, and tabletting. The phase-dispersing mixture of huperzine A also can be added with the lubricating agent with proper amount for mixing, and then filled into a capsule. The preparation is used for treating the symptoms of all the periods of schizophrenia, and has the advantages of having the effects of protecting oxidative stress toxicity of nerve cells generated by resisting Beta amyloid peptide and inducing cell apoptosis, promoting the growth of nerve growth factor, being effective for treating inflammation in cerebral hemorrhage and inflammation of cerebral ischemic injury, having long action time of drugs, being convenient to application of oral administration / containing administration and the like. The invention has high content of huperzine A preparation, stable preparation quality and good bioavailability and can improve the medication compliance of patients with schizophrenia and senile dementia.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a huperzine A preparation for treating schizophrenia and nerve function damage and a preparation method thereof. Background technique [0002] The chemical name of huperzine A is (5R, 9R, 11E) 5-amino-11-ethylene-5, 6, 9, 10-tetrahydro-7methyl-5, 9-methylene-5, 9-Cyclooctatraeno(b)pyridin-2(1H)one. Huperzine A is a pure natural alkaloid extracted from Chinese herbal medicine Huperzia serrata (Thunb.) Trev (also known as Huperzia serrata, snake foot grass) and other plants. Taquancao is used in bruises, congestion, swelling, schizophrenia and other diseases, and the huperzine A contained in it is a highly efficient, reversible and highly selective central acetylcholinesterase inhibitor, which is highly effective and low in toxicity. True acetylcholinesterase has a selective inhibitory effect, easily passes through the blood-brain barrier, has a long acting time, and has the e...

AI Technical Summary

Problems solved by technology

The existing huperzine A injection requires intramuscular injection, which is inconvenient for patients to use and causes unnecessary pain. During long-term trials, the patient's compliance is poor, and the high-efficiency, high-bioavailability oral preparation for the treatment of schizophrenia not yet available