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Functionalized polyester and preparation method thereof

A functionalized polyester technology, applied in the field of functionalized polyester and its preparation, can solve the problems of single response to external environmental stimuli and difficult copolymerization, and achieve the effects of good biocompatibility and simple operation.

Active Publication Date: 2012-07-11
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical Communication p4411-4413 (2009) reported a kind of catalyst catalyzed 2-((2-(2-methoxyethoxy) ethoxy) methyl) oxirane and butane with aluminum triisopropoxide Diacid anhydride polymerization, functionalized polyester is obtained by bulk polymerization at 120 °C, the functionalized polyester is biodegradable and temperature sensitive, but it is difficult to achieve copolymerization with other polymers, and the stimulus response to the external environment is too simple

Method used

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  • Functionalized polyester and preparation method thereof
  • Functionalized polyester and preparation method thereof
  • Functionalized polyester and preparation method thereof

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preparation example Construction

[0046] The present invention also provides a preparation method of functionalized polyester, comprising: under anhydrous conditions, a small molecule alcohol or a polymer initiator with a melting point lower than 120°C, stannous isooctanoate, and a molar ratio of 1:1 The functionalized epoxy compound and the functionalized anhydride are mixed to obtain a mixture;

[0047] heating and stirring the mixture at 100°C to 150°C for 34h to 38h, causing the mixture to undergo a polymerization reaction to obtain a polymer;

[0048] After diluting and filtering the polymer, the filtrate is taken, and then the filtrate is subjected to sedimentation, washing and drying operations to finally obtain the functionalized polyester.

[0049] According to the present invention, first under anhydrous conditions, the functionalized epoxy compound and the functionalized acid anhydride that the small molecular alcohol or the melting point is lower than 120 ℃ polymer initiator, stannous isooctanoate,...

Embodiment 1

[0053] Example 1: Preparation of poly(2-((2-methoxyethoxy)methyl)oxirane-co-glutaric anhydride) of different chain lengths

[0054] Under anhydrous conditions, weigh 7 parts of 2-((2-methoxyethoxy) methyl) oxirane and 4.32 g of glutaric anhydride with a mass of 5.0 g, and put them into 7 dry In the reaction flask, add 0.258g, 0.052g, 0.026g, 0.013g, 0.009g, 0.006g, 0.005g aluminum triisopropoxide respectively, and react at 120°C for 36 hours under bulk conditions and stirring with a stir bar. After the reaction, use three Dilute the reaction system with methyl chloride, filter off the insoluble matter, settle in a mixed solvent of ether, n-hexane and ethyl acetate, wherein the volume ratio of ether, n-hexane and ethyl acetate is 1:8:1, wash the product with n-hexane , and dried under vacuum at 25°C for 24h to obtain poly(2-((2-methoxyethoxy)methyl)oxirane-co-glutaric anhydride) with different chain lengths. The resulting functionalized polyester is shown in Table 1.

[0055]...

Embodiment 2

[0058] Embodiment 2: Preparation of poly(2-((2-(2-methoxyethoxy)ethoxy)methyl)oxirane-co-glutaric anhydride):

[0059] Under anhydrous conditions, weigh 6.67g of 2-((2-(2-methoxyethoxy)ethoxy)methyl)oxirane and 4.32g of glutaric anhydride, put Add 0.026g of aluminum triisopropoxide to the dry reaction bottle, and react for 36h under the bulk condition of 120°C and stirring with a stirring bar. Settled in a mixed solvent of ethyl acetate, wherein the volume ratio of ether, n-hexane and ethyl acetate was 1:8:1, washed the product with n-hexane, dried in vacuum at 25°C for 24h, and obtained poly(2-((2- (2-Methoxyethoxy)ethoxy)methyl)oxirane-co-glutaric anhydride). Depend on 1 The degree of polymerization of the product determined by H NMR was 100, and the number average molecular weight was 29060. Reaction yield: 86.1%.

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Abstract

The invention provides a functionalized polyester, which is prepared by polymerizing functionalized epoxy compound and functionalized anhydride. Because the functional groups on the functionalized epoxy compound and the functionalized anhydride have sensitivity on changes of pH value, temperature and ionic strength, so the polyester prepared from the epoxy compound and the anhydride with the functional groups has multi-responsiveness, a structural unit contained in the polyester has good biocompatibility, and the polyester is biodegradable due to the existence of ester bonds. The functionalized polyester not only has multi-responsiveness, but also has biocompatibility and biodegradability. The invention also provides a preparation method of the functionalized polyester, the method is operated simply, and the reaction is rapid so as to control preparation process of the polyester well.

Description

technical field [0001] The invention relates to the field of polymer synthesis, in particular to a functionalized polyester and a preparation method thereof. Background technique [0002] Aliphatic polyesters represented by polyε-caprolactone, polylactide, polyglycolide, polycarbonate, etc., have attracted extensive attention in the fields of biomedicine and pharmacy due to their good biocompatibility and mechanical properties . These polyesters have good application prospects in the fields of biodegradable sutures, tissue engineering scaffolds, and drug delivery and controlled release. However, their applications are limited due to their hydrophobicity, semi-crystallinity, and rejection reactions caused by inappropriate interactions with cells in vivo, such as inflammation, tissue necrosis, and thrombosis. Moreover, since these polyesters lack functional groups, various functionalizations and environmental responsiveness cannot be achieved. [0003] Polymers that can rea...

Claims

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Application Information

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IPC IPC(8): C08G63/66C08G63/685C08G63/78
Inventor 庄秀丽丁建勋汤朝晖陈学思
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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