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Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine

A technology of pseudoephedrine and slow-release preparations, which is applied in the field of medicine to achieve the effects of high safety, less frequency of medication, and reduced frequency of taking

Active Publication Date: 2013-01-23
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no specific treatment at all, it is not necessary for the virus to be firm, and only symptomatic treatment can be used to relieve many symptoms of the common cold

Method used

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  • Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine
  • Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine
  • Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021]

[0022] Preparation method 1:

[0023] (1) Preparation of granules Hypromellose and microcrystalline cellulose were sieved separately and mixed evenly. Then add pseudoephedrine hydrochloride, chlorpheniramine maleate, and benoxylate in sequence, mix well, use 5% povidone K30 aqueous solution as a binder to make a soft material, make wet granules with a 20-mesh sieve, dry at 50°C, and dry for 20 Mesh sieve whole grain, set aside.

[0024] (2) Preparation of coating solution Add Opadry to pure water, and add pure water to 100ml, stir for 1 hour, set aside.

[0025] (3) Coating the granules of (1) to obtain coated granules.

[0026] (4) Add an appropriate amount of magnesium stearate to the granules obtained in (3), mix well, and press into tablets to obtain tablets.

[0027] (5) Add an appropriate amount of magnesium stearate to the granules obtained in (1), mix well, press into tablets, take (2) coating solution, wrap it on the outside of t...

Embodiment 2

[0039] prescription:

[0040]

[0041] Preparation method 1:

[0042](1) Preparation of granules: sieve hypromellose and microcrystalline cellulose separately, and mix well by equal increment method, then add pseudoephedrine hydrochloride, beinolate and chlorpheniramine maleate in the prescribed amount 2g, make it mix evenly, use 10% copovidone K30 aqueous solution as binder to make soft material, make wet granules with 20 mesh sieve, dry at 60°C, granulate with 20 mesh sieve, and set aside.

[0043] (2) Preparation of coating solution Add 2 g of chlorpheniramine maleate and Opadry to pure water, and add pure water to 100 ml, stir for 0.5 hours, and set aside.

[0044] (3) Coating the granules of (1) to obtain coated granules.

[0045] (4) Add an appropriate amount of stearic acid to the granules obtained in (3), mix well, and press into tablets to obtain Tablet I.

[0046] (5) Add an appropriate amount of stearic acid to the granules obtained in (1), mix well, press int...

Embodiment 3

[0060] prescription:

[0061] pseudoephedrine sulfate

120g

Chlorpheniramine maleate

4.0 g

Benoate

400g

blank core

120g

Hypromellose E5

10g

Surelease Solids

30g

Water Soluble Coating Powder

10g

Titanium dioxide

1g

stearic acid

5g

Povidone K 30

Appropriate amount

water

Appropriate amount

Absolute ethanol

Appropriate amount

[0062] Coating prescription:

[0063] Opadry

30 g

water

Add to 1000ml

[0064] Made into 1000 grains (tablets)

[0065] Preparation:

[0066] (1) Pseudoephedrine Sulfate Sustained Release Pellets

[0067] Ⅰ. Prepare 10% HPMC E5 aqueous solution for later use;

[0068] Ⅱ. Take the Surelease solid, add water, shake well and set aside;

[0069] Ⅲ. Prepare a water-soluble coating solution containing 10% of water-soluble coating powder and 1% of titanium dioxide;

[0070] Ⅳ, prepare 40...

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PUM

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Abstract

The invention provides a compound preparation which can comprehensively overcome the symptom relative to cold and can slowly release all the active ingredients. The slow-release preparation of the invention not only can overcome the symptom relative to cold but also can perform the synergistic function of compound medicine. The three active ingredients of the slow-release preparation of the invention can be released and absorbed synchronously so as to acquire expected releasing action in human body. The preparation of the invention can be taken for two times per day, namely, can be taken for one time in morning and evening instead of taking four times per day in the past. The preparation of the invention is characterized by less taking times, slow release in body, stable blood concentration, small fluctuation, high bioavailability and high safety.

Description

technical field [0001] The invention relates to a sustained-release preparation with benolate, pseudoephedrine or a physiologically acceptable salt thereof and chlorpheniramine or a physiologically acceptable salt thereof as active components, belonging to the field of medicine. Background technique [0002] A cold is an infection of the upper respiratory tract mucosa caused by many different types of viruses. The main symptoms are nasal congestion, sneezing, mild sore throat, and fever. Systemic symptoms include general discomfort, headache, and myalgia. Because there is no specific treatment at all, it is not necessary to make the virus firm, and only symptomatic treatment can be used to promote the relief of many symptoms of the cold. Since there is still no one drug to alleviate the coexisting symptoms, various compound preparations have been listed one after another. These compound preparations are composed of drugs with different curative effects to relieve different ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/621A61K31/4402A61K31/137A61P31/16A61P11/00
Inventor 林鹏李育巧郑顺利
Owner 北京科信聚润医药科技有限公司
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