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Quick-release tablet and preparation method thereof

An immediate-release tablet and immediate-release tablet technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, oil/fat/wax non-active ingredients, etc., can solve the problem of no immediate-release tablets and no long-term dispersion In order to achieve the effects of increasing drug stability, a wide range of drug selection, and good therapeutic effects

Inactive Publication Date: 2010-06-23
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Among the patents and literature reports seen so far, there is no long-acting dispersible tablet report using slow and controlled release preparation technology in oral immediate release tablets, especially in dispersible tablet preparations; and no oral slow and controlled release preparations Immediate-release tablet reports

Method used

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  • Quick-release tablet and preparation method thereof
  • Quick-release tablet and preparation method thereof

Examples

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preparation example Construction

[0016] The preparation method of the immediate-release tablet of the present invention is to divide the original drug that is called the immediate-release tablet into two parts, and one part adopts pharmaceutically acceptable microencapsulation, coating method, hydrophobic solid dispersion or matrix type Granules are prepared into sustained-release drug components, and then another part of the original drug is prepared into immediate-release drug components by a pharmaceutically acceptable micronization method, micro-powder crystallization method, or hydrophilic solid dispersion method, and then mixed with sustained-release drug components. The ingredients are mixed separately, and finally prepared into immediate-release tablets by ordinary tablet technology.

[0017] The above disintegrants and / or fillers are selected from pharmaceutically acceptable disintegrators and / or fillers, including starch, pregelatinized starch, lactose, agar, croscarmellose sodium, carboxymethyl One...

Embodiment 1

[0025] Embodiment 1: Quinapril Hydrochloride Immediate Release Tablets

[0026] prescription:

[0027] Quinapril hydrochloride 4g (1g is raw material powder, 3g is wrapped into microcapsules)

[0028] Lactose 2g

[0029] Microcrystalline Cellulose 3g

[0030] Cross-linked polyvinylpyrrolidone 4g (add 2g inside; add 2g outside)

[0031] Sodium carboxymethyl starch 1g

[0032] Aspartame 0.6g

[0033] Magnesium stearate 0.15g

[0034] Micronized silica gel 0.1g

[0035] 10% polyvinylpyrrolidone K30 alcohol 3ml

[0036] A total of 100 pieces were made

[0037] Prepared by wet granulation and tabletting technology: quinapril hydrochloride micropowder, lactose, microcrystalline cellulose, PVPP (internal added part) are fully mixed and passed through a 60-mesh sieve, and 10% polyvinylpyrrolidone K30 alcohol solution is added to prepare Moderately wet and dry soft material, granulate with 20 mesh sieve, dry at 50°C for 3 hours, granulate with 20 mesh sieve, add quinapril micr...

Embodiment 2

[0040] Embodiment 2: Valacyclovir hydrochloride immediate release tablet

[0041] Each 100 tablets contains the following substances

[0042] Valacyclovir hydrochloride 15g (3g raw material micropowder, 12g encapsulated into microcapsules)

[0043] Lactose 2g

[0044] Microcrystalline Cellulose 3g

[0045] Cross-linked polyvinylpyrrolidone 4g (add 2g inside; add 2g outside)

[0046] Sodium carboxymethyl starch 1g

[0047] Aspartame 0.5g

[0048] Magnesium stearate 0.1g

[0049] Micronized silica gel 0.1g

[0050] Tween 800.3g

[0051] 5% polyvinylpyrrolidone S630 aqueous solution 10ml

[0052] A total of 100 pieces were made

[0053] Preparation process: valacyclovir hydrochloride micropowder, lactose, microcrystalline cellulose, and cross-linked polyvinylpyrrolidone (internal added part) are fully mixed and passed through a 60-mesh sieve, and an aqueous solution containing Tween 80 and 5% polyvinylpyrrolidone S630 is added, Make a soft material with moderate dryness a...

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Abstract

The invention relates to a quick-release long-acting novel tablet and a preparation method thereof, belonging to the new technical field of oral drug preparation in pharmacy. Sustained-release acting drug components are added in the dispersible tablet prescription, thereby combining the quick-release effect of the tablet preparation and the long-acting effect of the sustained-release preparation and achieving the quick-release long-acting effect. The quick-release long-acting novel tablet is more applicable to the patient needing both the immediate effect and the long-acting effect of the oral drug preparation.

Description

【Technical field】 [0001] The invention relates to an immediate-release tablet and a preparation method thereof. 【Background technique】 [0002] Immediate-release preparations refer to a class of preparations in which the drug is released quickly from the preparation, thereby making it absorb quickly and exert its curative effect quickly. Currently, the solid immediate-release tablets involved in oral administration are mainly dispersible tablets, sublingual tablets, buccal tablets, slices, freeze-dried slices, etc. Dispersible tablets refer to tablets that can disintegrate rapidly and evenly disperse in water. They can be dispersed with water and then taken orally, or the dispersible tablets can be sucked or swallowed in the mouth. Compared with ordinary tablets, the disintegration of dispersible tablets is not affected by the physiological environment, and has the characteristics of rapid dispersion and high bioavailability; at the same time, due to its uniform dispersion,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/32A61K47/34A61K47/36A61K47/38A61K47/44
Inventor 赵应征鲁翠涛李校堃傅红兴周志彩高慧升田吉来唐琴琴靳卓徐艳艳
Owner WENZHOU MEDICAL UNIV
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