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Application of corosolic acid in preparation of antidepressant drug

A corosolic acid and antidepressant technology, which is applied in the application field of corosolic acid in the preparation of antidepressant drugs or health care drugs, can solve the problems of inducing suicide, easily causing anxiety, blurred vision and the like, and achieves significant activity, Antidepressant activity, no toxic effects

Inactive Publication Date: 2010-06-16
陈军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently used to treat depression, such as tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors, all have certain side effects: such as inducing suicide, reducing libido, easily causing anxiety, blurred vision, etc. ( Liu Wen, Chinese Pharmacy, 2007, Volume 18, Issue 1, 66-68)

Method used

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  • Application of corosolic acid in preparation of antidepressant drug
  • Application of corosolic acid in preparation of antidepressant drug
  • Application of corosolic acid in preparation of antidepressant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1. Mouse forced swimming experiment:

[0016] (1) Experimental animals: male Kunming mice, weighing 18-22 g, housed in groups of 10 per cage, free to eat and drink, room temperature (23±2)°C, natural light.

[0017] (2) Experimental method: the mice were randomly divided into 5 groups, 10 in each group. ①Blank control group; ②Positive control group, given the antidepressant drug fluoxetine at a dose of 10 mg / kg, which is widely used clinically and has good antidepressant effect; ③Experimental group, given corosolic acid, Divided into low, medium and high dose groups, the doses were 10mg / kg, 40mg / kg, 70mg / kg respectively.

[0018] Corosolic acid was added with 0.4% emulsifier Tween-80, prepared into emulsion with normal saline, and administered into the stomach; An equal volume of normal saline containing fluoxetine (containing an equal amount of Tween-80) in the stomach.

[0019] Mice in each group were administered orally once a day in the morning for 7 c...

Embodiment 2

[0025] Example 2. Mouse tail suspension experiment

[0026] (1) Experimental animals: male Kunming mice, weighing 18-22 g, housed in groups of 10 per cage, free to eat and drink, room temperature (23±2)°C, natural light.

[0027] (2) Experimental method: the mice were randomly divided into 5 groups, 10 in each group. ①Blank control group; ②Positive control group, given the antidepressant drug doxepin at a dose of 50 mg / kg, which is widely used clinically and has good antidepressant effect; ③Experimental group, given corosolic acid, Divided into low, medium and high dose groups, the doses were 10mg / kg, 40mg / kg, 70mg / kg respectively.

[0028] Corosolic acid was added with 0.4% emulsifier Tween-80, prepared into emulsion with normal saline, and administered into the stomach; An equal volume of normal saline containing doxepin (containing an equal amount of Tween-80) in the stomach.

[0029] Mice in each group were administered orally once a day in the morning for 7 consecutive...

Embodiment 3

[0036] 10kg of Potentilla spinach was crushed and extracted 3 times under reflux with 90% ethanol, each time for 8 hours, and the ethanol was recovered under reduced pressure to obtain 280g of extract, which was suspended with a small amount of water, and then respectively washed with petroleum ether, ethyl acetate, Extracted with n-butanol and separated with ethyl acetate by conventional silica gel column chromatography and gel column chromatography to obtain corosolic acid: white powder, mp 252~254°C; ESI-MS (m / z): 471[ M-H] - ; 1 H NMR (300MHz, pyridine-d 5 )δ: 0.94(3H, s), 0.96(3H, s), 0.97(3H, s), 1.02(3H, s), 1.05(3H, s), 1.18(3H, s), 1.25(3H, s ), 2.61 (1H, d, J = 11.5Hz), 3.36 (1H, d, J = 9.5Hz), 4.08 (1H, ddd, J = 4.3, 9.5, 11.1Hz), 5.47 (1H, t, J = 3.5Hz); 13 C NMR (300MHz, pyridine-d 5 )δ: 17.1, 17.5(2C), 17.8, 18.9, 21.3, 23.8, 23.9, 25.2, 28.9, 29.4, 31.3, 33.7, 37.5, 38.3, 39.4, 39.5, 39.8, 40.1, 42.6, 48.0(2C), 48.1 , 53.6, 60.3, 68.6, 84.1, 125.5, 139.6, ...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to new application of corosolic acid. The corosolic acid is scientifically named as 2alpha-hydroxyursolic acid, and is a natural product existing in multiple medicinal and edible plants of banaba leaf, potentilla chinensis, loguat leaf, shine skin papaya, pomegranate extract and the like. The corosolic acid has remarkable antidepression activity without side and toxic effects, and can be used for preparing the antidepressant drugs.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to the application of corosolic acid in the preparation of antidepressant medicines or health care medicines. Background technique [0002] In today's society, the competition is intensified, the gap between the rich and the poor is large, and people's expectations are too high, which makes the incidence of depression show a trend of increasing year by year. According to incomplete statistics, at present, patients with depression account for 3% to 5% of the world's population. It is estimated that by 2020, depression will become the second largest disease after heart disease. [0003] Depression is a common mental illness characterized by marked and persistent low mood, behavioral stiffness, and pessimistic world-weariness. The drugs currently used to treat depression, such as tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors, all have certa...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P25/24
Inventor 陈军
Owner 陈军
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