Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Extractive of Taxus chinensis var.mairei leaves and preparation method

A technology of Taxus chinensis and extracts, which can be used in drug combinations, medical raw materials derived from gymnosperm subphylum, cardiovascular system diseases, etc., can solve the problems of non-selective extraction of target compounds, large industrial pollution, and long extraction time. , to achieve the effect of benefiting angina pectoris, short extraction time and high extraction rate

Inactive Publication Date: 2010-06-02
宁波泰康红豆杉生物工程有限公司
View PDF0 Cites 28 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional extraction methods have defects such as long extraction time, complicated process, low efficiency, large industrial pollution and no selectivity for the extraction of target compounds.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Extractive of Taxus chinensis var.mairei leaves and preparation method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0023] Taking SD rats as the experimental object, giving the extract 4.4g (crude drug) / kg (mouse) in the above-mentioned embodiment every day is the administration group, dissolves with physiological water and administers it by gavage, after 7 days, it is compared with the matched group (normal saline). Equal-volume gavage for 7 days) At the same time, blood was taken from the vein, with adenosine diphosphate sodium salt (ADP) as the inducer, the platelet aggregation percentage of each group was measured according to the Born turbidimetry, and the heart blood was taken at the same time, and formed on the thrombosis instrument. Thrombus, the results showed that compared with the control group, the 1min platelet aggregation rate was significantly reduced in the treatment group, the difference was statistically significant (P<0.05), and the thrombus length was also significantly shortened (P<0.05). It shows that the extract can effectively inhibit ADP-induced platelet aggregation ...

experiment example 2

[0025] Take rats as the experimental object, give the extract 4.4g (crude drug) / kg (mouse) in the above-mentioned embodiment every day as the administration group, dissolve it with physiological water and administer it by gavage, after 8 days, compare with the control group (normal saline, etc.) Volumetric gavage for 8 days) simultaneously injected epinephrine and calcium chloride to induce arrhythmia, and the results showed that compared with the control group, the administration group had significantly antagonizing arrhythmia effect (P<0.05). In the experiment on the effect on heart function, it was found that the intravenous injection of the extract can significantly antagonize the effect of norepinephrine on raising blood pressure, and has a certain rebound effect on the lowering of blood pressure caused by histamine, among which LVEDP, BP indicators were significantly reduced, but HR had no significant change. This effect is to reduce arterial blood pressure and left ventr...

experiment example 3

[0027]Taking the dog as the experimental object, giving the extract 4.4g (crude drug) / kg (dog) in the above-mentioned embodiment and dissolving the gavage administration with physiological water is the administration group, and the equal-volume normal saline gavage is the control group, after gavage The left circumflex coronary artery was isolated from the treatment group and the control group at the same time, and the coronary blood flow was measured by the MFV-110 electromagnetic flowmeter probe to calculate the coronary resistance, and the myocardial oxygen consumption was measured by the Unistat oximeter. The results showed that the myocardial oxygen consumption and oxygen consumption index of the administration group decreased significantly at 5 minutes, and the myocardial oxygen consumption decreased most significantly at 45 minutes after administration, which was significantly different from that before administration and the control group (P<0.01 and (P <0.001), indicat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an extractive of Taxus chinensis var.mairei leaves and a preparation method. The extractive is a straw yellow powder. The powder contains sciadopitysin the weight content of which is 65-70 percent; the sciadopitysin contains the following five components: 3-O-rutin-quercetol, 3-O-rutin-campherol, 3-O-rutin-myricetin, 7-O-glucose-campherol and 7-O-glucose-quercetol, and the total weight content of the five components in the sciadopitysin is 40-60 percent. The extractive is prepared by the preparation method comprising the steps of baking, crushing and screening, immersing into an alcohol dissolvant, ultrasonically extracting while stirring, decompressing and concentrating an extracting solution to remove alcohol, extracting with chloroform and degreasing, water phase concentrating and drying by taking fresh Taxus chinensis var.mairei leaves as raw materials. The extractive of Taxus chinensis var.mairei leaves has the functions of improving heat microcirculation, resisting arrhythmia, lowering myocardial oxygen consumption and the like and having the therapeutic and health-care function on diseases of cardiovascular system; and the preparation method has low energy consumption, short extracting time, few impurities and higher extraction efficiency.

Description

technical field [0001] The invention relates to plant effective components and extraction technology, in particular to an extract of southern yew leaves and a preparation method. Background technique [0002] Paclitaxel isolated from the genus Taxus is the first effective natural anticancer drug. Paclitaxel has been widely used in the clinical treatment of various tumors and has attracted more and more attention from all over the world. In addition to paclitaxel, the medicinal ingredients of yew also contain a class of substances with important pharmacological activities: taxoflavones. Flavonoids (Flavonoids), also known as bioflavonoids (bioflavonoids), are a class of low-molecular plant secondary metabolites, widely distributed in vegetables, fruits and medicinal plants. These compounds have a common core C 6 -C 3 -C 6 At present, hundreds of flavonoids have been isolated from plant materials, and new compounds are constantly being discovered. According to the differe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/13A61P9/00A61P9/06A61P9/10A61K127/00
Inventor 王强阮晓张莺莺
Owner 宁波泰康红豆杉生物工程有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com