Dripping pill for treating coronary heart diseases and preparation method thereof

Abstract

The invention relates to a dripping pill for treating coronary heart diseases, which comprises a medicinal active component, a substrate auxiliary material, a plastic component, propylene glycol and water, wherein the medicinal active component is prepared from radix salviae miltiorrhizae, radix notoginseng and borneol; the substrate auxiliary material is erythrol; the plastic component is selected from one or more of polyethylene glycol, xylitol, lactitol, manna sugar, glycerol, soluble starch, gelatin, methyl cellulose, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, acacia, alginic acid, dextrin, schardinger dextrin, citric acid ester, acetoglyceride, dibutyl sebacate, refined coconut oil and castor oil; and relative to the total weight of the dripping pill, the dripping pill comprises the following components by weight percent: 1-40% of medicinal active component, 0-10% of plastic component, 1-10% of propylene glycol, 0-10% of water and the balance substrate auxiliary material. The dripping pill has safety, no toxicity, low moisture-absorption property and high dissolution and dispersion speed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a dropping pill and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary heart disease is the abbreviation of coronary heart disease. It is a disease with high morbidity and mortality and seriously endangers the health of human beings, so it is called "the first killer of human beings". Angina pectoris is a clinical syndrome caused by coronary artery blood supply insufficiency, myocardial acute, transient ischemia and hypoxia. It often occurs when you are tired, full of food, cold and emotional, and there is a sudden pain behind the sternum with an unclear range. Squeezing ...

AI Technical Summary

Problems solved by technology

[0010] However, the current drop pill preparations generally face the following problems: the drop pill auxiliary materials are not purely natural

These synthetic auxiliary materials are all mixtures with a certain range of molecular weight distribution, resulting in difficult control of the quality of the drop pills, and there are differences between batches; from the perspective of safety, the traditional drop pill base auxiliary materials of polyethylene glycol have certain gastrointestinal tract irritation and hemolysis, affecting the compliance of patients with medication; the prepared drop pills have poor stability, are easy to absorb moisture, and are easy to stick when heated, etc.

And the finding of new natural matrix auxiliary materials and the determination of its preparation process are very difficult things, because the preparation conditions required for common possible natural matrix auxiliary material substitutes are very harsh at present, and the temperature of auxiliary materials and the dripping conditions of dropping pills are all different. It is the key to affect the preparation of dripping pills

If the melting temperature of the auxiliary material is too high, the viscosity will be low and the plasticity will be poor. When the melting temperature of the auxiliary material is too low, the plasticity will be strong, but the dripping pills have disadvantages such as easy sticking and deformation. The excipients of the pill matrix is ​​a very difficult job

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