Paracetamol temperature sensitive gel and preparation method and application thereof

Abstract

The invention relates to a paracetamol temperature sensitive gel and a preparation method thereof. The preparation is prepared by paracetamol, poloxamer solution and preservative and the like. The preparation of the thermosensitive gel is sensitive to the temperature, is flowable liquid at normal temperature, has reversible phase change closing to 33-37 DEG C of body temperature to form gel to directly act on administration position, thus not only being capable of being used for local administration, but also giving play to the function of treating the whole body through mucous membrane absorption; in addition, the preparation can conveniently and effectively be applied to body cavity mucous membranes and skin surfaces such as oral cavity, nasal cavity, rectum and vagina and the like, thus having antipyretic and analgesic functions. As the use dosage can be conveniently adjusted according to the needs of the patients, the preparation is suitable for bringing down a fever of infants rapidly, thus avoiding the problems of inconvenient administration by using the common formulations, such as paracetamol tabella and paracetamol turunda and difficult adjusting of dosage according to the needs of the patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a paracetamol temperature-sensitive gel and a preparation method and application of the gel. Background technique [0002] Paracetamol, also known as acetaminophen, belongs to aniline derivatives. By inhibiting the synthesis of prostaglandins in the central nervous system, it produces antipyretic and analgesic effects, and has no obvious effect on COX in peripheral tissues. Its antipyretic and analgesic effects are similar to aspirin, but have no obvious anti-inflammatory effects. Oral administration is easy to absorb, and the blood concentration reaches the peak within 0.5-1 hour. In the body, 95% is combined with glucuronic acid or sulfuric acid to be inactivated, and 5% is converted into metabolites toxic to the liver by the liver and excreted from the urine. This drug is an over-the-counter drug, mainly used for antipyretic and analgesic. Short-term use has mild adve...

AI Technical Summary

Problems solved by technology

Nevertheless, its use is still subject to certain restrictions, such as tablets are not conducive to swallowing by the elderly, oral preparations have certain irritation to the gastrointestinal tract, and injections are inconvenient to use; in addition, pediatric medication also has great particularity, and its compliance Very poor, if only oral preparations are used, a little carelessness will easily lead to children being choked or the medicine being spit out, which not only fails to achieve the purpose of treatment, but sometimes even backfires, leading to other adverse consequences

Therefore, rectal administration has attracted attention, but the only paracetamol suppository for children currently on the market is semi-solid, which will produce an obvious foreign body sensation when used, softens after use and has no bioadhesive effect, and the suppository may go up to the top of the rectum or from Rectal outflow causes leakage, so the first-pass effect reduces the efficacy of the drug; in addition, the dosage of ordinary suppositories is fixed, and the dosage cannot be adjusted in children, so the use is limited

Although the enema preparation overcomes these problems to a certain extent, there is the problem of easy leakage

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