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Soft-measuring method for density in concentration process of salvia miltiorrhiza injection production

A technology of Danshen injection and concentration process, which is applied in neural learning methods, program control, biological neural network models, etc., to achieve good application prospects, strong model interpretation ability, and simple calculation effects

Inactive Publication Date: 2011-09-28
ZHEJIANG UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no patent achievement in the field of soft measurement for the injection concentration process in China

Method used

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  • Soft-measuring method for density in concentration process of salvia miltiorrhiza injection production
  • Soft-measuring method for density in concentration process of salvia miltiorrhiza injection production
  • Soft-measuring method for density in concentration process of salvia miltiorrhiza injection production

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Embodiment 1

[0031] Embodiment 1: the linear soft sensing method (PLS) of the concentration process density of Danshen injection

[0032] The principle of the inventive method sees figure 1 .

[0033] The historical data set {X, D} comes from the enrichment section of Danshen injection produced by a pharmaceutical company. Three batches of data are selected, and the number of sampling points in each batch is 60. The selection of samples is evenly distributed throughout the enrichment process. Among them, X is the process variable data that is easily obtained by the sensor in the production line and is relatively accurate, including 9 process variables: heater (X 1 ), Inlet flow rate (X 2 ), cumulative liquid intake (X 3 ), evaporator vacuum (X 4 ), gas phase temperature (X 5 ), liquidus temperature (X 6 ), liquid level (X 7 ), buffer tank pressure (X 8 ) and cooling water flow rate (X 9 ); D is the measured density value of the concentrate, collected using an online density meter....

Embodiment 2

[0048] Embodiment 2: The non-linear soft sensor method (ANN) of the concentration process density of salvia miltiorrhiza injection

[0049] The historical data set {X, D} comes from the enrichment section of Danshen injection produced by a pharmaceutical company. Five batches of data are selected, and the number of sampling points in each batch is 80. The selection of samples is evenly distributed throughout the enrichment process. Among them, X is the process variable data that is easily obtained by the sensor in the production line and is relatively accurate, including 9 process variables: heater (X 1 ), Inlet flow rate (X 2 ), cumulative liquid intake (X 3 ), evaporator vacuum (X 4 ), gas phase temperature (X 5 ), liquidus temperature (X 6 ), liquid level (X 7 ), buffer tank pressure (X 8 ) and cooling water flow rate (X 9 ); D is the measured density value of the concentrate, collected using an online density meter. In order to reduce the systematic error, the data...

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Abstract

The invention provides a soft-measuring method for density in concentrating process of salvia miltiorrhiza injection production, comprising the following steps: gathering the historical data of each sensor and densimeter in the concentration process of salvia miltiorrhiza, wherein the history data relate to concentrated solution density value and sensor data gathered on line in production process; selecting easily obtained procedure variables including gas phase temperature, liquid phase temperature, pressure and concentrated solution liquid level that have higher degree of correlation with density from each sensor data, and screening representative dataset; using a multivariate analysis method for building a soft-measuring model of density; and gathering the procedure variables on line, and using the soft-measuring model of density to carry out real-time estimation to control the concentration process. Aiming at the problem that the density in the concentration process of salvia miltiorrhiza injection production is difficultly monitored in real time, the invention provides a fast density soft-measuring method with high precision, which makes full use of the history data obtained by each sensor from the production process, and is beneficial to improvement of quality control on salvia miltiorrhiza injection production.

Description

technical field [0001] The invention belongs to a method for measuring the production process of traditional Chinese medicine, and relates to a soft measurement method for the production process of traditional Chinese medicine, especially a soft measurement method for the density of concentrated liquid in the concentration process of Danshen injection, including multiple linear regression (MLR), principal component regression ( PCR), partial least squares (PLS) and artificial neural network (ANN) soft sensor models of multiple multivariate analysis methods. Background technique [0002] The pharmaceutical process of traditional Chinese medicine includes basic steps such as extraction, concentration, and alcohol precipitation. The concentration process is an important link in the production of traditional Chinese medicine. It evaporates and concentrates the medicinal liquid obtained in the extraction process to make the density of the medicinal liquid meet the production requ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G05B19/048G06N3/02G06N3/08
Inventor 瞿海斌方利民程翼宇
Owner ZHEJIANG UNIV
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