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Industrial technology for quickly extracting high-purity chlorogenic acid from sweet potato leaf

A technology of chlorogenic acid and sweet potato leaves, applied in the preparation of carboxylate, the preparation of organic compounds, organic chemistry and other directions, can solve the problems of increased reagent cost, complicated extraction process, increased energy cost, etc., and achieves low equipment requirements and purification. The effect of simple process and low safety hazard

Inactive Publication Date: 2009-12-30
湖南大拇指生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] To sum up, at present, most of the raw materials for extracting chlorogenic acid are dried, which are some Chinese herbal medicines and materials that are not rich in resources, and the extraction process is relatively complicated.
This type of method has the following disadvantages: it must be dried before pumping, which increases energy costs, and chlorogenic acid will degrade part of it, and materials with insufficient resources will also increase transportation costs.
There are too many extraction steps, more reagents are used, and more reagents are recovered, which increases the cost of reagents
In addition, there are security risks

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Add 150kg of hydrochloric acid solution (0.1mol / L HCl, 20% ethanol) to 300kg of fresh sweet potato leaves with a water content of 81%, mince, extract at room temperature for 5 hours, add granular activated carbon for 1 hour after solid-liquid separation, concentrate under reduced pressure and decolorize Afterwards, extract the alcoholic water extract to 1L, and then absorb 50L of the eluate through KLFC-150 macroporous resin. Concentrate the eluate properly to 1L, adjust the pH to 3 and the temperature to 10°C for 24 hours to obtain chlorogenic acid crystals. Chlorogenic acid content is 90.8%.

Embodiment 2

[0034] Add 100kg of hydrochloric acid solution (0.1mol / L HCl, 20% ethanol) to 200kg of fresh sweet potato leaves with a water content of 85%, mince, extract for 3 hours at room temperature, add powdered activated carbon for 30 minutes after solid-liquid separation, concentrate under reduced pressure and decolorize After the alcoholic water extract to 1.5L, then adsorbed by KLFC-150 macroporous resin to obtain 60L of eluate, properly concentrate the eluate to 1L, adjust the pH to 3 and the temperature to 10°C for 24h to obtain chlorogenic acid crystals , the content of chlorogenic acid is 94.3%.

Embodiment 3

[0036] Add 150kg of hydrochloric acid solution (0.1mol / L HCl, 20% ethanol) to 600kg of fresh sweet potato leaves with a water content of 85%, mince, extract for 5 hours at room temperature, add granular activated carbon for 30 minutes after solid-liquid separation, concentrate under reduced pressure and decolorize Afterwards, 20L of alcohol-water extract was obtained, then extracted with ethanol, concentrated under reduced pressure, and the volume of the extract was concentrated to 1L, and then absorbed by KLFC-150 macroporous resin to obtain 40L of eluate, which was properly concentrated to 1L. Adjust the pH to 3 and the temperature to 5°C for 24 hours to obtain chlorogenic acid crystals with a chlorogenic acid content of 99.5%.

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PUM

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Abstract

The invention relates to a production method for extracting high-purity chlorogenic acid from sweet potato leaves. Fresh sweet potato leaves of which the water ratio is about 80 percent are extracted at normal temperature by using 0.1mol / L of hydrochloric acid solution and 20 percent of ethanol without any drying processing; the obtained product is filtered to obtain extracting solution; active carbon is added into the extracting solution; the mixture is discolored and absorbed by KLFC-150 macroporous resin; and an eluent is concentrated to obtain a chlorogenic acid product. The operating technology has the main characteristics of lixiviating of the hydrochloric acid solution along with direct use for raw materials without drying, less energy consumption, less use of organic solvents, environmental protection, safety, low production cost and high yield.

Description

technical field [0001] The invention relates to a technology for rapidly extracting high-purity chlorogenic acid from sweet potato leaves, and belongs to the technical field of natural product chemistry. Background technique [0002] Chlorogenic acid, also known as coffee tannic acid, is a condensed acid formed by caffeic acid and quinic acid. It belongs to phenylpropanoid compounds. It is a natural antioxidant produced by cells itself and an activator of cell metabolism. immunity. Studies in recent years have shown that chlorogenic acid has pharmacological effects on the digestive system, blood system and reproductive system, and has a wide range of anti-bacterial and anti-inflammatory, choleretic, hemostasis and increased white blood cell counts. It has a significant inhibitory effect on Staphylococcus aureus, hemolytic streptococcus, Shigella, and typhoid bacillus; it has a significant effect on leukocyte feeding syndrome caused by radiotherapy and chemotherapy; oral adm...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C67/56
Inventor 李光锋
Owner 湖南大拇指生物药业有限公司
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