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Smoked plum extractive and wild jujube seed extractive compound preparation as well as preparation method and application thereof

A technology for extracts and compound preparations of jujube kernels, applied in the field of biomedicine, can solve problems such as unseen and small proportion of flavonoids, and achieve the effects of enhancing anti-inflammatory ability, ensuring food safety, and improving non-specific immunity.

Active Publication Date: 2009-12-09
何诚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Domestically, there have been literatures and patents on the treatment of viral myocarditis and viral hepatitis B with traditional Chinese medicine prescriptions containing Suanzaoren, and abroad there are literature reports on the antifungal and virus-resistant effects of the bark, leaf extract or fruit of Suanzao jujube, among which Most of the jujube seed extracts are obtained through water or alcohol extraction, and its active ingredients mainly contain jujube seed saponin, and the proportion of flavonoids is small, and none of them have passed through 70%-75% ethanol. The extract obtained by n-butanol extraction is used as a drug against poultry herpes virus, infectious bursal virus drug or as a literature report or patent against poultry Escherichia coli and chicken mycoplasma

Method used

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  • Smoked plum extractive and wild jujube seed extractive compound preparation as well as preparation method and application thereof
  • Smoked plum extractive and wild jujube seed extractive compound preparation as well as preparation method and application thereof
  • Smoked plum extractive and wild jujube seed extractive compound preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 Suanzaoren extract

[0031] Grind 100 g of Semen jujuba (purchased from Changda Medicine Drink Co., Ltd., Anguo City, Hebei Province) and pass it through a 10-mesh sieve. Add 6 times the amount of Semanthus jujube seed (mL / g) to the sifted product, soak in petroleum ether for 6 hours, degrease 6 times, and degrease After complete evaporation of petroleum ether. Then add 6 times the amount (mL / g) of Jujube Semen to soak in 75% alcohol in the dregs, soak for 4 hours each time, and extract 4 times continuously. After removing the alcohol, add 3 times the amount (mL / g) / g) of water was stirred and mixed evenly, then added water-saturated n-butanol with 4 times the amount (mL / g) of Semen Semen Semen Semen Semen Jujubee, and extracted continuously for 4 times, and concentrated to obtain 5g Semen Semanthus Semen Semen Semen Extract, with an extraction rate of 5%. .

Embodiment 2

[0032] The preparation of embodiment 2 ebony extract

[0033] Take 4Kg ebony plum (purchased from Changda Medicine Beverage Co., Ltd., Anguo City, Hebei Province), add 4 times the amount (mL / g) of ebony plum in 75% ethanol each time, soak and extract 2 times, each time for 8 hours, and extract the ebony plum together with one And pour it into a three-necked flask, place it on an electronic temperature-regulating electric heating mantle, boil for 1 hour, take the extract and filter it with suction, and combine the filtrates to concentrate under reduced pressure to obtain the ebony extract extract.

Embodiment 3

[0034] The preparation of embodiment 3 compound ebony jujube kernel oral liquid

[0035] Get the Jujube Seed extract extract 2g of Example 1, the black plum extract extract 18g of Example 2, place respectively in a 100mL volumetric flask, dissolve with 20mL75% alcohol respectively, add 0.1g Menthol (purchased in Anguo City, Hebei Province) Chang'an Chinese Medicinal Materials Co., Ltd.), and then add 80% 1,2-propanediol to make the volume up to the mark, and the prepared medicine contains 200 mg of crude drug per milliliter. Which contains black plum extract 180mg; Suanzaoren extract 20mg; Suanzaorin A content is 0.07mg / mL; citric acid content is 0.13mg / mL.

[0036] The compound is a dark brown liquid with a pH value of 1.5-2.0 and a relative density of 1.06.

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Abstract

The invention provides a smoked plum extractive and wild jujube seed extractive compound preparation, comprising the following components according to parts by weight: smoked plum alcohol 49-90, wild jujube seed alcohol 9-50, and menthol crystal 0.2-4.5. The smoked plum extractive and wild jujube seed extractive compound preparation is prepared into soluble powder, granule, oral liquid, injection or lyophilized powder for injection by extracting smoked plum and wild jujube seed with 70-75% alcohol in a proper way to obtain crude extract and regular auxiliary material or carrier according to regular preparation method. The compound preparation can be applied in preparing medicament for preventing and curing poultry and livestock virus diseases or bacteria diseases, having the characteristics of good curing effect, quick effect, high security, no residue, environment protection and the like.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the preparation method and application of ebony extract, jujube seed extract and compound preparation. Background technique [0002] Since the beginning of the 21st century, major livestock and poultry diseases have continued to break out all over the world, which not only seriously hindered the healthy development of animal husbandry, but also caused a series of public health emergencies. The epidemic has caused great harm to people's health and social stability. Therefore, the research and creation of new biological veterinary drugs has become a major demand to ensure the development of my country's animal husbandry, maintain people's health and life safety, maintain social stability and promote economic development. [0003] Fructus Mume is processed from the dried immature fruit of Prunus mume (Sieb.) Sieb.et Zucc., a plant of Rosaceae. Other names include plum fruit,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P31/16A61P31/14A61P31/22A61P31/00A61P31/04A61K31/045
Inventor 王月琴何诚彭剑飞张发明李应超李树梅
Owner 何诚
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