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Vascular stent material of tissue engineering and manufacturing method thereof

A vascular stent and tissue engineering technology, which is applied in the field of tissue engineering vascular stent materials and its production, can solve problems such as the difficulty in controlling the precise composition of bacterial cellulose membranes, and achieve the effects of improving the success rate of transplantation, accelerating complete fusion, and uniform and complete pores

Active Publication Date: 2009-11-25
HAINAN YEGUO FOODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, the oxygen concentration and partial pressure on the surface of the mold material are not precisely controlled, so it is difficult to control the precise composition of the bacterial cellulose film

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Preparation of Human External Carotid Artery Tissue Engineering Vascular Scaffold Materials

[0075] 1) Blueprint

[0076] Based on the morphology and structure of the external carotid artery of an adult (>18 years old), a hollow tubular tissue engineering vascular stent material with an inner diameter of 5 mm, an outer diameter of 6 mm and an effective length of 500 mm was prepared.

[0077] 2) Mold material

[0078] Medical oxygen-permeable silica gel with a porosity of 50% was selected as a raw material to prepare a hollow tubular tissue engineering vascular stent mold with an inner diameter of 4 mm and an outer diameter of 5 mm.

[0079] 3) Model strains

[0080] Select Gluconacetobacter xylinum 323 as the model strain, activate the model strain to prepare Acetobacter xylinum seed mash with a concentration of 5%, and inoculate the Acetobacter xylinum seed mash into the coconut water fermentation medium to make wood-containing Initial fermentation broth of an acti...

Embodiment 2

[0099] Preparation of human arm radial artery tissue engineering stent material

[0100] 1) Blueprint

[0101] Based on the morphology and structure of the radial artery in the arm of an adult (>18 years old), a hollow tubular tissue engineering vascular stent material with an inner diameter of 1 mm, an outer diameter of 2 mm, and an effective length of 200 mm was prepared.

[0102] 2) Mold material

[0103]Medical oxygen-permeable silica gel with a porosity of 50% was selected as a raw material to prepare a hollow tubular tissue engineering vascular stent mold with an inner diameter of 0.5 mm and an outer diameter of 1 mm.

[0104] 3) Model strains

[0105] Select Gluconacetobacter xylinum 323 as the model strain, activate the model strain to prepare Acetobacter xylinum seed mash with a concentration of 5%, and inoculate the Acetobacter xylinum seed mash into the coconut water fermentation medium to make wood-containing Initial fermentation broth of an active strain of Ace...

Embodiment 3

[0124] Preparation of human lower extremity vein tissue engineering vascular scaffold material

[0125] 1) Blueprint

[0126] Based on the morphology and structure of the lower limb veins of adults (>18 years old), a hollow tubular tissue engineering vascular scaffold material with an inner diameter of 3 mm, an outer diameter of 4 mm, and an effective length of 500 mm was prepared.

[0127] 2) Mold material

[0128] Medical oxygen-permeable silica gel with a porosity of 50% was selected as a raw material to prepare a hollow tubular tissue engineering vascular stent mold with an inner diameter of 2 mm and an outer diameter of 3 mm.

[0129] 3) Model strains

[0130] Select Gluconacetobacter xylinum 323 as the model strain, activate the model strain to prepare Acetobacter xylinum seed mash with a concentration of 5%, and inoculate the Acetobacter xylinum seed mash into the coconut water fermentation medium to make wood-containing Initial fermentation broth of an active strain...

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Abstract

The invention discloses a vascular stent material of tissue engineering and manufacturing method thereof, which comprises selecting acetobacter xylinum as a model strain; using oxygen permeable materials to prepare hollow tubular dies which are arranged in the fermentation liquid and introduced with oxygen for fermentation until the bacterial celluloses completely cover the outer surface of the dies and the required porosity, thickness, uniformity and structural characteristic are reached to obtain a vascular stent raw material of tissue engineering; removing impurities to reduce the impurity rate to below 0.05%, sterilizing and packaging to prepare the vascular stent material of tissue engineering. The invention is simple in process and safe and has no toxic and side effect, and the material has more uniform spatial structure, more suitable porosity, uniform texture of each material in batches by controlling the fermentation process to effectively improve the quality and favourably achieve the scaled production.

Description

technical field [0001] The invention relates to a tissue engineering vascular stent material and a production method thereof, belonging to the technical field of bioengineering. Background technique [0002] With the development of science and technology, the use of tissue engineering to construct organs or even body systems in vitro to replace diseased, necrotic or missing tissues makes it possible to regenerate human tissues and organs, thus pointing out the fundamental solution to the donor problem of organ transplantation. the direction of scientific development. [0003] Blood vessels are one of the essential organs of the human body, and they are also the basic structure for the survival of the life cycle. In clinical surgery, most patients need vascular reconstruction, especially the treatment of cardiovascular and cerebrovascular diseases such as coronary heart disease and peripheral blood vessels urgently needs vascular grafts to replace damaged blood vessels. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/56A61L27/58A61F2/06A61L27/20
Inventor 钟春燕王青龙钟宇光
Owner HAINAN YEGUO FOODS
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