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Technology method for producing ethyl lactate from ammonium lactate

A technology of ethyl lactate and ammonium lactate, applied in the field of ethyl lactate synthesis, to achieve the effects of lower production costs, mild reaction conditions, and environmental friendliness

Inactive Publication Date: 2009-11-11
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant report on the biocatalytic synthesis of ethyl lactate using ammonium lactate as a raw material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] Get 0.2135 grams of ammonium lactate and 2.2038 grams of ethanol in a 50 milliliter conical flask with a grinding mouth stopper, then add 6 milliliters of tert-butanol, and 0.0618 grams of enzyme N435 (Candida antarctica lipase B, purchased from Novozymes) Add it into a triangular flask with a grinding mouth stopper, seal the bottle mouth with a tetrafluoroethylene sealing tape and place it in a constant temperature water bath shaker with a shaker rotation speed of 150 rpm, a reaction temperature of 75 degrees, and a reaction time of 24 hours. The amount of ethyl lactate produced by the reaction was determined by gas chromatography, and cyclohexanone was used as an internal standard, and the yield of ethyl lactate was 32.0%.

example 2

[0018] Take 0.2127 g of ammonium lactate and 2.2066 g of ethanol in a 50 ml conical flask with a ground stopper, then add 6 ml of n-hexane and 0.0413 g of enzyme N435 (Candida antarctica lipase B, purchased from Novozymes) Put it into a triangular flask with a grinding mouth stopper, seal the bottle mouth with a tetrafluoroethylene sealing tape and place it in a constant temperature water bath shaker with a shaker rotation speed of 150 rpm, a reaction temperature of 60 degrees, and a reaction time of 24 hours. The amount of ethyl lactate produced by the reaction was determined by gas chromatography, using cyclohexanone as an internal standard, and the yield of ethyl lactate was 28.90%.

example 3

[0020] Get 0.2459 grams of ammonium lactate and 0.7753 grams of ethanol in a 50 milliliter conical flask with a grinding mouth stopper, then add 6 milliliters of cyclohexane and 0.0616 grams of enzyme Lipex (Humicola tomentosa lipase, purchased from Novozymes) Put it into a triangular flask with a grinding mouth stopper, seal the bottle mouth with a tetrafluoroethylene sealing tape and place it in a constant temperature water bath shaker with a shaker rotation speed of 150 rpm, a reaction temperature of 50 degrees, and a reaction time of 20 hours. The amount of ethyl lactate produced by the reaction was determined by gas chromatography, and cyclohexanone was used as an internal standard, and the yield of ethyl lactate was 28.7%.

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Abstract

The invention relates to a technology method for producing ethyl lactate from ammonium lactate. The technology method takes the ammonium lactate as a material and adopts enzyme catalysis for preparing the ethyl lactate and comprises the following steps of: adding the ammonium lactate and ethanol in a reactor, sequentially adding a solvent and an enzyme catalyst, wherein the mass proportioning ratio of the ammonium lactate to the ethanol is 1:3-11, the usage of the enzyme catalyst accounts for 14-29 percent of the mass of the ammonium lactate, and the adding quantity of the solvent in the ammonium lactate is 18-28.5ml / g; and sealing and putting the reactor in a constant temperature water bath shaker for reaction for 15-24 hours at temperature of 50-75 DEG C to obtain the ethyl lactate, wherein the enzyme catalyst is candida cylinder lipase, fuzzy humic mould lipase, candida antarctica lipase B or thermophilic fungi lipase. The method takes biological enzyme as a cytalyst and has the advantages of having moderate reaction conditions, being environment-friendly and the like, and the yield reaches over 30 percent; and the method omits lactate acidulating process of lactate salts, shortens the preparation process of the ethyl lactate and lowers the production cost of the ethyl lactate.

Description

technical field [0001] The invention relates to a method for synthesizing ethyl lactate, in particular to a process for producing ethyl lactate from ammonium lactate. Background technique [0002] Ethyl lactate is widely used in the fields of medicine, pesticide and other fine chemicals. It is a commonly used food spice, and can be used as a tablet lubricant in the pharmaceutical industry and an intermediate of certain medicines. It is also an important raw material for the production of wine and food. Moreover, ethyl lactate has the advantages of non-toxicity, good solubility, low volatility and biodegradability, and is a "green solvent" with great development value and application prospect. [0003] At present, the industrial production of ethyl lactate mainly uses lactic acid as raw material, and lactic acid is obtained by fermentation. Traditional fermentation uses CaCO 3 As a neutralizing agent, first generate calcium lactate, and then use H 2 SO 4 Acidification, thi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/62
Inventor 高静王营营
Owner HEBEI UNIV OF TECH
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