Gargle for relieving pain for oral inflammation disease
A technology for oral inflammation and gargle, which is applied in the field of medicine and achieves the effects of ensuring chemical stability, increasing water solubility and increasing stability
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Embodiment 1
[0033] The following pharmaceutical composition for relieving pain and anti-inflammation of oral inflammatory disease is prepared according to the following ratio.
[0034] Diclofenac sodium (DS) 1.23g
[0035] HP-β-CD 4.43g
[0036] ---------------------------------
[0037] Add water for injection to 100.00ml
[0038] Preparation Process
[0039] Take 4.43g of HP-β-CD, add about 100ml of water for injection, heat to 80°C on a magnetic stirrer, stir to dissolve, slowly add 1.23g of diclofenac sodium under stirring (about 1000rpm), keep warm at 50°C-80°C ℃, stirring for 2h; stop heating, continue to stir to room temperature, and obtain DS-HP-β-CD clathrate solution. Take this solution and place it in the refrigerator for 12 hours, filter with suction and wash the precipitate, and dry the precipitate at 60°C. Weigh and determine its content. Obtain the diclofenac sodium hydroxypropyl-β-cyclodextrin inclusion in the composition of the present invention.
Embodiment 2
[0041] prescription
[0042] DS--HP-β-CD 1.23g (equivalent to containing diclofenac sodium 0.8g)
[0043] Lidocaine Hydrochloride 0.20g
[0044] Borax 15g
[0045] Boric acid 7.5g
[0046] Glycerin 35ml
[0047] Sodium bicarbonate 15g
[0048] Vitamin B12 0.06g
[0049] Tromethamine 0.60g
[0050] -----------------------------------
[0051] Add water for injection to 1000.00ml
[0052] Preparation Process
[0053] Take the prescribed amount of DS--HP-β-CD, add an appropriate amount of water for injection, add lidocaine hydrochloride, borax, boric acid, glycerin, sodium bicarbonate, vitamin B12, and tromethamine in sequence after fully dissolved, and heat to 80°C Stir for 15 minutes until it is fully dissolved, then cool down to 40°C, and make up to the full amount with water for injection to obtain the main drug stock solution of the composition of the present invention, whose pH value is 8.2.
Embodiment 3
[0055] prescription
[0056] DS--HP-β-CD 1.23g (equivalent to containing diclofenac sodium 0.8g)
[0057] Lidocaine Hydrochloride 0.20g
[0058] Borax 15g
[0059] Boric acid 7.5g
[0060] Glycerin 35ml
[0061] Sodium bicarbonate 15g
[0062] Vitamin B12 0.06g
[0063] Tromethamine 0.60g
[0064] Sucralose 6.8g
[0065] Peppermint essence 5ml
[0066] Sodium Benzoate 0.5g
[0067] ---------------------------------------
[0068] Add water for injection to 1000.00ml
[0069] Preparation Process
[0070] Take the prescribed amount of DS--HP-β-CD, add an appropriate amount of water for injection, add lidocaine hydrochloride, borax, boric acid, glycerin, sodium bicarbonate, vitamin B12, and tromethamine in sequence after fully dissolved, and heat to 80°C Stir for 15 minutes until completely dissolved, then lower the temperature to 40°C to obtain the main drug stock solution of the composition of the present invention. Then add sucralose, peppermint essence, sodium be...
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