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Sugar-free granular preparation of daphniphyllum-polygonum, application and preparation method thereof

A granule preparation, sugar-free technology, applied in the field of medicine, can solve the problems of complex mechanism of action of traditional Chinese medicine, and achieve the effects of good patient compliance, uniform particle size, and fast dissolving and dispersing speed.

Active Publication Date: 2009-10-07
HAIKOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flavonoids are the king medicine. Modern medical research shows that the main active ingredients of Flavonoids are flavonoids and alkaloids, among which flavonoids include rutin, quercetin, isorhamnetin, etc., and rutin is its main effect One of the ingredients, its content can represent the content of active ingredients in the drug, but the mechanism of action of traditional Chinese medicine is more complex, not a single ingredient produces the main effect, in the same prescription of medicinal materials, the content of various active ingredients has a certain relationship of

Method used

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  • Sugar-free granular preparation of daphniphyllum-polygonum, application and preparation method thereof
  • Sugar-free granular preparation of daphniphyllum-polygonum, application and preparation method thereof
  • Sugar-free granular preparation of daphniphyllum-polygonum, application and preparation method thereof

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Effect test

Embodiment 1

[0024] Example 1 Screening of adjuvant materials for Fengyao granule preparations of the present invention

[0025] Common excipients for sugar-free granules include dextrin, soluble starch, microcrystalline cellulose, lactose, mannitol, and chitosan. Polygonum dry paste powder is a water extract. According to the bulk density of Polygonum dry paste powder, select auxiliary materials similar to its bulk density: dextrin, soluble starch, lactose and mannitol, so that Polygonum dry paste powder and auxiliary materials can be granulated Easy to mix homogeneously in the equipment. The type and amount of auxiliary materials directly affect the yield of production, and the auxiliary materials are screened by measuring the molding rate and moisture absorption rate of particles made of different auxiliary materials.

[0026] According to the amount of crude drug contained in each bag of the original prescription and the amount of sugar-free granules to be made, the ratio of the dry...

Embodiment 2

[0033] Example 2 The prescription of Fengyao granule preparation of the present invention

[0034] The water-extracted dry paste powder of maple and Polygonum provided by the present invention is prepared by water extraction of maple and Polygonum caprifolia with a ratio of mass and number of 2: 1. The specific method is as follows: take 20000g of maple and Polygonum capericum and 10000g of Polygonum capsicum, add water for the first time Double extraction for 1.5 hours, add water for the second time and extract by 4 times for 1 hour, after combining the two extracts, concentrate to a relative density of 1.26 ± 0.01 (boiling measurement), dry under reduced pressure (0.07-0.08MPa), and obtain the water extract of Polygonum japonica dry cream powder, and crushed into dry cream powder.

[0035] The present embodiment provides a preferred prescription of Fengyao granule preparation of the present invention as follows:

[0036] Polygonum dry paste powder 1000g

[0037] Mannitol ...

Embodiment 3

[0043] Example 3 The preparation method of Fengyao granule preparation of the present invention

[0044] This example is the preparation method of the Fengyao granule preparation of the present invention.

[0045] The preparation method of the maple Polygonum granule preparation provided by the present invention, its concrete steps are as follows:

[0046] (1) Pre-treatment of medicinal materials: Take 20000g of Auranthus japonica and 10000g of Polygonum capericum, wash them, cut them into 5cm long pieces, and put them in a multifunctional extractor.

[0047] (2) Extraction: extract 2 times, add 6 times of water for the first time, extract for 1.5 hours, add 4 times of water for the second time, extract for 1 hour (average 2kg pressure, time after boiling). The total amount of water used for extraction is 10 times, the amount of water added for the first time should be more, because the medicinal materials absorb water before decoction, and there is no problem of water abs...

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Abstract

The invention provides a sugar-free granular preparation of daphniphyllum-polygonum, and the application and a preparation method, including water-extracting dry ointment powder of daphniphyllum calycinum and polygonum hydropiper, mannitol and dextrin with the mass ratio of 1-5:1-10:1-5. The granular preparation of daphniphyllum-polygonum is simple in granulating technology, the granulating process adopts the ebullated bed one-step granulation technology which reduces dust pollution in industrial production and meets the modernization requirement in the preparation of Chinese traditional medicine. The obtained granular formulation of daphniphyllum-polygonum has high granulation rate, low rate of moisture absorption, high dissolving speed, good taste and high bioavailability and good patient dependence, and is especially suitable for the patients who are weak and can not eat sugar, such as the diabetic and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular, the invention relates to a sugar-free fenugreek granule preparation, its use and preparation method. Background technique [0002] The original prescription of Feng Liao traditional Chinese medicine comes from folk prescriptions in Qionghai County, Hainan Province. Use cool together to harmonize yin and yang, and work hard together to go up and down, so that the stomach and intestines are harmonized, and the up and down are normal. Flavonoids are the king medicine. Modern medical research shows that the main active ingredients of Flavonoids are flavonoids and alkaloids, among which flavonoids include rutin, quercetin, isorhamnetin, etc., and rutin is its main effect One of the ingredients, its content can represent the content of active ingredients in the drug, but the mechanism of action of traditional Chinese medicine is more complex, not a single ingredient produces the ma...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/16A61K47/40A61P1/00A61P1/02
Inventor 张志兰沙莹冯柏昌
Owner HAIKOU PHARMA FACTORY
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