Method for preparing neuro chip by taking polylactic acid as substrate

Abstract

The invention relates to a method for preparing a neuro chip by taking polylactic acid as a substrate in the technical field of biological engineering. The method comprises the following steps: firstly, spin coating of a layer of photoresist on the polylactic acid substrate; secondly, carrying out UV exposure on the photoresist subjected to spin coating; thirdly, placing the exposed device in a developing solution to remove the part of unexposed photoresist; fourthly, etching a round hole on the polylactic acid substrate by a NaOH etching agent; fifthly, sputtering gold in the round hole of the polylactic acid substrate; sixthly, removing the exposed photoresist from the device which is sputtered by the gold, and peeling off the sputtered gold on the photoresist; and seventhly, carrying out chemical mechanical planarization to ensure that the gold and an integrated circuit are well connected with each other. The method adopts the polylactic acid substrate instead of a monocrystalline silicon substrate, not only can realize functions of the prior neuro chip, but also can realize excellent biological compatibility and stable working life, compared with the prior neuro chip.

Description

technical field [0001] The invention relates to a method for preparing a chip in the technical field of bioengineering, in particular to a method for preparing a neurochip based on polylactic acid. Background technique [0002] The neural chip technology was proposed by scientists from the University of Padua in Italy on March 27, 2006. This research will help to develop advanced nerve repair technology for the treatment of nerve disorders or develop living nerve cells Organic computers that process data. The specific principle is as follows: 16,000 electronic transistors and hundreds of capacitors are installed on a silicon chip with a size of 1 square millimeter, and then brain cells are glued to the chip with a special protein found in the brain. The ion channels of the nerve cells are connected to the semiconductor material so that the nerve cell's electrical signals can be transmitted to the silicon chip. Through this protein, the electronic components on the neurochi...

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Problems solved by technology

But the disadvantage is that the monocrystalline silicon wafer does not have good biocompatibility, which will affect the working life of the entire chip, so that the function of the neural chip cannot be realized very well and stably.

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