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Pharmaceutical composition for treating female barrenness as well as preparation method and quality control method thereof

A composition and infertility technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor curative effect, large side effects and sequelae, and aggravating the suffering of patients.

Active Publication Date: 2009-07-08
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current medical and surgical treatment is not only expensive but also aggravates the pain of patients, the cure rate is not high, the recurrence is large, and the side effects and sequelae are large.
In view of the fact that most of the current western medicines act on a single target or link, resulting in poor curative effect

Method used

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  • Pharmaceutical composition for treating female barrenness as well as preparation method and quality control method thereof
  • Pharmaceutical composition for treating female barrenness as well as preparation method and quality control method thereof
  • Pharmaceutical composition for treating female barrenness as well as preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0286] Preparation of oral liquid of pharmaceutical composition:

[0287] Ingredients: Epimedium 300g, Polygonatum 240g, Dipsacus 240g, Cyperus rotundus 180g, Shichangpu 180g, Licorice 120g.

[0288] Preparation: Add 12 times the amount of water to Xiangfu and Shichangpu, distill for 6 hours to extract the volatile oil, and collect the distilled aqueous solution; add 12 times the amount of water to decoct the medicinal residue for 1 hour, and filter the liquid for use; the remaining 4 flavors are separately Decoction with 10 times the amount of water for 3 times, 2 hours each time, combine the decoction, filter, combine the filtrate with the above-mentioned liquid, concentrate under reduced pressure to a relative density of 1.10-1.12 (60°C), stand for 24 hours, and take it Ethanol was recovered from the clear liquid and concentrated to a relative density of 1.04 (20°C). After standing for 48 hours, the supernatant was taken and filtered. The filtrate was added with the above-menti...

Embodiment 2

[0291] Preparation of pharmaceutical composition mixture:

[0292] Ingredients: Epimedium 300g, Polygonatum 240g, Dipsacus 240g, Cyperus rotundus 180g, Shichangpu 180g, Licorice 120g.

[0293] Preparation: Add 8 times the amount of water and 4 times the amount of water for the above six flavors, respectively, and cook twice. After each decocting, keep at 85°C for 20 minutes, filter, combine the filtrate, and concentrate under reduced pressure to a relative density of not less than 1.06 ( 80°C), centrifuge, take the supernatant, add 200 g of sucrose, 3 g of sodium benzoate, and 0.5 g of ethyl paraben, add water to make 1000 mL, mix, and fill to obtain the mixture.

[0294] Take: 50ml twice a day.

Embodiment 3

[0296] Preparation of pharmaceutical composition syrup:

[0297] Ingredients: Epimedium 300g, Polygonatum 240g, Dipsacus 240g, Cyperus rotundus 180g, Shichangpu 180g, Licorice 120g.

[0298] Preparation: Add 12 times the amount of water to Xiangfu and Shichangpu, distill for 6 hours to extract the volatile oil, and collect the distilled aqueous solution in another container; the volatile oil is clathrated with 6 times the amount of β-cyclodextrin to synthesize an inclusion compound. Add 12 times the amount of water to decocting for 1 hour, then filter the liquid for use; the remaining 4 flavors are decocted 3 times with 10 times the amount of water for 2 hours each time, combine the decoction, filter, and the filtrate with the above medicine Combine the liquids, concentrate under reduced pressure to a relative density of 1.10-1.12 (60°C), stand for 24 hours, take the supernatant to recover ethanol and concentrate to a density of 1.18, take another 650g of sucrose and decoct it in ...

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Abstract

The invention discloses a pharmaceutical composition for the treatment of female infertility as well as a preparation method and a quality control method thereof, the composition is any one of pharmaceutically acceptable preparations such as pellet, granule, tablet, syrup, mixture, oral liquid, dripping pill, capsule and injection prepared by epimedium brevicornum, sealwort, teasel root, astragalus root, rhizome cyperi and licorice. The quality control method thereof comprises the steps of: thin-layer identification of the epimedium brevicornum, sealwort, radix dipsaci, licorice, licorice and astragalus root; HPLC content measurement of the epimedium brevicornum, radix dipsaci and licorice; measurement of total contents of flavone and saponin. The pharmacodynamical experiments include: in vivo experiment, in vitro cell experiment and clinical experiment. The experiments demonstrate that: the inventive pharmaceutical composition has the effects of warming kidney, replenishing sperm and conditioning emmenia, and the pharmaceutical composition can be used for the treatment of the female infertility.

Description

Technical field [0001] The invention relates to a pharmaceutical composition and a preparation method and quality control method thereof, in particular to a pharmaceutical composition for treating female infertility, and a preparation method and quality control method thereof. Background technique [0002] It is generally believed that couples of childbearing age live together after marriage, do not have contraception, and have a normal sexual life for more than two years (the American Obstetrics and Gynecology Textbook and the Infertility Association set the time as one year) The phenomenon that the woman has not conceived is called "infertility." . Infertility or infertility caused by the man’s cause is called "male infertility" or "male infertility", and people generally refer to it as infertility. There are many pathogenic factors for female infertility, and the pathogenesis is quite complicated. The main factor is egg maturation disorder. The main factors of male infertility...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/00A61K9/20A61P15/08
Inventor 徐玲玲年华张玉萱
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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