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Pharmaceutical combination and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, drug formulation, drug delivery, etc., can solve the problems of unsatisfactory clinical curative effect and no substantial progress in clinical research

Active Publication Date: 2011-08-31
黑龙江国药双兰星制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine has reported the treatment of liver fibrosis from different angles, but the clinical efficacy is not very satisfactory, and there is no substantial progress in clinical research

Method used

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  • Pharmaceutical combination and preparation method thereof
  • Pharmaceutical combination and preparation method thereof
  • Pharmaceutical combination and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Embodiment 1: the preparation of granule

[0168] Astragalus 510kg Salvia 200kg Curcuma 200kg Surgery 200kg

[0169] Curcuma 150kg, Yinchen 150kg, Bupleurum 150kg, peach kernel 150kg

[0170] Northern Bean Root 100kg Licorice 100kg

[0171] Take the volatile oil of the grille, atractylodes, and tulips. The distilled aqueous solution A separates the device, and the medicine residue A is set aside. , recover ethanol under reduced pressure, concentrate to a thick paste, and dry at 60°C to obtain dry paste powder A and medicinal residue B for later use; extract astragalus with water for 3 times, the time is 2, 1, and 1 hour respectively, and the water consumption is respectively 10, 8, and 8 times, combine the decoction, filter, concentrate the filtrate to 0.5 grams of medicinal materials per milliliter, and centrifuge at 3000 rpm to remove some impurities, and concentrate the supernatant to thick paste A for later use; the rest of Bupleurum, Combine the five herbs of pe...

Embodiment 2

[0172] Embodiment 2: the preparation of capsule

[0173] Astragalus 450kg Salvia miltiorrhiza 200kg Curcuma 200kg

[0174] Atractylodes macrocephala 200kg Curcuma 120kg Capillary 120kg

[0175] Bupleurum 120kg, peach kernel 120kg, bean root 80kg

[0176] Licorice 80kg

[0177] Extract volatile oil from Curcuma, Atractylodes Rhizoma Atractylodes Rhizome and Curcuma Rhizome, store the distilled aqueous solution A in another device, and add the dregs A for later use; add Danshen root to 5 times the amount of 85% ethanol and extract twice for 3 hours each time, combine the extracts, filter, and reduce Press to recover ethanol, concentrate to a thick paste, and dry at 40°C to obtain dry paste powder A and medicinal residue B for later use; extract Astragalus membranaceus 4 times with water for 1 hour each time, and use 10 times the amount of water each time, and combine Decoction, filtered, the filtrate is concentrated to 0.2 grams of medicinal materials per milliliter, centrifu...

Embodiment 3

[0178] Embodiment 3: the preparation of tablet

[0179] Astragalus 550kg Salvia 250kg Curcuma 250kg

[0180] Atractylodes atractylodes 250kg Curcuma 180kg Capillary 180kg

[0181] Bupleurum 180kg, peach kernel 180kg, bean root 120kg

[0182] Licorice 120kg

[0183] Extract volatile oil from Curcuma, Atractylodes Rhizoma Atractylodes Rhizome and Curcuma Rhizome, save the distilled aqueous solution A in another device, and use dregs A for later use; add Danshen root to 7 times the amount of 65% ethanol and extract 4 times, each time for 1 hour, combine the extracts, filter, reduce Press to recover ethanol, concentrate to thick paste, and dry at 80°C to obtain dry paste powder A and medicinal residue B for later use; add water to extract Astragalus membranaceus twice, each time for 3 hours, and water consumption is 8 times each time, and combine Decoction, filtered, the filtrate is concentrated to 0.8 grams of medicinal materials per milliliter, centrifuged at 3000 rpm to remo...

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Abstract

The present invention discloses a medicine composition which is used preventing or treating hepatic fibrosis or early hepatocirrhosis, a preparing method and a quality control method thereof. The composition is composed of ten Chinese medicine herbs of astragalus, salvia root, zedoary turmeric, bighead atractylodes rhizome, curcuma aromatica, capillary artemisia, radix bupleuri, peach kernel, rhizoma menispermi and liquorice. The methods of extracting, decocting, filtering, condensing, etc. are executed to different components in the preparing process of medicine composition for fully exerting the effective medicine. Simultaneously the invention also provides a quality control method for identifying the components of medicine composition and measuring the contents. A considerable amount of experiments shows that the medicine composition has actual curative effect for preventing or treating hepatic fibrosis or early hepatocirrhosis with safe and effective clinical use.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method thereof, in particular to a pharmaceutical composition for preventing or treating liver fibrosis or early liver cirrhosis, a preparation method and a quality control method thereof. Background technique [0002] Liver fibrosis is caused by abnormal proliferation of extracellular matrix on the basis of chronic liver damage. It is an inevitable stage in the development of liver cirrhosis. Blocking liver fibrosis may control the occurrence of liver cirrhosis. Chronic hepatitis B is the most common cause of chronic liver damage and possible liver fibrosis. Chronic hepatitis B is a common infectious disease, and more than 280 million people worldwide carry hepatitis B surface antigen (HBsAg). my country is a highly prevalent area of ​​hepatitis B. 40%-60% of the population has been infected with HBV, and 9.97% of the population (about 120 million people...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/00A61P1/16G01N30/90
Inventor 侯凤祥
Owner 黑龙江国药双兰星制药有限公司
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