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Method for benzo (alpha) pyrene removal from red clover extract using ultramicro communication technique

An ultra-fine pulverization technology, a technology of red clover, is applied in the field of extraction and application of traditional Chinese medicine, and can solve the problems of low efficiency of benzo[a]pyrene and the like

Active Publication Date: 2011-04-27
湖南春光九汇现代中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the extracts of traditional Chinese medicines are extracted with polar solvents such as water and ethanol, and it is difficult for non-polar solvents to penetrate into the extracts. Therefore, conventional extraction methods have low efficiency in removing benzo[a]pyrene from extracts of traditional Chinese medicines.

Method used

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  • Method for benzo (alpha) pyrene removal from red clover extract using ultramicro communication technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Superfine pulverization: Take the red clover extract, put it in a superfine pulverizer, pulverize it for 30 minutes, and the particle size should not exceed 75 μm, and set it aside.

[0033] 2. Extraction: Put 280kg of red clover extract into the 2T alcohol sinking tank, execute according to the "2T alcohol sinking tank standard operating procedure", stir and extract 4 times under reflux at 80-90°C, ethyl acetate and petroleum ether (boiling point 60~90 ℃) equal mass ratio solvent consumption is 6 times of the red clover extract ultrafine pulverized material quantity for the first time, and 5 times of the second to fourth times, extracting for 1 hour each time, cooling to At room temperature, stand still for the first to third times to separate the layers. The solvent layer is siphoned from the top of the tank. After the last stirring and cooling, it is released from the bottom cover, transferred to a stainless steel bucket, and allowed to stand for 2 hours to separat...

Embodiment 2

[0038] Effects of Different Grinding Methods on the Removal Efficiency of Trifolium Trifolium Benzo[a]pyrene

[0039] Experiment number

[0040] Adopt different pulverizing methods, all the other technological processes are identical with embodiment 1, and test result shows, the content of benzo[a]pyrene in the product after superfine pulverization of red clover extract is higher than that of benzo[a]pyrene in common production method product. The content of pyrene was significantly reduced, and the removal efficiency was doubled.

Embodiment 3

[0042] Effects of Different Grinding Particle Sizes on the Removal Efficiency of Trifolium Trifolium Benzo[a]pyrene

[0043] Experiment number

[0044] Adopt different pulverization time, all the other technological processes are identical with embodiment 1, and test result shows: the content of benzo[a]pyrene in the product after superfine pulverization of red clover extract reduces along with the reduction of pulverization particle diameter; When the pulverized particle size is below 75 μm, the removal efficiency of benzo[a]pyrene no longer increases, so the red clover extract is ultrafinely pulverized to a particle size of no more than 75 μm, and then passed through ethyl acetate and petroleum ether (boiling point 60-90 ℃) equal ratio solvent stirring heat reflux extraction, drying and other processes to obtain the finished product.

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Abstract

The invention discloses a method for eliminating benzo[a] pyrene in red clover extract by ultrafine grinding technology. The method has steps of crushing the red clover extract into granules having grain diameter no more than 75 um by ultrafine grinding, stirring the grinded extract by solvent of acetic ester and petroleum ether having equivalent mass ratio, extracting by hot reflux, drying, and thereby the product is obtained. The invention obviously improves elimination rate for benzo[a] pyrene in red clover extract.

Description

technical field [0001] The invention belongs to the technical field of extraction and application of traditional Chinese medicines, and in particular relates to a method for removing benzo[a]pyrene from red clover extract by applying ultrafine pulverization technology. Background technique [0002] Benzo[a]pyrene, also known as 3,4-benzopyrene. It is a polycyclic aromatic hydrocarbon composed of 5 benzene rings with the molecular formula C 20 h 12 , with a molecular weight of 252. The structural formula is shown in the figure below. [0003] Benzo[a]pyrene is a light yellow needle crystal at room temperature, which can be divided into monoclinic crystal or orthorhombic crystal. It is stable in nature, with a boiling point of 310-320°C (10mm Hg), a melting point of 179-180°C, and a solubility in water of 0.004~0.012mg / L, easily soluble in cyclohexane, hexane, benzene, toluene, xylene, acetone and other organic solvents, slightly soluble in ethanol and methanol. When benz...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48
Inventor 蔡光先朱立华唐正平董绍象
Owner 湖南春光九汇现代中药有限公司
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