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Folic acid pellet and preparation method thereof

A technology of folic acid pellets and folic acid, which is applied in the field of medicine and food, can solve the problems of long disintegration time, gastric mucosa irritation, low bioavailability, etc., and achieves the effects of good effectiveness, reduced dosage times and high bioavailability

Inactive Publication Date: 2009-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently developed folic acid products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which has certain irritation to the gastric mucosa; low bioavailability, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the following ingredients for the recipe

[0034] folic acid 0.4g starch 96.6g Hydroxypropylmethylcellulose 3g

[0035] Prepare pellet formulations as follows:

[0036] (1) Get the folic acid of above-mentioned formula amount and add starch, pulverize to micronized grade with ball mill, mix;

[0037] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0038] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0040] Take the following ingredients for the recipe

[0041] folic acid 2.5g starch 93.5g Polyvinylpyrrolidone 4g

[0042] Prepare pellet formulations as follows:

[0043] (1) Get the folic acid of above-mentioned formula amount and add starch, pulverize to micronized grade with ball mill, mix;

[0044] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0045] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0047] Take the following ingredients for the recipe

[0048] folic acid 5g Crystalline Cellulose 93g Hydroxypropylmethylcellulose 2g

[0049] Prepare pellet formulations as follows:

[0050] (1) Take the folic acid of the above-mentioned formula amount and add the crystal cellulose, pulverize it to the micronization level with a ball mill, and mix well;

[0051] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0052] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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PUM

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Abstract

The invention provides a folic acid pellet preparation composed of folic acid and medical supplementary materials. The folic acid pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of folic acid is 0.02-20 percent by weight, the content of excipients is 75-99.98 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a micropill made of folic acid and a preparation method thereof. Background technique: [0002] The important nutritional effect of folic acid on the human body has been confirmed as early as 1948. The lack of folic acid in humans or other animals can cause megaloblastic anemia and leukopenia. In addition, the study also found that folic acid is especially important for pregnant women. If folic acid is lacking in the first 3 months of pregnancy, it can lead to defects in fetal neural tube development, thereby increasing the incidence of split-brain and anencephaly. Secondly, pregnant women often supplement folic acid, which can prevent congenital malformations such as underweight newborns, premature birth, and cleft palate. [0003] Folic acid is a water-soluble B vitamin composed of pteridine, p-aminobenzoic acid and glutamic acid residues, also known as vitamin BC ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/519A61P3/02
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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