Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Penam iodide, preparation and use thereof

A technology of iodide and penicillanoate, applied in the field of chemistry, can solve the problems of tautomerism, limited industrial scale, complicated preparation and the like, and achieves the effects of convenient operation, control of production cost and high synthesis yield

Active Publication Date: 2009-05-20
QILU PHARMA HAINAN +1
View PDF1 Cites 29 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the noble metal compound nitrate is used in the reaction, and the 1,2,3-triazole silver salt complex has tautomerism, and the preparation is relatively cumbersome.
All of the above conditions limit its industrial scale production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Penam iodide, preparation and use thereof
  • Penam iodide, preparation and use thereof
  • Penam iodide, preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 13

[0039] Embodiment 1.3-Methyl-{2-oxo-4-(2-benzothiazole dimercapto)-1-azetidinyl}-butenoic acid diphenylmethyl ester

[0040] Add 500ml of toluene to a clean and dry reaction bottle equipped with a water separation device, heat the oil bath to reflux for 1 hour to remove water, and discard 50ml of toluene; when it is cooled to about 100°C, add 6,6-dihydropenicillane Acid diphenylmethyl ester-1-oxide 50g (0.13mol) and 2-mercaptobenzothiazole 21g (0.128mol), heating temperature to 130-140°C, reflux to separate water, control the reflux speed in the middle process, stir the reaction 2 ~3 hours later, the reaction was completed after sampling was monitored by HPLC. Reflux to drop about 400ml of toluene or water mixture, cool to 40°C, concentrate under reduced pressure, add 800ml of isopropyl ether to dissolve, stand in an ice bath for 20 hours to crystallize, precipitate a white solid, filter, and recover the mother liquor 65g of the product was obtained, the melting point was 78-...

Embodiment 22

[0041] The preparation of embodiment 2.2β-iodomethylpenicillanic acid diphenylmethyl ester

[0042]Add 36g (0.068mol) of the disulfide ring-opened product of Example 1 and 500ml of dichloromethane into a clean flask, stir until the solid is completely dissolved, cool to -5-0°C, add 10g of sodium nitrite (0.14mol) and 150ml of Sodium nitrite solution prepared with water was slowly added dropwise into 180 ml of 6N hydrochloric acid solution under vigorous stirring, and the reaction was monitored by HPLC. Control the reaction temperature at 0-5°C, react for 2 hours, let stand, and separate the organic phase; extract the water phase with 100ml of dichloromethane; combine the organic phases, wash with water, 10% sodium bicarbonate solution, and saturated sodium chloride Solution wash. Cool down to -5~0°C.

[0043] Dissolve 16.6g (0.10mol) of sodium iodide in 300ml of acetone, cool down to 5°C and add to the above dichloromethane feed solution. After stirring well, add 6g (0.10mol...

Embodiment 32

[0044] Example 3.2 Preparation of α-methyl-2β-(1,2,3-triazol-1-yl)methylpenicillane-3α-diphenylmethyl carboxylate-1,1-dioxide

[0045] The feed liquid of 2β-iodomethylpenicillanic acid diphenylmethyl ester obtained in Example 2 was cooled to 0° C., 85 ml of glacial acetic acid was added, and after stirring evenly, 20 g of potassium permanganate ((0.127 mol) was added in batches several times. , then reacted at room temperature for 3 to 4 hours.In the reaction solution, 30% hydrogen peroxide was added dropwise until the reaction solution became colorless, filtered, washed with a small amount of dichloromethane, and the organic phase was separated, and the aqueous phase was extracted with 100ml of dichloromethane; The dichloromethane phase is washed with water and saturated sodium chloride solution successively. The dichloromethane feed liquid containing product is obtained, and the dichloromethane is distilled out under reduced pressure, and filtered to obtain the crude product,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an intermediate iodide in the synthesis of Tazobactam, and a preparation method and the application thereof in preparing Tazobactam, and discloses the structural formula (I) of 2Beta-iodomethyl penicillanic acid ester. The invention has unique technique, stable product quality, mild technique condition and high yield, is easy to be controlled, requires relatively low production cost, reduces environmental pollution, needs no special equipment and is suitable for industrialized mass production.

Description

technical field [0001] The invention relates to a tazobactam intermediate iodide and a synthesis method thereof, as well as the application of the intermediate to prepare tazobactam, belonging to the field of chemical technology. Background technique [0002] [0003] The combined application of β-lactam inhibitors and enzyme-resistant β-lactam antibiotics has enhanced the antibacterial activity of the latter and expanded the antibacterial spectrum, and has become an important means to improve the efficacy of β-lactam antibiotics. Tazobactam (Tazobactam, Figure 1) is currently recognized as the β-lactamase inhibitor with the broadest antibacterial spectrum, the best resistance, the best clinical application effect, and the most promising. Due to the excellent properties of tazobactam, the research on its synthesis and clinical application has been very active at home and abroad. With the continuous improvement of the level of organic synthesis, its synthesis route and pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D499/86C07D499/04
CPCY02P20/55
Inventor 王树鹏于志海李保勇董廷华吴柯
Owner QILU PHARMA HAINAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com