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Fluorescent chemical sensor for furadantin detection

A chemical sensor, nitrofurantoin technology, applied in the field of fluorescent sensors, can solve the problems of loss of fluorescent carrier, failure to provide sensor analysis characteristics, etc., and achieve the effect of short fluorescent response time, simple structure and large amplitude

Inactive Publication Date: 2009-05-13
焦广旭 +6
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guo Juliang et al. embedded pyrenebutyric acid in cellulose acetate to make a nitrofurantoin optical fiber sensor. Except that the fluorescent carrier may be lost, they did not provide detailed analysis characteristics of this sensor.

Method used

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  • Fluorescent chemical sensor for furadantin detection
  • Fluorescent chemical sensor for furadantin detection
  • Fluorescent chemical sensor for furadantin detection

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] (1) Sample preparation

[0015] 1.0 g of the compound aminopyrene was dissolved in 15 ml of anhydrous DMF (dimethylformamide), and 0.60 ml of triethylamine was added. 0.40 ml of methacryloyl chloride was added dropwise under vigorous stirring, and after the drop was completed, the stirring reaction was continued at room temperature for 4 hours. After the reaction was finished, the precipitate generated was removed by filtration, the filtrate was collected, and the solvent was removed under reduced pressure to obtain 1.10 g of taupe solid methacrylamidopyrene, with a yield of 72.6%, M + =285.

[0016]

[0017] The fluorescent molecules of the methacrylamide-based pyrene photopolar film contain carbonyl groups and imino groups, which are easy to polarize and are sensitive to acidic solutions. Such as figure 2 As shown, the fluorescence intensity of the methacrylamido-pyrene optode film is greatly affected by pH when the pH is higher than 5.0 or lower than the pH is...

experiment example 1

[0023] Experimental example 1: Place the prepared sensing film in the detection cell, inject the sample solution into the detection cell with a syringe, measure the fluorescence intensity at the emission wavelength of 424 nm when the maximum excitation wavelength is fixed at 366 nm, and the recording film and the sample solution reach equilibrium fluorescence intensity at time. After each measurement, use a syringe to inject a blank solution to clean the methacrylamido-pyrene photoelectrode film, so that its fluorescence intensity returns to the initial value for the next measurement. Plotting the fluorescence response of different concentrations of nitrofurantoin solutions for the fluorescence intensity of the optode membrane Figure 4 , when the concentration of nitrofurantoin is 1.0×10 -6 -1.0×10 -4 mol l -1 When between, the calibration curve is shown in Figure 4 , the correction equation is F 0 / F=1.007+8142.200[A](r=0.9969), which can be used as a sensor to determi...

experiment example 2

[0024] Experimental Example 2: Place the quartz glass slide attached with the optode film in the detection cell, and perform fluorescence measurement on a PerkingElmer LS55 fluorescence instrument with a computer data processing system. The light source is a 150W xenon lamp, and the detector is an R928F infrared-sensitive photomultiplier tube. The sample solution is injected into the detection cell with a syringe, and a stable fluorescence intensity value can be obtained after the optode membrane and the sample solution reach equilibrium. Fluorescence chemical sensor of the present invention can be applied to the mensuration of nitrofurantoin, such as figure 1 As shown, its emission spectrum is obtained by fixing the excitation wavelength at 366nm. The concentration of nitrofurantoin from top to bottom is (1) 0, (2) 4.0×10 -5 moll -1 , (3)6.0×10 -5 mol l -1 , (4)8.0×10 -5 mol l -1 , (5)1.0×10 -4 mol l -1 , (6)2.0×10 -4 mol l -1 .

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Abstract

The invention discloses a fluorescence chemical sensor for detecting nitrofurantoin. 0.1-0.2ml of sensing film solution is coated on a polyfluortetraethylene board and is covered by a silylanized glass slide, and the fluorescence chemical sensor is manufactured after being polymerized by ultraviolet light and dried in room temperature, wherein, the sensing film solution is prepared by a method as follows: 15mg of methacrylate amide pyrene is solved in 0.2ml of N, N-dimethyl formamide; and 200mg of acrylamide, 0.4ml of hydroxyethyl methacrylate, 0.15ml of cross linker, 0.2ml of trolamine and 0.3ml of photosencitizer are added sequentially. The sensor has simple structure, good stability, the short responding time and the large extend of fluorescence and can be applied to the in-situ real-time detection of the nitrofurantoin, and the sensor has the high sensitivity, good selectivity and very wide application prospect.

Description

technical field [0001] The invention relates to a fluorescent sensor, in particular to a fluorescent chemical sensor for detecting nitrofurantoin. Background technique [0002] Aromatic fused ring compounds pyrene and other derivatives are a class of electronic materials with specific properties. The research on their luminescent properties and other photophysical properties is an extremely active topic, because pyrene and other derivatives are used in laser dyes. , biological fluorescent probe molecules, liquid crystal display materials, organic and inorganic fluorine and semiconductor materials and electroluminescent devices have been widely used. At the same time, pyrene has good stability and high quantum yield, so it is very suitable to be used as a fluorescent carrier to prepare photochemical sensors. [0003] Nitrofurantoin (NFN), the molecular structure is as follows [0004] [0005] It is a drug used to treat urinary tract infections. After oral administration...

Claims

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Application Information

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IPC IPC(8): G01N21/64
Inventor 焦广旭焦东旭马月琴焦晨旭申文栋梁静王利超
Owner 焦广旭
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