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Ureteric branches support and preparation method thereof

A ureteral and biological technology, applied in stents, medical science, surgery, etc., can solve the problems of unfavorable biologically active factors and drug coating, and achieve the effect of reducing the coefficient of friction

Inactive Publication Date: 2009-05-06
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, degradable polymer ureteral stents are generally prepared by melt extrusion (Hou Yuchuan, Development of new biodegradable material ureteral stents, Jilin University, doctoral dissertation, May 2004) (Goldberg J R; Sinclair R G. Resorbable Ureteral stents made of biodegradable polymer, Patent Number(s): EP420541-A2; EP420541-A; AU9063643-A; CA2025626-A; JP3205059-A; US5085629-A; AU633361-B; It is not conducive to the coating of bioactive factors and drugs by materials

Method used

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  • Ureteric branches support and preparation method thereof
  • Ureteric branches support and preparation method thereof
  • Ureteric branches support and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, the preparation of polyε-caprolactone (PCL) ureteral stent

[0035]In this embodiment, the following three kinds of polyε-caprolactone (PCL) ureteral stents were prepared, and the specific preparation methods were as follows:

[0036] 1. First prepare 20ml, 2% (g / mL) PCL / THF solution (PCL is purchased from Aldrich, product number 440752), and then use a 1mm diameter tube coated with silicone oil (Beijing Chemical Reagent Company, product number 18142) Dip the glass rod into the PCL solution, let it dry slightly, and then dip it again. Repeat the above steps until the tube wall reaches 0.1mm. Finally, after THF was completely volatilized at room temperature, the tube was removed from the glass rod to obtain a PCL ureteral stent (see figure 2 ).

[0037] 2. First prepare 20ml of 15% (g / mL) PCL / THF solution (PCL is purchased from Aldrich, product number 440752), and then use a 1mm diameter tube coated with silicone oil (Beijing Chemical Reagent Company, pr...

Embodiment 2

[0039] Embodiment 2, containing developing agent BaSO 4 Preparation and application of polyε-caprolactone (PCL) ureteral stent

[0040] 1. Preparation of ureteral stent

[0041] Prepare the following three kinds of polyε-caprolactone (PCL) ureteral stents, the specific preparation method is as follows:

[0042] 1. First prepare 20ml, 2% (g / mL) PCL / THF solution (PCL is purchased from Aldrich, product number 440752), and add BaSO to the solution 4 Until the concentration is 5%, continue to stir and disperse, then use a glass rod with a diameter of 1mm coated with silicone oil (Beijing Chemical Reagent Company, product number 18142) to reversely dip the PCL solution, and then dip it after slightly drying, repeat the above step until the pipe wall reaches 0.1mm. Finally, after THF is completely volatilized at room temperature, the tube is removed from the glass rod to obtain a solution containing BaSO 4 PCL ureteral stent.

[0043] 2. First prepare 20ml of 10% (g / mL) PCL / THF ...

Embodiment 3

[0049] Example 3. Preparation of polylactic acid / glycolic acid copolymer (PLGA) ureteral stents with different hydrophilicity

[0050] In this embodiment, the following three kinds of polylactic acid / glycolic acid copolymer (PLGA) ureteral stents were prepared, and the specific preparation methods were as follows:

[0051] 1. First prepare 20ml, 2% (g / mL) PLGA / acetone solution (PLGA is purchased from Aldrich, product number 430471, LA:GA=85:15), and then use the surface coated with silicone oil (Beijing Chemical Reagent Company, product Dip a glass rod with a diameter of 1 mm (Product No. 18142) into the PLGA solution, let it dry slightly before dipping it, and repeat the above steps until the tube wall reaches 0.1 mm. Finally, after the THF was completely volatilized at room temperature, the tube was removed from the glass rod to obtain the PLGA ureteral stent.

[0052] 2. First prepare 20ml of 10% (g / mL) PLGA / acetone solution (PLGA is purchased from Aldrich, product number ...

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Abstract

The invention discloses a ureter bracket and a preparing method thereof; the ureter bracket uses biodegradable macromolecules as raw materials and is prepared through a dip forming method. In the method, a mould coated with parting medium on the surface is inserted into solution or meltwater of the biodegradable macromolecules for repeatedly dipping and film forming so as to get the ureter bracket. The degradable ureter bracket is characterized by various sizes, degradation rates and mechanical strengths, which can be compounded with various medicines or developers; furthermore, the ureter bracket can be applied in medical field and satisfy various requirements of clinical application. The method is characterized by simple operating process and mild operating conditions.

Description

technical field [0001] The invention relates to a ureteral support and a preparation method thereof. Background technique [0002] Ureteral stent is an essential equipment in clinical medicine, especially in urological surgery. The most widely used ureteral stent is the double J tube, and its material is mainly silicone resin and polyurethane modified polymer. Since the double J tube cannot be degraded, it needs to be taken out after implantation, which increases the pain of the patient's second operation and the work intensity of the physician. Ureteral stents made of biodegradable polymers can be degraded into small water-soluble molecules in the body after drainage and support functions are completed, which can be absorbed in the body or excreted with urine, avoiding the secondary surgery process. In addition, biodegradable polymer materials can be compounded with a variety of antibiotics, drugs, and biological regulators to prepare multifunctional composite ureteral st...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/14A61F2/82
Inventor 甘志华石旭东
Owner INST OF CHEM CHINESE ACAD OF SCI
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