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Anti-depression medicament using salvianolic acid B as raw material and production method thereof

A salvianolic acid and antidepressant technology, applied in the field of drugs for the treatment of depression, can solve problems such as side effects and patients calming down

Inactive Publication Date: 2009-03-04
张作光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs all have different degrees of side effects. Studies have shown that "the Fuan suppository contained in these drugs has an effect on balancing the body's functions, but more often than not, they still cannot calm the patient down.

Method used

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  • Anti-depression medicament using salvianolic acid B as raw material and production method thereof
  • Anti-depression medicament using salvianolic acid B as raw material and production method thereof
  • Anti-depression medicament using salvianolic acid B as raw material and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Referring to accompanying drawing 1, 10 kilograms of Salvia miltiorrhiza (conforming to the provisions of "The Pharmacopoeia of the People's Republic of China") were broken and soaked at normal temperature for 12 hours, extracted with water and precipitated with alcohol, concentrated and dried, and obtained 4.2 kilograms of Salvia miltiorrhiza extract (the yield of paste was 42%), and after High-efficiency liquid phase detection contains 0.168 kg of salvianolic acid B, the main functional component of the antidepressant of the present invention (the purity of salvianolic acid B in the salvia miltiorrhiza extract is 4%).

Embodiment 2

[0047] Referring to accompanying drawing 2, 10 kilograms of Salvia miltiorrhiza (conforming to the provisions of "The Pharmacopoeia of the People's Republic of China") were broken and soaked at normal temperature for 12 hours, extracted with water and precipitated with alcohol, separated by upper column chromatography, concentrated and dried, and obtained 0.8 kilograms of Salvia miltiorrhiza extract (extraction rate) 8%), 0.26 kilograms of salvianolic acid B (purity of salvianolic acid B in the salvia miltiorrhiza extract) containing post-receptor action mechanism antidepressant of the present invention is detected by high performance liquid phase.

experiment example 1 Embodiment 2

[0048] Experimental example 1 The impact of embodiment 2 on mouse tail suspension test

[0049] 1.1 Experimental animals

[0050] ICR mice, male, weighing 22.0±2g, grade II, were provided by the Department of Experimental Animal Science, Capital Medical University, Beijing.

[0051] 1.2 Experimental drugs

[0052] Example 2: Provided by Beijing Onal Biological Engineering Technology Co., Ltd.

[0053] Paroxetine (Seroxet): a product of China-US Tianjin SmithKline Pharmaceuticals Co., Ltd.

[0054] 1.3 Experimental Instrument: Stopwatch

[0055] 1.4 Dose Design

[0056] Example 2 Large dose: 160mg (containing salvianolic acid B 52.8mg) / kg / d, medium dose: 80mg (containing salvianolic acid B 26.4mg) / kg / d, small dose: 40mg (containing salvianolic acid B 13.2 mg) / kg / d.

[0057] 1.5 Experimental methods and results

[0058] 1.5.1 Group administration

[0059] Mice are divided into random groups, every group of 10: ① embodiment 2 high-dose group (160mg*kg -1, PO, administrat...

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Abstract

The invention discloses an antidepressant drug which takes salvianolic acid B as a raw material and the dose thereof. The invention further discloses a preparation method of the drug. Experiments prove that the drug can significantly reduce the immobility time of the tail suspension test and the forced swimming test of tested mice, thereby inferring that the drug has the effect of anti-experimental depression.

Description

technical field [0001] The invention relates to a medicine for treating depression made from salvianolic acid B, which can be used as medicine, nutrition and health food. [0002] The present invention also relates to the preparation method of the above-mentioned medicine for treating depression. Background technique [0003] Depression is a common illness. According to statistics, about 25% of women in the general population have experienced depression in their lifetime, and about 10% of men have experienced depression (Zhang Chunxing: "Modern Psychology"). Information provided by the World Health Organization: The incidence of depression in the world is about 11%. There are currently about 340 million mentally depressed patients in the world, and this number is still on the rise. The survey found that depression will increase in the next 20 years It is the second most common disease worldwide. [0004] At present, serotonin reuptake inhibitors (SSRIs) such as Prozac, Cy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61K9/14A61K9/20A61K9/48A61K36/537A61P25/24A23L1/30C07D307/80A23L33/10A23L33/105
Inventor 张作光
Owner 张作光
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