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Novel use of oxidation resistance dipeptide in fish extract polypeptide

An anti-oxidation and fish essence technology, applied in dipeptide ingredients, medical preparations containing active ingredients, cosmetics, etc., can solve the problems of unclear mechanism of action and unclear active ingredients, and achieve easy digestion and absorption, thermal stability. Good, high nutritional value effect

Active Publication Date: 2013-03-20
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for the peptides formed by enzymatic hydrolysis and their peptide products, most of them have unclear active ingredients and mechanism of action, including their specific biological functions, molecular weights of various polypeptide fragments after hydrolysis, and number of amino acid residues, etc.

Method used

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  • Novel use of oxidation resistance dipeptide in fish extract polypeptide
  • Novel use of oxidation resistance dipeptide in fish extract polypeptide
  • Novel use of oxidation resistance dipeptide in fish extract polypeptide

Examples

Experimental program
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Embodiment 1

[0022] The invention relates to a new application of the antioxidant dipeptide in the protamine polypeptide in the preparation of medicines, health products or cosmetics.

[0023] In fact, the present invention relates to the application of the antioxidant dipeptide in the protamine polypeptide in the preparation of anti-oxidative, anti-fatigue and immune-enhancing medicines.

[0024] Easy to absorb digestibility and nutritional function

[0025] Proteins undergo the action of various digestive enzymes in the small intestine to form hydrolyzed products including free amino acid (FAA) and a large number of oligopeptides (Oligopeptide, OP). The oligopeptide enters the brush border of the small intestine villi, and enters the blood circulation in the form of dipeptide and tripeptide (Small Peptide, SP) under the action of aminopeptidase and is utilized by the tissue. The study by Newey et al. confirmed the transport process of intact diglyceride, and proposed for the first time ...

Embodiment 2

[0052] The invention relates to the application of the antioxidant dipeptide in the protamine polypeptide in the preparation of a drug for treating or preventing sexual dysfunction.

[0053] By analyzing the amino acid sequences of various protamine polypeptides discovered so far, arginine generally accounts for more than two-thirds. This is a basic non-essential amino acid. It was first discovered by Kossel in 1896 from the hydrolyzate of protamine. of. The main physiological role of protamine polypeptides in the body is L-arginine, and arginine plays an important role in many organ systems of the human body.

[0054] In 1944, Holt and Albanesi confirmed that the lack of arginine is related to the impairment of testicular function. Arginine not only improves the occurrence of epididymal sperm, but also acts as an energy source for sperm motility in the form of phosphoarginine. Through the NMR study of arginine-stimulated glycolysis in goat epididymal sperm, Patel et al. expl...

Embodiment 3

[0064] The invention relates to the application of anti-oxidative dipeptide in protamine polypeptide in the preparation of anti-oxidation, anti-fatigue and immune-enhancing health food. The application mechanism is the same as that of Example 1.

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Abstract

The invention relates to a new use of an antioxidant dipeptide of a protamine hydrolyzate, the development of the new use of the antioxidant dipeptide in the prepration of antioxidant, anti-fatigue, immunity-enhancing drugs, health care productions or cosmetics, which is used for developing new products for being in line with the market demands, thereby fully utilizing the natural resources to benefit humankind. A series of antioxidant peptide components is searched by chromatographic separation methods including gel chromatography, ion-exchange chromatography and reversed-phase HPLC according to liquid chromatography tandem mass spectrometry and a NCBI database, and the peptides which have the highest anti-oxidant activity are identified as Pro-Arg and positioned at 1-2 and 16-17 residue parts in the sequence of protamine. The new synthetic dipeptide not only has strong activity for removing hydroxyl free radicals, but can also significantly reduce the production of intracellular oxygen free radicals, thereby protecting human diploid fibroblasts from being damaged by oxidation. The results provide theoretical basis for taking the protamine hydrolyzate as the raw material of drugs, health care foods and cosmetics and simultaneously provide scientific basis for widely utilizing the protamine.

Description

technical field [0001] The invention relates to the use of a protamine polypeptide component, in particular to a new use of the antioxidant dipeptide in the protamine polypeptide. Background technique [0002] Protamine, also known as protamine, is an alkaline protein mainly present in the mature sperm cells of fish (salmon, herring, trout). Its molecular weight is small, generally around 10KDa. It has been used as a natural preservative for food preservation and storage. At the same time, protamine is the only drug used to antagonize heparin in cardiopulmonary bypass cardiac surgery, and there are a lot of reports on its mechanism of action and adverse reactions during surgery. In addition, it was found that protamine has an inhibitory effect on the formation of tumor blood vessels, and affects the formation of blood vessels by preventing the movement of capillary endothelial cells; it can also inhibit the occurrence of vascular inflammation. [0003] The reactive oxygen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/05A61K8/64A61P15/08A61P37/02A61P39/06A61Q19/04A61Q19/08A61K38/16
Inventor 王勇刚韩福森吴巧玲王贺瑶朱锋荣
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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