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Cynanchum otophyllum schneid dispersible tablets and preparation method thereof

A technology of dispersible tablets and Qingyangshen, which is applied in the field of Qingyangshen dispersible tablets and its preparation, can solve the problems of low bioavailability, poor water solubility, and inability to meet clinical applications, and achieve high bioavailability, high dissolution rate, Improving the effect of treatment

Inactive Publication Date: 2009-02-04
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of total saponins of Qingyangshen is poor, and the bioavailability of ordinary tablets is low (after testing, the dissolution rate is about 40%), which cannot meet the needs of clinical application.

Method used

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  • Cynanchum otophyllum schneid dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Qingyangshen dispersible tablets were prepared according to the following prescription:

[0039] Qingyang ginseng total glycosides extract 10g

[0040] Disintegrant dry starch 4g

[0041] Disintegrant PVPP 4.5g

[0042] Lubricant magnesium stearate 1g

[0043] Surfactant SDS 1.4

[0044]

[0045] Makes 100 pieces

[0046] Take the prescription amount of total glucoside extract of Qingyang ginseng and pass through a 100-mesh sieve, disintegrants and lubricants pass through a 100-mesh sieve, and surfactants pass through a 80-mesh sieve, then grind and mix, then pass through an 80-mesh sieve, and directly compress into tablets, that is have to.

Embodiment 2

[0047] Example 2 Qingyangshen dispersible tablets were prepared according to the following prescription:

[0048] Qingyang ginseng total glycosides extract 12g

[0049] Disintegrant CMS-Na 4g

[0050] Disintegrant CCNa 2.5g

[0051] Lubricant talcum powder 1g

[0052] Surfactant SDS 1.4g

[0053]

[0054] Makes 100 pieces

[0055] Take the prescription amount of total glucoside extract of Qingyang ginseng and pass through a 100-mesh sieve, disintegrants and lubricants pass through a 100-mesh sieve, and surfactants pass through a 80-mesh sieve, then grind and mix, then pass through an 80-mesh sieve, and directly compress into tablets, that is have to.

Embodiment 3

[0056] Example 3 Qingyangshen dispersible tablets were prepared according to the following prescription:

[0057] Qingyang ginseng total glycosides extract 14g

[0058] Disintegrant CCNa 2g

[0059] Disintegrant PVPP 2.5g

[0060] Lubricant magnesium stearate 1g

[0061] Surfactant SDS 1.4g

[0062]

[0063] Makes 100 pieces

[0064] Take the prescription amount of total glucoside extract of Qingyangshen and pass through a 100-mesh sieve, disintegrants and lubricants pass through a 100-mesh sieve, and surfactants pass through a 80-mesh sieve, then grind and mix, then pass through an 80-mesh sieve, and directly compress into tablets to obtain .

[0065] Adopt HPLC method to measure the dissolution rate and content of Qingyangshengenin in the products of Examples 1~3 of the present invention, adopt visible light colorimetry to measure the content of Qingyangshengenin total glycosides, the result Qingyangshengenin dissolution rate, cont...

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PUM

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Abstract

The invention discloses a cynanchum otophyllum dispersible tablet and a preparation method thereof, relating to medicines. The cynanchum otophyllum dispersible tablet is made of the following raw materials by weight portions: 50-200 portions of an extract of cynanchum otophyllum total glucoside, 20-100 portions of an disintegrating agent, 1-10 portions of a lubricant and 1-20 portions of a surfactant, wherein, the disintegrating agent is CMS-Na, CCNa, PVPP, L-HPC and dry starch, the lubricant is magnesium stearate or talcum powder or superfine silica gel powder, the surfactant is SDS, sodium hexadecyl sulfate and sodium stearyl sulfate. The preparation method consists of the following steps: 20-200 portions of total glucoside of the cynanchum otophyllum by weight is taken out and sieved with a 100-mesh sieve; 20-100 portions of the disintegrating agent by weight and 1-10 portions of the lubricant by weight are taken out and respectively sieved with the 100-mesh sieve; 1-20 portions of the surfactant by weight is taken out and sieved with a 80-mesh sieve; then the sieved extract, the sieved disintegrating agent, the sieved lubricant and the sieved surfactant are ground and evenly mixed, and then the mixture is sieved with the 80-mesh sieve, and direct compression and sieving are carried out on the sieved mixture to obtain the dispersible tablet. The dispersible tablet has high dissolution and high bioavailability, can fully exert the drug action of the cynanchum otophyllum, and the preparation method is simple and feasible while suitable for industrialized production.

Description

technical field [0001] The invention relates to medicine, and relates to an application method of Qingyangshen total glycosides extracted from Qingyangshen, in particular to Qingyangshen dispersible tablets and a preparation method thereof. Background technique [0002] Qingyang ginseng is the tuber root of Cynanchum otophyllum Scheid, a plant of the Romoaceae family. Its main medicinal ingredient is qingyang ginseng saponin, which has the effects of calming the liver and tonifying the kidney, eliminating phlegm and relieving convulsions, and calming epilepsy; it is used for epilepsy, Dizziness, headache, vertigo, tinnitus, soreness of waist and knees, etc. [0003] At present, animal experiments have shown that total glycosides of Qingyang ginseng have anti-epileptic properties, and have obvious antagonism against audiogenic convulsions and ignition effects in rats, which proves that Qingyang ginseng has a very significant anti-epileptic effect; Yangshen has no antagonisti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61K9/20A61P25/08A61P25/04A61K125/00
Inventor 钱一鑫李魏林何珺卿晓红
Owner GUIZHOU UNIV
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