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Ordered porous magnetic hydroxylapatite material, preparation method thereof and applications

A hydroxyapatite and magnetic technology, applied in chemical instruments and methods, phosphorus compounds, medical science, etc., can solve the problems of uneven distribution of mesopore structure, uneven drug release, and non-porous structure, etc., and achieve a pore structure Orderly, good biocompatibility and bioactivity, easy to operate effect

Inactive Publication Date: 2009-01-07
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the uneven distribution of the pore structure in this system makes the drug release uneven and the drug effect is short, which limits the sustained release effect.
The international patent (1997, publication number: WO / 1997 / 001304) utilizes apatite and magnetic material to mix together to prepare magnetic hydroxyapatite with magnetic properties and good biocompatibility, which can be applied to the treatment of orthopedic diseases, but This material does not have a porous structure, has a small specific surface area, and has low surface activity, which inhibits its range of applications.

Method used

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  • Ordered porous magnetic hydroxylapatite material, preparation method thereof and applications
  • Ordered porous magnetic hydroxylapatite material, preparation method thereof and applications

Examples

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Embodiment 1

[0021] (1) Take monodisperse SiO with a particle size of about 500nm 2 Colloidal particles, dispersed in absolute ethanol, made into a 1wt% suspension, and SiO can be obtained after standing for 14 days 2 Ordered template; after mixing 11.753g of calcium nitrate tetrahydrate, 8.5ml of water, 3.4ml of trimethyl phosphate and 7ml of ethanol, the pH value of the system was adjusted to 9 with ammonia water, and then stirred at 80°C for 48 hours to obtain Hydroxyapatite sol, add the sol dropwise to SiO 2 In the ordered template, after drying at 50°C for 24 hours, it was calcined in a temperature-controlled furnace at 600°C for 2 hours, and finally soaked in 3.3mol / L sodium hydroxide solution for 3 days to prepare ordered porous hydroxyapatite material , The pore size distribution is around 400nm.

[0022] (2) Under the condition of argon protection, add 1.5g of ferric oxide into a 500ml three-necked bottle, add 100ml of deionized water, ultrasonically disperse for 20min, stir at ...

Embodiment 2

[0025] (1) Take monodisperse SiO with a particle size of about 500nm 2 Colloidal particles, dispersed in absolute ethanol, made into a 1wt% suspension, and SiO can be obtained after standing for 14 days 2 Ordered template; after mixing 11.753g of calcium nitrate tetrahydrate, 8.5ml of water, 3.4ml of trimethyl phosphate and 7ml of ethanol, the pH value of the system was adjusted to 9 with ammonia water, and then stirred at 80°C for 48 hours to obtain Hydroxyapatite sol, add the sol dropwise to SiO 2 In the ordered template, after drying at 50°C for 24 hours, it was calcined in a temperature-controlled furnace at 600°C for 2 hours, and finally soaked in 3.3mol / L sodium hydroxide solution for 3 days to prepare ordered porous hydroxyapatite material , The pore size distribution is around 400nm.

[0026](2) Under the condition of argon protection, add 1.5g of ferric oxide into a 500ml three-necked bottle, add 100ml of deionized water, ultrasonically disperse for 20min, stir at a...

Embodiment 3

[0029] (1) Take monodisperse SiO with a particle size of about 500nm 2 Colloidal particles, dispersed in absolute ethanol, made into a 0.5wt% suspension, and SiO can be obtained after standing for 14 days 2 Ordered template; after mixing 11.753g of calcium nitrate tetrahydrate, 8.5ml of water, 3.4ml of trimethyl phosphate and 7ml of ethanol, the pH value of the system was adjusted to 9 with ammonia water, and then stirred at 80°C for 48 hours to obtain Hydroxyapatite sol, add the sol dropwise to SiO 2 In the ordered template, after drying at 50°C for 24 hours, it was calcined in a temperature-controlled furnace at 600°C for 2 hours, and finally soaked in 3.3mol / L sodium hydroxide solution for 3 days to prepare ordered porous hydroxyapatite material , The pore size distribution is around 400nm.

[0030] (2) Under the condition of argon protection, add 1.5g of ferric oxide into a 500ml three-necked bottle, add 100ml of deionized water, ultrasonically disperse for 20min, stir a...

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Abstract

The invention relates to an orderly multi-aperture magnetic hydroxylapatite, the amplitude of the magnetic property of which can be controlled, and the saturation strength of which is between 0.1emu / g and 10emu / g. An orderly multi-aperture hydroxylapatite takes orderly arranged SiO2 as a die plate and is prepared by the steps of adding in drops the precursor of a hydroxylapatite, sintering, removing alkali liquor, etc. The prepared orderly multi-aperture hydroxylapatite is characterized in that apertures are distributed uniformly and the apertures are connected through micro-pores. Magnetic nano-particles are synthesized through the liquid phase method, the surfaces of the magnetic nano-particles are wrapped by SiO2 of different thicknesses, and the magnetic nano-particles have the core-shell structure characteristic. The orderly multi-aperture magnetic hydroxylapatite is formed by the static self-assembly and the wicking action of the magnetic nano-particles and the orderly multi-aperture hydroxylapatite, and the amplitude of the magnetic property can be adjusted by changing the proportion of the aperture size of the orderly multi-aperture hydroxylapatite and the grain size of the magnetic nano-particles. The orderly multi-aperture magnetic hydroxylapatite has the advantages of easily obtained materials, low cost, good magnetic property and biocompatibility of obtained materials, and application to the treatment of orthopedic disorders.

Description

technical field [0001] The invention belongs to the field of preparation of inorganic biological materials, and relates to hydroxyapatite and a preparation method thereof. Background technique [0002] Hydroxyapatite is an important component of bone tissue in organisms. It has good biocompatibility and osteoconductivity, and can promote the growth of new bone after implantation in the body. It is an ideal implant carrier material. Moreover, hydroxyapatite also has good adsorption properties, and has broad application prospects in biomedical fields such as blood purification, enzyme and protein separation. Three-dimensional ordered porous materials have excellent properties such as uniform pore size distribution, high porosity, large specific surface area, large adsorption capacity, and three-dimensional structure design. They have broad application prospects in the fields of biomedicine, adsorption, separation, and photocatalysis. Ordered porous hydroxyapatite combines the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/12
Inventor 王德平段祥黄文旵姚爱华周丽赟周萘
Owner TONGJI UNIV
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