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Complete-gastrodia tuber soft capsule and preparation method thereof

A technology of soft capsules and Gastrodia elata, which is applied in the field of Gastrodia elata preparations and its preparation. It can solve the problems of Gastrodia elata fine powder being difficult to dissolve and disperse, unable to be made into soft capsules, and uneven dispersion, so as to improve bioavailability and prevent disintegration time limit Prolonged, pronounced therapeutic effect

Active Publication Date: 2008-12-10
贵州益康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant found in practice that Gastrodia elata fine powder is not easy to dissolve and disperse in edible oil, and will aggregate into granules, and after being placed, it will be layered and dispersed unevenly, so it cannot be made into soft capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Gastrodia elata 1kg, polyethylene glycol 400 1.4kg, propylene glycol 200g

[0038] Take Gastrodia elata after drying and crush it into 120-mesh fine powder, then perform low-temperature intermittent sterilization for 3 times at 75-80°C for 12 hours each time, then add polyethylene glycol and propylene glycol, grind in a colloid mill for 10 minutes, mix well, spray The body temperature was set at 44°C, and 4000 soft capsules were sprayed and filled.

[0039] Usage and dosage: Take orally, 4 to 12 capsules at a time, 3 times a day.

Embodiment 2

[0040] Embodiment 2: Gastrodia elata 1kg, polyethylene glycol 400 1.7kg, propylene glycol 138g

[0041] Gastrodia elata was dried and crushed into 120-mesh fine powder, then subjected to low-temperature intermittent sterilization for 3 times at 75-80°C for 12 hours each time, then added polyethylene glycol and propylene glycol, mixed evenly, filled, and pressed into soft capsules 4000 grain.

[0042] Usage and dosage: Take orally, 4 to 12 capsules at a time, 3 times a day.

Embodiment 3

[0043] Embodiment 3: Gastrodia elata 1kg, polyethylene glycol 400 500g, propylene glycol 40g

[0044] Gastrodia elata was dried and crushed into 120-mesh fine powder, then subjected to low-temperature intermittent sterilization for 3 times at 75-80°C for 12 hours each time, then added polyethylene glycol and propylene glycol, mixed evenly, filled, and pressed into soft capsules 4000 grain.

[0045] Usage and dosage: Take orally, 4 to 12 capsules at a time, 3 times a day.

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PUM

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Abstract

The present invention provides a complete gastrodia tuber soft capsule and a preparation method thereof, which solves the defects of the prior art that the refined gastrodia tuber powder is hardly dissolved in edible oil, easily congregated into particles, delaminated and unevenly dispersed after placement. Calculated by weight portions, the present invention includes the following procedures: taking one portion of gastrodia tuber and grinding the gastrodia tuber into 120 meshes; adding 0.5 to 3 portions of polyglycol400 and propanediol accounting for 8% of the amount of polyglycol400 after sterilization; then evenly mixing, filling and pressing the mixture into soft capsules. Compared with the prior art, the present invention takes polyglycol400 as the diluting agent so that the refined gastrodia tuber powder can be better dispersed. In addition, the present invention has no delamination after placement and excellent stability and can better increase the biological utilization of the soft capsule preparation. The addition of propanediol into the diluting agent can prevent the soft capsule shell from hardening and the disintegration time limit from prolonging in storage. The complete gastrodia tuber soft capsule has obvious curative effect on headache and dizziness, numb limbs and tense tendons, hieronosus and hyperspasmia and other diseases.

Description

technical field [0001] The invention relates to a whole gastrodia elata preparation and a preparation method thereof, in particular to a whole gastrodia elata soft capsule preparation and a preparation method thereof. Background technique [0002] Gastrodia elata has relatively good curative effect on diseases such as headache, dizziness, limb numbness, but the effect of direct use is not ideal. In the prior art, Gastrodia elata is made into whole Gastrodia elata capsules or Gastrodia elata tablets, but they are only crushed into Gastrodia elata in the production process. The fine powder (fineness is 80-100 meshes), sterilized and filled into capsules or added with appropriate excipients and compressed into tablets. These drugs have relatively poor stability, are easy to absorb moisture, and have low bioavailability and poor effect. [0003] The original dosage form of Gastrodia elata is capsule, because capsule has above-mentioned problem, so the marketability of commodity...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/48A61K47/34A61P25/08A61P25/04A61P1/08A61K125/00A61K47/10
Inventor 张秋生高翔刘智
Owner 贵州益康制药有限公司
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