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Prescription medicine for curing senile dementia and preparation

A technology for Alzheimer's disease and drugs, which is applied in the direction of drug combination, drug delivery, and medical preparations containing active ingredients, etc., can solve problems such as adverse reactions and short-term effects, improve blood supply, inhibit the generation of oxygen free radicals, and improve Effects on cerebral blood flow

Inactive Publication Date: 2008-10-01
高海 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients often have significant differences in the response to a specific drug, and this difference in response is related to the following factors: the stage of AD onset, the degree of dementia, the degree of brain function damage, genetic factors (sporadic and familial) and the presence of individual factors. There are differences in response among patients, but there are also shortcomings such as short-term effects and certain adverse reactions.

Method used

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  • Prescription medicine for curing senile dementia and preparation
  • Prescription medicine for curing senile dementia and preparation
  • Prescription medicine for curing senile dementia and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Ginkgo biloba 600g Salvia 300g

[0055] The above medicinal materials are crushed into coarse powder, add 8 times of 70% ethanol, and extract twice at 60°C for 4 hours each time; ethanol is recovered from the extract under vacuum at 60°C, flocculated and precipitated with 5% chitosan, filtered, and the filtrate Pass through D101 macroporous resin, elute with water first, and then elute with 75% ethanol; the alcohol eluent is vacuum-recovered at 60° C. ~60°C) extraction for 3 times, the alcohol-water solution was concentrated under vacuum at 60°C, freeze-dried, and the obtained extract was added with 5g of microcrystalline cellulose, 5g of sodium carboxymethyl starch, 15g of lactose, and 1g of cyclamate, mixed well, and granulated , dried at low temperature, added an appropriate amount of magnesium stearate, compressed into 100 tablets, each 0.4g.

Embodiment 2

[0057] Ginkgo biloba 600g Salvia 300g

[0058] The above medicinal materials were crushed into coarse powder, added 8 times of 70% acetone, extracted twice at 50°C for 4 hours each time; acetone was recovered from the extract under vacuum at 50°C, flocculated and precipitated with 5% chitosan, filtered, and the filtrate Pass through the AB-8 macroporous resin, elute with water first, then elute with 80% ethanol; the alcohol eluent is vacuum-recovered at 60°C under reduced pressure until the alcohol concentration is 20%, adjust the pH value to 3, and use an equal volume of petroleum ether (30-60°C) extraction for 3 times, the alcohol-water solution was concentrated under reduced pressure at 60°C, freeze-dried, added 10g of mannitol to the obtained extract, dissolved in an appropriate amount of water for injection, adjusted the pH value to 6, added water for injection to 200ml, filtered Pass until clear, subpackage at 2ml / to, and freeze-dry to obtain.

Embodiment 3

[0060] Ginkgo biloba 600g Salvia 300g

[0061] The above medicinal materials are crushed into coarse powder, add 8 times of 60% acetone, and extract twice at 60°C for 4 hours each time; ethanol is recovered from the extract under vacuum at 60°C, flocculated and precipitated with 5% chitosan, filtered, and the filtrate Pass through the AB-8 macroporous resin, elute with water first, then elute with 75% ethanol; the alcohol eluent is vacuum-recovered at 60°C under reduced pressure until the alcohol concentration is 20%, adjust the pH value to 3, and use an equal volume of petroleum ether (30-60°C) extraction for 3 times, the alcohol-water solution was concentrated under reduced pressure at 60°C, the obtained extract was added with 130g of mannitol, dissolved in an appropriate amount of water for injection, the pH value was adjusted to 6, filtered until clear, and directly frozen to become freeze-dried Tablets, 0.3g each.

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Abstract

The invention relates to a composition medicine used for curing senile dementia and a preparation method thereof, which uses ginkgo leaves and salvia miltiorrhiza as raw materials. The raw materials are processed by soaking for extraction at low temperature, refining of column absorption, cooling and drying for obtaining extracts; then appropriate amount of pharmaceutic adjuvant are added for preparing pharmaceutical preparations of formulations allowed by various pharmaceutics by the common technique. The invention has explicit pharmic composition, advanced technique and definite curative effects; the medicine prepared by the invention and used as the medicine for providing nutrition to protect cranial nerves and preventing degenerative brain aging has obvious effects; the effects of the medicine are obviously stronger than using the ginkgo leaves or the salvia miltiorrrhiza alone; the compatible medication has addition and synergetic effect; the medicine has excellent effects on curing the senile dementia, learning and memory dysfunction and the brain aging, etc.

Description

technical field [0001] The content of the invention belongs to the technical field of application and preparation of pharmaceuticals, and relates to a prescription medicine for treating senile dementia and a preparation method thereof. Background technique [0002] Alzheimer's disease refers to a disease caused by chronic progressive intellectual impairment, diffuse atrophy and degenerative changes of brain tissue in the elderly, and is characterized by Alzheimer's disease (AD) and vascular dementia (Vascular dementia). Dementia, VD for short) is the most common, its main clinical manifestations are progressive memory and cognitive impairment, and the early symptoms of patients are mostly memory loss, which gradually develops from amnesia of recent events to memory loss of both recent and distant events. symptom. According to relevant researches, Alzheimer's disease is related to the dysfunction of various transmitters and modulators such as cholinergic, monoaminergic, neur...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 高海郭书台张志鹏杨学礼
Owner 高海
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