Weight bearing tissue engineering bone porous pure magnesium bracket and bracket imitation human bone material surface coatings

Abstract

A weight bearing tissue engineering bone porous pure magnesium stent and a surface coating of human bone simulating material of the stent are provided. The stent is made from high pure magnesium powder and pore former into cylinders or round plates with certain diameter (D) and height (H) through powder metallurgy and main holes (1), interlocking pores (2) and blind holes (3) are randomly distributed. The main holes are mutually communicated. The blind holes are enclosed. The total volume of all holes and pores occupies 35-55 percent of the outer contour volume of the stent. The volume of the blind holes occupies 2-5 percent in all holes and pores. The diameter of the main holes and the blind holes is 200-500Mum, and the diameter of communicating holes is 50-100Mum. The formation of the surface coating of the human bone simulating material of the stent (4) is that the stent is immersed in the coating solution with a constant temperature of 37 DEG C, and the coating solution contains Na<+>, K<+>, Ca<2+>, Mg<2+>, HCO3-, Cl<->, HPO4<2->, SO4<2-> and Type I collagen. Finally, the coating of the stent is formed into hydroxyapatite containing magnesium ions and the Type I collagen, and the thickness is 1-3Mum.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering materials, in particular to a porous pure magnesium bracket for load-bearing tissue engineering bone and a surface coating of the bracket imitating human bone material. Background technique [0002] In the bone tissue engineering of modern medicine, seed cells, biomaterials and tissue construction are the three most basic elements, and biomaterials or scaffold materials are one of the most critical factors affecting bone tissue construction, which must have good biocompatibility , degradability, low immunogenicity and certain spatial structure, porosity, degradation rate and other characteristics. [0003] According to different bone defect sites, different material scaffolds made of natural coral, tricalcium phosphate β-TCP and partially decalcified bone pDBM were selected, and the skull defects of sheep and dogs, the alveolar ridge bone defects of dogs and the mandible were succes...

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problems that pDBM / hBMSC and other complexes lack certain mechanical strength in the early stage of clinical trials, and cannot be applied to bone defects in weight-bearing parts of limbs, etc., the present invention designs a porous pure magnesium scaffold for weight-bearing tissue engineering bone and a surface coating of the scaffold imitating human bone material , can be applied to bone defects in the weight-bearing parts of human limbs, such as femur, tibia, fibula and other long bones, and make the mechanical properties of porous pure magnesium scaffolds more similar to those of human bones

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