Dipyridamole orally disintegrating tablet and preparation

Abstract

The invention relates to dipyradimole orally disintegrating tablet and a preparation method thereof, which pertains to a pharmaceutic preparation field. Components and mass percentages thereof of the orally disintegrating tablet are: 5-50 percent of dipyradimole, 20-70 percent of stuffing agent, 10-40 percent of disintegrating agent, 1-5 percent of effervescent, 0-3 percent of correctant, 0.5-1.8 percent of lubricant and 8-20 percent of adhesive. The method of the invention comprises the following steps: 1) the stuffing agent, the disintegrating agent, the correctant and the effervescent are respectively ground for 30-60min and then fully blended into a mixture; 2) the dipyradimole is ground and added in the mixture cumulatively; after fully blended, the mixture passes through a 100 mesh sieve for 2-3 times; 3) the mixture is made into soft material by the adhesive; then the soft material is pelletized through a 16 mesh sieve and forced-air dried for 4-6 hours at the temperature ranging from 40-50 DEG C; the pelletized granules are sifted by a 20 mesh sieve; the lubricant is added in the pelletized granules and fully blended to prepare the dipyradimole orally disintegrating tablet after stamping and slice production. The orally disintegrating tablet of the invention has the advantages of short disintegrating time, rapid effect and convenient using, etc.

Description

technical field [0001] The invention relates to a dipyridamole medicament, in particular to a dipyridamole orally disintegrating tablet dosage form and a preparation method thereof. Background technique [0002] Oral tablet delivery is a matter of concern as the average human lifespan increases and swallowing ability declines with age. It is estimated that about 50% of the population has difficulty swallowing tablets and capsules, affecting compliance with drug therapy. In the field of pediatrics and geriatrics, there is a great demand for solid dosage forms that can be dissolved or suspended in water, chewable or rapidly dissolved in the mouth. can solve this problem. This dosage form can quickly disperse or dissolve in saliva after being put into the mouth, and the drug can be absorbed through the mucous membrane in the oral cavity or esophagus. The bioavailability is higher than that of ordinary preparations, and the side effects caused by first-pass metabolism can also...

AI Technical Summary

Problems solved by technology

[0005] At present, the preparations of dipyridamole mainly include injections, sustained-release tablets, ordinary tablets, etc., while the curative effect of injections can be confirmed, there are disadvantages of inconvenient medication for patients.

Dipyridamole tablets have problems such as slow absorption and low bioavailability, which affect the curative effect. In many cases, quick-acting drugs are needed in clinical use. At present, there is no immediate-release oral preparation of dipyridamole.