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Ionic liquid as well as preparation method and its use in biological transesterification synthesis

An ionic liquid and anion technology, applied in fermentation, organic chemistry, etc., can solve the problems of restricting practical application, decreased enzyme activity, unfavorable, etc., and achieve the effect of increasing half-life, increasing yield, and high yield

Inactive Publication Date: 2008-07-23
JIANGNAN UNIV +1
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Problems solved by technology

Due to the characteristics of high polarity and relatively large solubility in water, this kind of ionic liquid is extremely unfavorable to enzyme-catalyzed reactions, often leading to a significant decrease in enzyme activity, which greatly restricts its use in biocatalysis. practical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] 1. Preparation of Ionic Liquids

[0027] (1) Add 1 mole of 1-methylimidazole and 1 mole of bromoisobutane into a three-necked flask equipped with a stirrer, reflux condenser, and thermometer, turn on the electric stirrer, slowly raise the temperature to 60°C and keep it warm for reaction 18h, then slowly raise the temperature to 85°C to continue the reaction until the reaction system turns into a viscous transparent liquid again, collect the viscous liquid in the lower layer to obtain light yellow 1-isobutyl-3-methylimidazolium bromide .

[0028] (2) Transfer the intermediate product 1-isobutyl-3-methylimidazolium bromide obtained in (1) to a beaker, add 1000ml of deionized water, turn on the electric stirrer, and add 1 mole of KPF in batches 6 or LiN(CF 3 ) 2 , Stir at room temperature for more than 4h, discard the upper aqueous phase, and wash the ionic liquid with water until bromide ions cannot be detected (use silver nitrate to check bromide ions).

[0029] 2. ...

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Abstract

The invention discloses an ionic liquid with 1-isobutyl-3-methylimidazole structure and the preparation method and the application among biological transesterification reaction, belonging to technical field of organic compound preparation and application. The preparation method is characterized in that: equimolar methylimidazole and bromination isobutene are mixed directly and reacted for 18 hours at the temperature of 60 DEG C before heated slowly to 85 DEG C for continuous reaction until the reaction system is changed into sticky transparent liquid; double decomposition reaction is made for 1-isobutyl-3-methylimidazole bromide salt and equimolar inorganic salt containing different anions to get each kind of ion liquid crude product (the anion comprises PF6[-] and N(CF3)2)[-]. When the ion liquid crude product cannot be detected by bromine ion using super-pure water washing, acetone with five times of volume is used for dilution (the viscosity is close to water); active carbon and silica gel are respectively adopted for decoloration before vacuum distillation is made to remove acetone and non-reactant, thereby getting colorless products. The the preparation method for ionic liquid with 1-isobutyl-3-methylimidazole structure has the advantages of simple preparation technique, environmental protection, low cost, high purity for the ion, and thus can be applied in spectrum study and biocatalysis reaction.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of organic compounds, and particularly relates to a good solvent that can be used as a biotransesterification reaction. Background technique [0002] The main feature of green chemistry is atom economy, that is, designing the synthesis procedure so that the materials used in the reaction process can enter the final product as much as possible. Green chemistry requires that the synthetic method adopted has high conversion rate and excellent selectivity. As a green solvent, ionic liquids are often used in some chemical reactions such as enzyme catalysis, organic synthesis, chemical separation, and electrochemistry. Ionic liquids refer to salts composed of organic cations and inorganic or organic anions that are liquid at room temperature or near room temperature. Compared with traditional organic solvents, ionic liquids have invisible vapor pressure, are not easy to emit, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/58C12P7/62
Inventor 李在均黄亚茹方银军单海霞任国晓
Owner JIANGNAN UNIV
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