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Duck plague vaccines and special strains therefor

A duck plague virus, duck plague technology, applied in the field of duck plague vaccine and its special strains, can solve the problems of immunization failure, immunization failure, improper storage and transportation, etc. Effect

Inactive Publication Date: 2008-06-18
CHINA INST OF VETERINARY DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing duck plague attenuated live vaccine, in the use process, has the possibility of immune failure due to improper storage and transportation (Yang Daijian et al. Immunization failure and the occurrence of duck plague [J]. China Poultry, 1998, 20 (11) :20-21)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, utilize the duck embryo adaptation virus of duck plague herpes virus AV1221 strain to prepare duck plague vaccine

[0024] 1. Establishment of Seed Batches for the Production of Duck Plague Herpes Virus AV1221 Strain

[0025] The duck embryo-adapted virus of duck plague herpes virus AV1221 strain was established through duck embryo passage. Through the comparison of the immunogenicity and virulence of the three strains of DPV, the DE2 generation duck embryo virus of the duck plague herpes virus AV1221 strain was selected as the seed virus for seedling production, and the duck plague virus NJ strain D 5 Substitute duck liver tissue poison is used as a strong poison for testing. DE of AV1221 strain using duck embryos 2 Viruses were continuously passaged for 6 times. The identification results of the DE2-DE7 freeze-dried seed virus showed that no bacteria, mold, mycoplasma and foreign virus contamination were found; the virus content was 10 per 0.2mL 4.38...

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PUM

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Abstract

The present invention discloses a duck plague vaccine and a special virus strain. The active component of the duck plague vaccine is inactivated duck plague bleb virus AV1221 strain duck embryo adapted virus. The duck plague vaccine of the present invention is made from inactivated virus, which has good safety and is convenient for storing, transporting (2 DEG C to 8 DEG C) and using, and the immunity effect is stable.

Description

technical field [0001] The invention relates to a duck plague vaccine and its special strain. Background technique [0002] Duck plague (Duck Plague), also known as duck viral enteritis, is an acute, contact, and septic infectious disease that harms ducks, geese, and other Anseriformes. Lesions and parenchymal organ degenerative changes are the main features. Ducks of any breed, age and sex can be infected, but the incidence of adult ducks is higher than that of young ducks, and the mortality rate of laying hens is the highest (Yin Zhen, Liu Jinghua. Animal Virology [M]. Second Edition. Beijing: Science Press, 1997: 1073-1077). The disease was first reported in Holland by Baudet (Baudet A E R F. mortality in ducks in the Netherlands caused by a filterable virus. Fowl plague [J]. Tijdschr Diergeneeskd, 1923, 50: 455-459.), Huang Yinxian et al. Shou Shu. The study of duck plague [J]. Journal of South China Agricultural University, 1959, 1 (1): 67-78) first discovered the exi...

Claims

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Application Information

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IPC IPC(8): C12N7/00C12N7/04A61K39/255A61P31/22
CPCY02A50/30
Inventor 范书才李虹史大庆朱良全康凯
Owner CHINA INST OF VETERINARY DRUG CONTROL
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