Lactase orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses oral cavity disintegration tablets of anti lactose intolerance and lactase deficiency and a preparation method thereof. The formula of the invention comprises active component lactase, excipient diluent, sweet excipient, disintegrant, adhesive, wetting agent, glidants and lubricant. The diluent can use one or a plurality of mannitol, sorbitol, xylitol and erythrose; the sweet excipient can employ one or a plurality of fructoses, mannitol, xylitol, sucrose, aspartame and flavor; the disintegrant can adopt one or a plurality of sodium carboxymethyl starch, crosslinking carboxymethyl cellulose natrium, crosslinking povidone, low-substituted hydroxypropyl cellulose, microcrystalline cellulose and pre gelatinized starch; the adhesive can employ one from povidone, starch slurry and various cellulose types; the glidants can adopt micropowder silica gel or talcum powder; the lubricant can employ one from magnesium stearate, calcium stearate, stearic acid, hydrogenation vegetable oil and polyethylene glycol; the wetting agent can be selected one from ethanol, water and aqueous ethanol solution.

Description

technical field [0001] The invention relates to a lactase orally disintegrating tablet and a preparation method thereof. Background technique [0002] Lactose is the main carbohydrate in milk, accounting for about 4.4% of milk (about 7.2% in human milk). Lactose is a disaccharide in which D-glucose (Glucose) and D-galactose (Galactose) are bonded by β-1,4. Lactose only exists in the milk of mammals, and is the most important energy source for human infants, but not all mammals contain lactose (for example, the milk of sea animals such as whales and seals does not contain lactose. lactose). Lactose has the following three physical characteristics: 1. Poor solubility: This is the main problem when dairy products are processed. 2. Low sweetness: the sweetness of α-state lactose is only 16-18 of the sweetness of sucrose (calculated as 100 of sucrose). 3. Indigestibility: The absorption efficiency of lactose is only 1 / 32 of that of glucose. [0003] Lactose has the effect of...

AI Technical Summary

Problems solved by technology

Lactose has the following three physical characteristics: 1. Poor solubility: This is the main problem in dairy product processing

2. Low sweetness: the sweetness of α-state lactose is only 16-18 of the sweetness of sucrose (converted with sucrose as 100)

3. Indigestible: the absorption efficiency of lactose is only 1 / 32 of that of glucose

[0007] With the improvement of my country's economic level and living standards, people's intake of milk is increasing. However, due to the lack of lactase in the epithelial cells of the small intestine, many people cannot decompose and absorb lactose after drinking milk. After lactose enters the colon, it is absorbed by intestinal bacteria. Decomposition produces a large amount of short-chain fatty acids such as lactic acid and formic acid and hydrogen gas, which increases the osmotic pressure and increases the water in the intestinal cavity, causing abdominal distension, bowel sounds, intestinal colic, and even diarrhea, which undoubtedly limits people's appreciation of milk. intake