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Method for preparing scutellaria dispensing granule

The technology of formula granules and scutellaria baicalensis is applied in the field of preparation of scutellaria baicalensis granules, can solve problems such as no literature report on the preparation process of scutellaria baicalensis granules, and achieve the effects of no loss of medicinal components, poor water solubility and obvious curative effect.

Inactive Publication Date: 2008-04-30
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the traditional Chinese medicine decoction is used in the preparation of Scutellaria baicalensis, and there is no literature report on the preparation process of Scutellaria baicalensis formula granules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 5000g of Scutellaria baicalensis slices, add 10 times the amount of water in the first decoction, add 1.5% CaO in the mass of Scutellaria baicalensis pieces, stir well, heat to boiling, put in the decoction pieces of Scutellaria baicalensis, decoct for 1.5 hours, add 8 times the amount of water in the second decoction, and decoct Boil for 1.5 hours, combine the second decoction, and filter; the filtrate is concentrated under reduced pressure at a vacuum of 0.08Mpa to a clear paste with a relative density of 1.10 (55°C); spray drying, the inlet air temperature of the spray dryer is 172°C, and the air outlet Temperature 86°C, make 862g of dry extract powder, add 132g of maltodextrin, add 6g of magnesium stearate, mix well; dry granulation, the main pressure of the roll of the dry granulation mill is 23kg / cm 2 , roll side pressure 16kg / cm 2 , roll speed 18r / min, feeding speed 128r / min, granulate, sieve, make 1000g of granule of 18-40 mesh, sub-package, obtain the fini...

Embodiment 2

[0016] Take 5000g of Scutellaria baicalensis slices, add water with 12 times the mass of Scutellaria baicalensis slices for the first decoction, add 1.5% CaO of the mass of Scutellaria baicalensis slices, stir well, heat to boiling, add Scutellaria baicalensis slices, decoct for 2 hours, add 9 times the amount of water for the second decoction, and decoct After 1.5 hours, the second decoction was combined and filtered; the filtrate was concentrated under reduced pressure at a vacuum of 0.09Mpa to a clear paste with a relative density of 1.12 (55°C); spray drying, the inlet air temperature of the spray dryer was 175°C, and the outlet air temperature 88°C, make 850g of dry extract powder, add 145g of maltodextrin, add 5g of magnesium stearate, and mix well; dry granulation, the main pressure of the roll of the dry granulation rolling mill is 23kg / cm 2 , roll side pressure 17kg / cm 2 , roll speed 17r / min, feeding speed 133r / min, granulate, sieve, make 1000g of 18-40 mesh granule, ...

Embodiment 3

[0018] Take 5000g of Scutellaria baicalensis, add 10 times the amount of water in the first decoction, add 1.5% CaO in the mass of Scutellaria baicalensis, stir well, heat to boiling, add Scutellaria baicalensis, decoct for 2 hours, add 7 times the amount of water in the second decoction, and decoct Boil for 1.5 hours, combine the decoction, and filter; the filtrate is concentrated under reduced pressure at a vacuum of 0.08Mpa to a clear paste with a relative density of 1.11 (55°C); spray drying, the inlet air temperature of the spray dryer is 172°C, and the outlet air temperature is 86°C. ℃, make 872g of dry extract powder, add 122g of maltodextrin, add 6g of magnesium stearate, and mix well; dry granulation, the main pressure of the roll of the dry granulation rolling mill is 24kg / cm 2 , roll side pressure 18kg / cm 2 , roll speed 18r / min, feeding speed 135r / min, granulate, sieve, make 1000g of granule of 18-40 mesh, sub-package, obtain the finished product of Scutellaria baic...

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Abstract

The invention relates to a process for preparation of dispensing granules of scutellaria root, belonging to the technical field of preparation of traditional Chinese medicine dispensing granules. The process for preparation comprises the following procedures: for the first decoction, 8-12 times of decoction pieces of scutellaria root water and 1-2.5% of quality of decoction pieces of scutellaria CaO are charged, stirred evenly and heated to boiling state and then decocting pieces of scutellaria root is charged and decocted for 1-3 hours. For the second decoction, 6-10 times of decoction pieces of scutellaria root water is charged and decocted 0.5-2.5 hours. The decocting liquid of two decoctions is mixed and filtered, and the filtered liquid is depressed and concentrated into clear paste with 1.08-1.14 relative density under evacuation of 0.06-0.09 MPa and temperature of 50-60 DEG C. The clear paste is spray-dried and prepared into dry extract. Auxiliary material is charged according to mass ratio of decoction pieces of scutellaria root and dextrin or lactose or maltodextrin 100:1.2-3.8 and magnesium stearic acid is charged according to mass ratio of decoction pieces of scutellaria root and magnesium stearic acid 100:0.05-0.15 and mixed evenly. Granules with 18-40 mesh sieves are prepared by dry granulating method and integrated, and then disppensing granules of scutellaria root are obtained. The process for preparation has simple procedures and reasonable process and the medical effective components can not be damaged, thereby the content of baicalin in the obtained dispensing granules scutellaria root is no less than 150mg / g.

Description

technical field [0001] The invention relates to a method for preparing scutellaria baicalensis formula granules, which belongs to the technical field of preparing traditional Chinese medicine formula granules. Background technique [0002] Scutellaria baicalensis is a commonly used traditional Chinese medicine, which has the effects of clearing away heat and dampness, purging fire and detoxification, stopping bleeding and preventing miscarriage. It is used for chest tightness and nausea due to damp-warm and summer-heat, fullness due to damp-heat, dysentery, jaundice, cough due to lung-heat, high fever and polydipsia, vomiting of blood-heat, carbuncle and sore, restless fetal movement, etc. Scutellaria baicalensis has a wide range of clinical applications, and is often used to treat upper respiratory tract infections, urinary system infections, bacillary dysentery, hepatitis, and high blood pressure. Scutellaria baicalensis mainly contains flavonoids such as baicalin, wogoni...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/16A61P1/12A61P1/16A61P9/12A61P11/00A61P13/00A61P31/04A61P31/12A61K125/00
Inventor 周嘉林徐以亮李松王元清
Owner JIANGYIN TIANJIANG PHARMA
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