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Method of treating skin ulcers using oxidative reductive potential water solution

A technology of aqueous solution and saline solution, which is applied in the direction of active ingredients of peroxides, drug combinations, skin diseases, etc., and can solve problems such as not being able to produce enough ORP water

Active Publication Date: 2013-01-30
OCULUS INNOVATIVE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, existing production techniques do not produce sufficient commercial-scale quantities of ORP water to permit its widespread use as a disinfectant in healthcare settings

Method used

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  • Method of treating skin ulcers using oxidative reductive potential water solution
  • Method of treating skin ulcers using oxidative reductive potential water solution
  • Method of treating skin ulcers using oxidative reductive potential water solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0203] These examples demonstrate the unique characteristics of the ORP water solution of the present invention. The ORP water solution samples of Examples 1-3 were analyzed according to the methods described herein to determine the physical properties and levels of ionic species and other chemical species present in each sample. The results obtained for chlorine dioxide, ozone, and hydrogen peroxide are based on the standard test methods used to determine these species; however, the results may indicate a different species that may also produce a positive test result. Furthermore, it has been reported that chlorine dioxide, ozone, and hydrogen peroxide can react with hypochlorite, causing their consumption as well as other species such as HCl and O 2 ) generation. Table 1 shows the pH, oxidation-reduction potential (ORP) and ionic species present for each ORP water solution sample.

[0204] Table 1: Physical characteristics and ion species contained in ORP water solution sa...

Embodiment 4-10

[0208] These examples demonstrate the addition of varying amounts of bleach to the ORP water solution of the present invention. In particular, these examples demonstrate the antimicrobial activity and fabric bleaching capabilities of the compositions.

[0209] Prepare 10% Clorox with distilled water bleach solution. The following solutions were then prepared with 10% bleach solution: 80% ORP water solution / 20% bleach (Example 4); 60% ORP water solution / 40% bleach (Example 5); 40% ORP water solution / 60% bleach 20% ORP water solution / 80% bleach (Example 7); and 0% ORP water solution / 100% bleach (Example 8). Two control solutions were also used for comparison, including 100% ORP water solution / 0% bleach (Example 9) and ORP water solution with 0.01% Tween 20 detergent (Example 10). The physical characteristics of these samples were determined, especially pH, oxidation-reduction potential (ORP), total chlorine (Cl - ) content, hypochlorous acid (HClO - ) content, chlorine diox...

Embodiment 11

[0222] This example relates to the toxicological characteristics of the ORP water solution of the present invention. Microcyn 60 (or M60) - an exemplary ORP water solution of the present invention - was used in these studies.

[0223] In terms of safety, M60 has no irritation to the skin or conjunctiva of rabbits as tested according to international standards (AAMI 1997, NV SOP 16G-44, PFEUM 2000). In addition, acute inhalation toxicity studies in rats confirmed the safety of Microcyn 60 administered by this route.

[0224] The irritation potential of Microcyn 60 was evaluated in a primary eye irritation study in rabbits. Microcyn 60 in a volume of 0.1 mL was instilled into the right eyes of 3 New Zealand white rabbits. The left eye of each animal was left untreated as a control. Eyes were observed and scored for corneal ulceration or opacity, iris inflammation, conjunctival redness, or conjunctival edema at 1, 24, 48, and 72 hours. All animals were also observed once dail...

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Abstract

A method of treating burns, preferably second and third degree burns, by administration of an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours is provided.

Description

[0001] Cross-references to related patent applications [0002] This patent application claims priority to the following U.S. provisional patent applications: 60 / 760,635 filed January 20, 2006, 60 / 760,567 filed January 20, 2006, 60 / 760,645 filed January 20, 2006 60 / 760,557 filed on January 20, 2005, 60 / 730,743 on October 27, 2005, 60 / 676,883 on May 2, 2005, 60 / 667,101 on March 31, 2005, and 2005 60 / 664,361, filed March 23, which is hereby incorporated by reference into this application in its entirety. field of invention [0003] The present invention relates to a method of treating burns, preferably 2nd and 3rd degree burns, by administering an aqueous redox potential solution. Background of the invention [0004] Oxidation-reduction potential (ORP) water (also known as super-oxidized water) can be used as a non-toxic disinfectant for cleaning in a variety of situations to destroy microorganisms including bacteria, viruses and spores. For example, ORP water can be used in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/40A61P17/02
Inventor H·阿里米
Owner OCULUS INNOVATIVE SCI
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