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Injection containing huperzine for sulci venosi and method of preparing the same

A technology for intravenous injection and huperzine A, which is applied in the field of medicine and can solve problems such as restricting the use of medicines

Inactive Publication Date: 2008-02-27
ZHEJIANG WANBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Our study also found that huperzine A can be clinically combined with drugs that promote the recovery of cholinergic nerve function (rivastigmine bitartrate, ginkgolide A, trihexyphenidyl, levodopa, carbidopa, etc.) Or traditional Chinese medicine extracts for promoting blood circulation and removing blood stasis (Salvia miltiorrhiza extract, safflower extract, Ginkgo biloba extract, Erigeron breviscapitalis extract and Panax notoginseng extract, etc.) Weak effect, and the huperzine A injection currently on the market only has intramuscular administration and no intravenous drip administration, which greatly limits the clinical use of this drug. After a lot of research, we have applied solvent dispersion salt formation technology Finally, the intravenous huperzine A injection was successfully developed, which provided great convenience for elderly patients and greatly improved the compliance of medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] prescription:

[0016] Huperzine A 100mg

[0017] Proper amount of dilute hydrochloric acid

[0018] Appropriate amount of water for injection

[0019] Makes 1000ml

[0020] Preparation method: Dissolve huperzine A in dilute hydrochloric acid and ethanol and fully dissolve it to become huperzine A dispersed ethanol solution, add water for injection to the full amount, stir well until uniform, add appropriate amount of activated carbon, stir evenly, filter until clear, Potting, sterilizing at 100°C for 30 minutes, and passing the inspection, it is Huperzine A Injection.

Embodiment 2

[0022] prescription:

[0023] Huperzine A 200mg

[0024] Proper amount of dilute hydrochloric acid

[0025] Ethanol 10ml

[0026] Mannitol 50g

[0027] Makes 1000ml

[0028] Preparation method: Dissolve huperzine A in an appropriate amount of dilute hydrochloric acid and ethanol and fully dissolve it to become a dispersed ethanol solution of huperzine A, add a sufficient amount of ethanol, add an appropriate amount of activated carbon, stir evenly, filter until clear, aseptically fill, and store Freeze-dry in a freeze dryer, press the cap, and pass the inspection, which is Huperzine A for injection.

Embodiment 3

[0030] prescription:

[0031] Huperzine A 50mg

[0032] Proper amount of dilute hydrochloric acid

[0033] Ethanol 1ml

[0034] Sodium chloride 450g

[0035] Appropriate amount of water for injection

[0036] Make 1000 bags

[0037] Preparation method: Dissolve huperzine A in appropriate amount of dilute hydrochloric acid and fully dissolve in ethanol to become huperzine A dispersed ethanol solution, add it to the dissolved sodium chloride solution, stir evenly, add appropriate amount of activated carbon, stir evenly, filter Until clarification, filling, sterilizing at 121°C for 30 minutes, and passing the inspection, Huperzine A injection is obtained, wherein 50ml / bag.

[0038] Four, embodiment 4

[0039] prescription:

[0040] Huperzine A 1g

[0041] Proper amount of dilute hydrochloric acid

[0042] Sodium chloride 450g

[0043] Glycerin 10ml

[0044] Make 1000 bags

[0045] Preparation method: Dissolve huperzine A in an appropriate amount of dilute hydrochloric...

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PUM

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Abstract

The invention provides intravenous injections of Huperzine and process for preparation, which include the dose forms of injections, fluid infusions and freeze dried injections.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a drug preparation for intravenous injection and a preparation method thereof, in particular to an injection, an infusion solution, a freeze-dried powder injection composed of huperzine A and an acid capable of forming a salt with it, and a preparation method thereof . Background technique [0002] Huperzine A is a highly efficient and highly selective central acetylcholinesterase inhibitor extracted from Chinese herbal medicine Huperzia serrata. It has selective inhibitory effect on true acetylcholinesterase, easily passes through the blood-brain barrier, and has a long acting time. It has the effect of promoting memory reproduction and enhancing memory retention. In 1985, the injection was first developed in China for myasthenia gravis, and later it was also used clinically to treat senile dementia, benign memory impairment and other diseases. It is currently FDA-a...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K31/439A61P25/28
Inventor 赵守明谢正生林红
Owner ZHEJIANG WANBANG PHARMA
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