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Compound amino acid injection composition suitable for kidney disease patient

A compound amino acid and composition technology, which is applied in the direction of drug combination, active ingredients of anhydride/acid/halide, pharmaceutical formula, etc., can solve the problems of low, neglected, and unreasonable content of essential amino acids, and achieve the purpose of improving nutritional status and correcting negative Nitrogen balance, the effect of correcting amino acid imbalance state

Active Publication Date: 2008-02-13
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] From the perspective of prescription composition, the prescription design of Compound Amino Acid Injection (9AA) is reasonable but also unreasonable
The rationality is reflected in the fact that the prescription takes into account the low content of essential amino acids in such patients, and the unreasonable aspect is that it completely ignores the needs of such patients for non-essential amino acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Weigh each amino acid raw material according to the following table:

[0065] Ingredients Content

[0066] L-Isoleucine 4.08g

[0067] L-Leucine 8.24g

[0068] L-lysine acetate 8.008g

[0069] L-Methionine 2.24g

[0070] Acetylcysteine ​​0.4 g

[0071] L-Phenylalanine 3.04g

[0072] L-Threonine 3.84g

[0073] L-Tryptophan 1.52g

[0074] L-Valine 4.96g

[0075] L-Arginine 3.92g

[0076] L-histidine 3.44 g

[0077] Glycine 2.56 g

[0078] L-alanine 5.04g

[0079] L-Proline 3.44g

[0080] L-serine 3.6g

[0081] L-malic acid 1.2g

[0082] Rinse all production equipment with water for injection. During the whole production process, the product must be protected by nitrogen gas filtered with a pore size of 0.22 μm.

[0083] Put the weighed amino acid raw material into the preparation tank. Vacuum the preparation tank until the vacuum degree reaches more than 80%, and then fill it with nitrogen to positive pressure after vacuuming.

[0084] Under the protectio...

Embodiment 2

[0091] Weigh each amino acid raw material according to the following table:

[0092] Ingredient Weight

[0093] L-Isoleucine 5.10g

[0094] L-Leucine 10.30g

[0095] L-Lysine Acetate 10.01g

[0096] L-Methionine 2.80g

[0097] Acetylcysteine ​​0.50 g

[0098] L-Phenylalanine 3.80g

[0099] L-Threonine 4.80g

[0100] L-Tryptophan 1.90g

[0101] L-Valine 6.20g

[0102] L-Arginine 4.90g

[0103] L-Histidine 4.30g

[0104] Glycine 3.20 g

[0105] L-alanine 6.30g

[0106] L-Proline 4.30g

[0107] L-serine 4.50g

[0108] L-malic acid 1.50g

[0109] Rinse all production equipment with water for injection. During the whole production process, the product must be protected by nitrogen gas filtered with a pore size of 0.22 μm.

[0110] Put the weighed amino acid raw material into the preparation tank. Vacuum the preparation tank until the vacuum degree reaches more than 80%, and then fill it with nitrogen to positive pressure after vacuuming.

[0111] Under the protecti...

Embodiment 3

[0118] Weigh each amino acid raw material according to the following table:

[0119] Ingredient Weight

[0120] L-Isoleucine 6.12g

[0121] L-Leucine 12.36g

[0122] L-lysine acetate 12.012g

[0123] L-Methionine 3.36g

[0124] Acetylcysteine ​​0.6g

[0125] L-Phenylalanine 4.56g

[0126] L-Threonine 5.76g

[0127] L-Tryptophan 2.28g

[0128] L-Valine 7.44g

[0129] L-Arginine 5.88g

[0130] L-Histidine 5.16g

[0131] Glycine 3.84 g

[0132] L-alanine 7.56g

[0133] L-Proline 5.16g

[0134] L-serine 5.4g

[0135] L-malic acid 1.8g

[0136] Rinse all production equipment with water for injection. During the whole production process, the product must be protected by nitrogen gas filtered with a pore size of 0.22 μm.

[0137] Put the weighed amino acid raw material into the preparation tank. Vacuum the preparation tank until the vacuum degree reaches more than 80%, and then fill it with nitrogen to positive pressure after vacuuming.

[0138] Under the protection of...

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PUM

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Abstract

The invention relates to a compound amino acid injection composition and a preparation method thereof. The injection is characterized in that: besides the essential amino acids for human body, the prescription also contains non-essential amino acids that cannot be synthesized in the body or are insufficiently synthesized in the condition of kidney disease. The preparation of the compound amino acid injection under the condition of strictly controlling the aerobic environment can make the product meet the quality requirements without any antioxidant. This product is suitable for patients with kidney disease and meets their special requirements for various essential and non-essential amino acids. It not only balances the amino acid content in the patient's body, but also supplements nutrition; no antioxidants are added to the prescription, which can effectively reduce the occurrence of adverse reactions in clinical application Rate.

Description

technical field [0001] The invention discloses a compound amino acid injection composition containing 15 kinds of amino acids and a preparation method thereof. The prescription of the compound amino acid injection composition is suitable for kidney disease patients. Background technique [0002] Acute renal failure is a clinical syndrome characterized by a sharp decrease in renal excretory function and a serious disorder in the internal environment of the body caused by various reasons. In acute renal failure, the body is in a state of stress, and catabolism is greater than anabolism. Kidney function drops sharply, and toxins accumulate in the body, causing symptoms of poisoning in various systems throughout the body. Among them, gastrointestinal symptoms appear first, such as loss of appetite, nausea, vomiting, diarrhea, etc., which reduce the daily intake of nutrients and stimulate the body to consume its own reserves and use protein and fat for energy. Acute renal failu...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/198A61K31/19A61K31/401A61K31/405A61K31/4172A61P13/12
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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