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Compound amino acid injection composition suitable for kidney disease patient

A compound amino acid and composition technology, which can be used in drug combinations, anhydride/acid/halide active ingredients, and pharmaceutical formulations, etc., can solve the problems of low, unreasonable, and neglected content of essential amino acids, so as to improve nutritional status and correct negative effects. Nitrogen balance, the effect of correcting amino acid imbalance

Active Publication Date: 2010-06-16
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] From the perspective of prescription composition, the prescription design of Compound Amino Acid Injection (9AA) is reasonable but also unreasonable
The rationality is reflected in the fact that the prescription takes into account the low content of essential amino acids in such patients, and the unreasonable aspect is that it completely ignores the needs of such patients for non-essential amino acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Weigh each amino acid raw material according to the following table:

[0065] Ingredients Content

[0066] L-Isoleucine 4.08g

[0067] L-Leucine 8.24g

[0068] L-lysine acetate 8.008g

[0069] L-Methionine 2.24g

[0070] Acetylcysteine ​​0.4 g

[0071] L-Phenylalanine 3.04g

[0072] L-Threonine 3.84g

[0073] L-Tryptophan 1.52g

[0074] L-Valine 4.96g

[0075] L-Arginine 3.92g

[0076] L-histidine 3.44 g

[0077] Glycine 2.56 g

[0078] L-alanine 5.04g

[0079] L-Proline 3.44g

[0080] L-serine 3.6g

[0081] L-malic acid 1.2g

[0082] Rinse all production equipment with water for injection. During the whole production process, the product must be protected by nitrogen gas filtered with a pore size of 0.22 μm.

[0083] Put the weighed amino acid raw material into the preparation tank. Vacuum the preparation tank until the vacuum degree reaches more than 80%, and then fill it with nitrogen to positive pressure after vacuuming.

[0084] Under the protectio...

Embodiment 2

[0091] Weigh each amino acid raw material according to the following table:

[0092] Ingredient Weight

[0093] L-Isoleucine 5.10g

[0094] L-Leucine 10.30g

[0095] L-Lysine Acetate 10.01g

[0096] L-Methionine 2.80g

[0097] Acetylcysteine ​​0.50 g

[0098] L-Phenylalanine 3.80g

[0099] L-Threonine 4.80g

[0100] L-Tryptophan 1.90g

[0101] L-Valine 6.20g

[0102] L-Arginine 4.90g

[0103] L-Histidine 4.30g

[0104] Glycine 3.20 g

[0105] L-alanine 6.30g

[0106] L-Proline 4.30g

[0107] L-serine 4.50g

[0108] L-malic acid 1.50g

[0109] Rinse all production equipment with water for injection. During the whole production process, the product must be protected by nitrogen gas filtered with a pore size of 0.22 μm.

[0110] Put the weighed amino acid raw material into the preparation tank. Vacuum the preparation tank until the vacuum degree reaches more than 80%, and then fill it with nitrogen to positive pressure after vacuuming.

[0111] Under the protecti...

Embodiment 3

[0118] Weigh each amino acid raw material according to the following table:

[0119] Ingredient Weight

[0120] L-Isoleucine 6.12g

[0121] L-Leucine 12.36g

[0122] L-lysine acetate 12.012g

[0123] L-Methionine 3.36g

[0124] Acetylcysteine ​​0.6g

[0125] L-Phenylalanine 4.56g

[0126] L-Threonine 5.76g

[0127] L-Tryptophan 2.28g

[0128] L-Valine 7.44g

[0129] L-Arginine 5.88g

[0130] L-Histidine 5.16g

[0131] Glycine 3.84 g

[0132] L-alanine 7.56g

[0133] L-Proline 5.16g

[0134] L-serine 5.4g

[0135] L-malic acid 1.8g

[0136] Rinse all production equipment with water for injection. During the whole production process, the product must be protected by nitrogen gas filtered with a pore size of 0.22 μm.

[0137] Put the weighed amino acid raw material into the preparation tank. Vacuum the preparation tank until the vacuum degree reaches more than 80%, and then fill it with nitrogen to positive pressure after vacuuming.

[0138] Under the protection of...

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PUM

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Abstract

The present invention comprises a compound amino acid injection and the preparation method. The characteristics of the injection are as follows. The prescription comprises most human essential amino acid and non essential amino acid. The present invention also contains non essential amino acid with insufficient quantity or incapable of production in the body for kidney disease. The compound aminoacid injection is prepared under strict control of aerobic environment, which makes the product in accordance with quality requirements without any antioxidant. The production is applicable in the patients with kidney disease, which is in accordance with specific requirement for AAA restriction. No antioxidant is added in the prescription, which can effectively reduce incidence rate of adverse reaction in clinical application.

Description

technical field [0001] The invention discloses a compound amino acid injection composition containing 15 kinds of amino acids and a preparation method thereof. The prescription of the compound amino acid injection composition is suitable for kidney disease patients. Background technique [0002] Acute renal failure is a clinical syndrome characterized by a sharp decrease in renal excretory function and a serious disorder in the internal environment of the body caused by various reasons. In acute renal failure, the body is in a state of stress, and catabolism is greater than anabolism. Kidney function drops sharply, and toxins accumulate in the body, causing symptoms of poisoning in various systems throughout the body. Among them, gastrointestinal symptoms appear first, such as loss of appetite, nausea, vomiting, diarrhea, etc., which reduce the daily intake of nutrients and stimulate the body to consume its own reserves and use protein and fat for energy. Acute renal failu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/198A61K31/19A61K31/401A61K31/405A61K31/4172A61P13/12
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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