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Fingerprint quality control method of gynostemma pentaphylla medicine added with internal standard

A quality control method and fingerprint technology, applied in the field of quality control of Gynostemma pentaphyllum raw materials, can solve the problems of inaccurate identification and evaluation of Gynostemma pentaphyllum medicinal materials, and meet the needs of medicinal material identification and quality control, with strong specificity and stable relative retention time Effect

Active Publication Date: 2007-11-28
SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In terms of the quality evaluation of Gynostemma pentaphyllum medicinal material, in the literature published at home and abroad at present, colorimetric method or TLC scanning method are generally used to measure the total saponins of Gynostemma pentaphyllum, and it is used as the quality evaluation index of Gynostemma pentaphylla medicinal material. Obviously, this quality evaluation method cannot Accurate Identification and Evaluation of Gynostemma Gynostemma

Method used

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  • Fingerprint quality control method of gynostemma pentaphylla medicine added with internal standard
  • Fingerprint quality control method of gynostemma pentaphylla medicine added with internal standard
  • Fingerprint quality control method of gynostemma pentaphylla medicine added with internal standard

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Experimental method

[0039] Reagent name

level

manufacturer

HZ-818 macroporous adsorption resin

AB-8 type macroporous adsorption resin

Methanol

pure water

Acetonitrile

95% ethanol

Gynostemma

Analytical pure

Chromatographically pure

industrial grade

Shanghai Huazhen Technology Trading Company

Nankai University

Shanghai Zhenxing Chemical Plant No. 1

Coca-Cola Company

Tedia

Shaanxi

[0040] 1.2 Instruments

[0041] name

model

manufacturer

Electronic balance

High performance liquid chromatography

Column thermostat

Chinese medicine grinder

Microporous membrane

High speed centrifuge

sieve

ultrasonic cleaner

Rotary evaporator

Circulating water multi-purpose vacuum pump

Glass chromatography column

Convection pump

AL104 type

HP1100

HT-130 type

0.45...

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PUM

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Abstract

The invention relates to a quality control method for fingerprint of herba gynostemae medicinal materials with internal standard in it, comprising (1) measuring method for fingerprint of herba gynostemae medicinal material, (2) building standard fingerprint, (3) comparing HPLC fingerprint of sample with reference fingerprint according to technology demand of quality control of fingerprint that similarity of six common peaks calculated is not smaller than 0.9. The invention is provided with high sensitivity, good reproducibility, strong specialization and reliable method. It can evaluate quality of herba gynostemae medical material scientifically and effectively. It can be applied in quality control in practical production and can satisfy the demand of identification and quality control for enterprise medicinal material.

Description

technical field [0001] The invention belongs to the field of quality control methods for Gynostemma pentaphyllum raw materials, in particular to a method for quality control of the fingerprints of Gynostemma pentaphylla medicinal material by adding an internal standard to herbal medicines for strengthening the body and removing blood stasis. Background technique [0002] Jiaogulan (Gynostemma pentaphfllum (Thunb) Makino.) is a perennial vine herb, which is a model plant of the genus Jiaogulan in Cucurbitaceae. It was first published in "Rescue Famine Materia Medica". Traditional Chinese medicine believes that Gynostemma pentaphyllum is bitter in taste, cold in nature, non-toxic, and has the functions of clearing heat and detoxifying, relieving cough and reducing phlegm, invigorating qi and promoting body fluid, strengthening the spleen and calming the nerves. Modern pharmacology has proved that Gynostemma pentaphyllum has pharmacological effects such as inhibiting tumors, p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/88G01N33/15
Inventor 胡坪潘一峰
Owner SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECH DEV
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