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Valsartan and Hydrochlorothiade pills, and preparation method

A technology of tan hydrochlorothiazide and hydrochlorothiazide, which is applied in the field of valsartan hydrochlorothiazide drop pills and its preparation, can solve the problems of unfavorable swallowing difficulties, low bioavailability, unstable quality, etc., and achieve improved bioavailability and bioavailability High degree of dust pollution reduction effect

Inactive Publication Date: 2007-10-10
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology and dosage forms, such oral preparations have disadvantages such as long disintegration time, slow onset of action, and low bioavailability, which affect the full play of the drug effect.
During storage, it is easy to split, change color, absorb moisture, etc., and the quality is unstable
It is also not suitable for patients with swallowing difficulties

Method used

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  • Valsartan and Hydrochlorothiade pills, and preparation method
  • Valsartan and Hydrochlorothiade pills, and preparation method
  • Valsartan and Hydrochlorothiade pills, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: In this example, the formulation of valsartan, hydrochlorothiazide and a single matrix is ​​used, and the preparation method in [specific implementation] is operated, the coolant is simethicone oil, dripping pills are made, and the roundness and pill weight are selected Difference, hardness, dissolving time etc. are index, observe the influence of the weight ratio of medicine and single matrix on the product involved in the present invention, test result is shown in Table 1.

[0033] Table 1 Tests of drug and single matrix formulation (all drugs are 1 part)

[0034]

[0035] Note: 1. The coolant is simethicone oil, and the cooling temperature is 3-5°C; the heat preservation temperature of the drug material and the dripper is 85-90°C; the dripping speed is 30-50 grains / minute.

[0036] 2. The above results show that the indicators of Nos. 3, 4, 5, 7, 8, 9, and 10 are better, that is, when the ratio of drug to matrix is ​​1:2-1:9, it can be dripp...

Embodiment 2

[0037] Example 2: In this example, through the formula of valsartan, hydrochlorothiazide and mixed matrix, operate according to the preparation method in [specific implementation mode], the coolant is simethicone oil, and drop pills are made, and the roundness and pill weight are selected. Difference, hardness, dissolving time etc. are investigation indexes, observe the influence of the weight ratio of medicine and mixed matrix on the product involved in the present invention, test result is shown in Table 2.

[0038] Table 2 Drug and mixed matrix formulation test (1 part of drug)

[0039]

[0040] Note: 1. The coolant is simethicone oil, and the cooling temperature is 8-5°C; the heat preservation temperature of the drug material and the dripper is 85-90°C; the dripping speed is 30-50 grains / minute.

[0041] 2. The above results show that the indicators of No. 2, 3, 5, 6, 8, 9, 11, and 12 tests are all good, that is, when the ratio of drug to matrix is ​​1:1-1:9, ...

Embodiment 3

[0042] Embodiment 3: In this embodiment, different coolants are selected, and the coolant is simethicone, liquid paraffin, vegetable oil, and polyethylene glycol is selected as a single matrix 6000 , the mixed matrix chooses polyethylene glycol 6000: the formula of poloxamer=1:0.2, operate according to the preparation method in [the specific embodiment], drip dripping pill, select roundness, pill weight difference, hardness, dissolving time etc. as investigation index, observe different The impact of coolant on the products involved in the present invention, the test results are shown in Table 3.

[0043] Table 3 Experiments using different coolants (drug: matrix = 1:3)

[0044]

[0045] Note: 1. The cooling temperature is 8-5°C; the heat preservation and dripper temperature is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0046] 2. The above results show that the indicators of No. 1 and No. 2 tests are better, that is, when the above-mentioned differe...

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Abstract

A dripping pill of valsartan-hydrochrothiazide for treating hypertension is prepared from the valsartan, hydrochrothiazide and the matrix of dripping pill. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and particularly relates to a Valsartan-Hydrochrothiazide drop pill prepared from chemical raw materials Valsartan, Hydrochrothiazide and a drop pill matrix and a preparation method thereof. Background technique [0002] Hypertension is one of the most common cardiovascular diseases in the world today, and it is the leading cause of death and disability in adults. It is characterized by high prevalence, high disability, and high mortality. Among the hypertensive patients, a considerable number of patients cannot bring blood pressure down to normal with only one antihypertensive drug, and need to use two or more antihypertensive drugs to make blood pressure normal. Therefore, in order to facilitate clinical rational drug use, improve patient compliance, further develop the clinical application of drugs, improve the therapeutic effect of drugs, and improve the tolerance of drugs, two commonly used...

Claims

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Application Information

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IPC IPC(8): A61K31/41A61K31/549A61K9/20A61P9/12
Inventor 陈茜滕慧丽
Owner 陈茜
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