Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal composition containing ibuprofen

A composition and filling composition technology, applied in the field of new ibuprofen pharmaceutical composition, can solve the problems of crystallization, poor solubility, limited ibuprofen solubility, etc.

Active Publication Date: 2007-09-05
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ibuprofen is dissolved in polyethylene glycol (PEG) to make filling liquid, and try to make soft capsule, but this soft capsule still has serious defect, the one, the solubility of ibuprofen in polyethylene glycol is limited, If polyethylene glycol is used as a soft capsule prepared as a dispersion medium, crystallization often occurs during storage.
Second, because ibuprofen is insoluble in water, the solubility of ibuprofen in acidic medium or in gastric acid is even worse, so that the active ingredient released after the disintegration of the soft capsule made by this technology is rapidly formed in gastric juice Precipitation, absorption is greatly delayed, it is difficult to act quickly
[0004] In the 01817721.2 patent, it is said that adding terpenes to the filling liquid can reduce the crystallization of ibuprofen, but as a highly active ingredient, terpenes are easy to react with gelatin in soft capsules, resulting in soft capsules not collapsing solution, while terpenes are easily oxidized and may cause harm to the human body
Patent 01814778.X adopts the addition of strong base (sodium hydroxide or potassium hydroxide) in the filling solution. Although it can achieve the purpose of improving the solubility of ibuprofen, polyethylene glycol reacts with strong base to produce colored substances. Has certain toxicity to the human body, thus limiting the application of this patent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare the soft capsule preparation containing following composition:

[0019] Ibuprofen (S-Ibuprofen) 70g

[0020] Sodium ibuprofen (S-sodium ibuprofen) 33.2g

[0021] PEG400 100g

[0022] Under the condition of 60-85°C, mix and stir the above ingredients evenly to dissolve all the ibuprofen and ibuprofen sodium to obtain a clear filling solution, and press the prepared drug solution into pellets to make 1000 soft capsules, and set the shape , after drying.

Embodiment 2

[0024] Prepare the soft capsule preparation containing following composition:

[0025] Ibuprofen (S-Ibuprofen) 70g

[0026] Ibuprofen Potassium (S-Ibuprofen Potassium) 35.3g

[0027] PEG400 100g

[0028] Under the condition of 60~85℃, mix and stir the above ingredients evenly, fully dissolve the ibuprofen and ibuprofen potassium through sufficient stirring, and obtain a clear and transparent filling liquid, and press the prepared medicine liquid into pellets to make 1000 capsules Soft capsules, ready after being shaped and dried.

Embodiment 3

[0030] Prepare the soft capsule preparation containing following composition:

[0031] Ibuprofen (S-Ibuprofen) 100g

[0032] Ibuprofen Meglumine Salt 71.6g

[0033] PEG200 30g

[0034] PEG60070g

[0035] Under the condition of 60-85°C, mix and stir the above-mentioned ingredients evenly, fully dissolve the ibuprofen and the meglumine salt of ibuprofen through sufficient stirring, and obtain a clear and transparent filling liquid, and press the prepared medicinal liquid into pellets, Make 1000 soft capsules, get final product after being shaped and dried.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A composite medicine containing ibuprofen, which may be the free acid of ibuprofen, salt of ibuprofen, their combination, or the combination of ibuprofen and pseudoephedrine hydrochloride, is disclosed.

Description

technical field [0001] The present invention relates to a new pharmaceutical composition of ibuprofen, wherein ibuprofen can be free acid of ibuprofen, salt of ibuprofen or any combination thereof, or ibuprofen and medically acceptable A combination of doses of pseudoephedrine hydrochloride. The new composition overcomes the disadvantages of low bioavailability and long peak time of existing products, and improves the curative effect of the drug. Background technique [0002] Ibuprofen, namely 2-(4-isobutylphenyl)propionic acid, is one of the most widely used non-steroidal anti-inflammatory drugs in clinical practice, and has significant antipyretic, analgesic and anti-inflammatory properties. It is mainly used to treat various rheumatism and rheumatoid arthritis. It is suitable for relieving and relieving mild to moderate pains, such as headaches and sore limbs caused by colds, and others such as toothache, dysmenorrhea, and postoperative pain. The currently commonly used...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/192A61K31/198A61K9/20A61K9/48A61K47/34A61P29/00A61P19/02A61K31/137A61K47/10
Inventor 牛占旗陈震郭海波游红权孙晓伟
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com