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2-peroxo-vanadium-potassium salt complex, its preparing method and mono-crystal culture

A technology of potassium diperoxide and vanadium diperoxide, which is applied in the field of single crystal cultivation, and can solve problems such as lactic acidosis, poor absorption, and inability to administer insulin orally

Inactive Publication Date: 2011-03-23
XIANGTAN KAIYUAN CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, the widespread use of insulin and some oral blood sugar-regulating drugs has made great progress in the drug treatment of diabetes, but they also have some limitations: insulin cannot be administered orally; and oral sulfonylureas and biguanides, respectively. Toxic side effects of hypoglycemia and lactic acidosis
Using the current general-purpose Streptozotocin (Streptozotocin STZ) and Biobreeding (BB) diabetes models to do animal experiments, the results show that these vanadium-containing complexes have hypoglycemic effects, and some clinical experiments have also given positive results, but these complexes Poor absorption in the body and high toxicity and side effects, so people turn to the synthesis of other vanadium-containing complexes with strong activity, easy absorption, good water solubility, low toxicity and stability

Method used

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  • 2-peroxo-vanadium-potassium salt complex, its preparing method and mono-crystal culture
  • 2-peroxo-vanadium-potassium salt complex, its preparing method and mono-crystal culture
  • 2-peroxo-vanadium-potassium salt complex, its preparing method and mono-crystal culture

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Embodiment 1

[0023] Embodiment 1: the preparation of the complex described in the invention

[0024] Add 1.38g KVO to the beaker 3 and 10 mL of H 2 o 2 (30%), pending KVO 3 After disappearing, add 50 mL of water to the solution, and add 1.50 g of 2-(3′-pyrazole)-pyridine in an ice-water bath, continue stirring for 30 minutes in an ice-bath, and place the reaction solution at 2°C overnight, and orange Yellow crystals, the crystals were washed with a small amount of water and ethanol to obtain 2.0 g of fine granular pure product with a yield of about 50%.

Embodiment 2

[0025] Embodiment 2: The single crystal X-ray diffraction test conditions and results of the inventive complex are as follows:

[0026] The single crystal X-ray diffraction experiment was carried out on an Oxford diffractometer, using a Cu target of a graphite monochromator, the temperature was 150K, the voltage was 40kV, and the current was 40mA to collect independent diffraction points, and the complex diffraction intensity was calculated using the CryAlisProGemini utra System program The data was restored, while absorbance correction was performed. The SHELXS-97 and SHELXL-97 packages were used for structure analysis, hydrogenation and refinement, and all non-hydrogen atoms were analyzed using the Full-matrix least-squares refinement base on F 2 ) for structural refinement, and all non-hydrogen atoms for anisotropic refinement. Some other detailed information about the crystal is listed in Table 1 and Table 2.

[0027] Table 1 Complex K[OV(O 2 ) 2 {C 8 h 7 N 3}]·5H 2...

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Abstract

The invention relates to new bi-preoxy a vanadium complex that has the constitutional formula of formula 1. The complex molecular formula is C8H17KN3010V, and molecular weight is 405.29. The invention also relates to the potential application in curing diabetes.

Description

technical field [0001] The invention relates to a potassium bisperoxovanadium complex, a preparation method and single crystal cultivation of the complex. Background technique [0002] Diabetes mellitus is a common endocrine disease characterized by metabolic disorders of sugar, fat and protein caused by insufficient secretion or defective action of insulin in the body. In recent years, the number of diabetic patients in my country has exceeded 40 million. Diabetes has become a major disease that seriously threatens health in my country after cancer and cardiovascular disease. In recent years, the widespread use of insulin and some oral blood sugar-regulating drugs has made great progress in the drug treatment of diabetes, but they also have some limitations: insulin cannot be administered orally; and oral sulfonylureas and biguanides, respectively. It has toxic side effects of hypoglycemia and lactic acidosis. Therefore, finding new oral hypoglycemic agents with high effi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D401/04C07F9/00
Inventor 于贤勇李国斌易平贵黄昊文李霞曾云龙
Owner XIANGTAN KAIYUAN CHEM
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