Composition formed from chitosan and its derivatives and low-molecular heparin and pneparation and preparing method

A technology of low-molecular-weight heparin and chitosan, which is applied in the direction of medical preparations, drug combinations, and pharmaceutical formulations of non-active ingredients, can solve problems such as difficult gastrointestinal mucosal absorption, poor patient compliance, and large molecular weight, and achieve reduction Effects of side effects, improvement of curative effect, and stability improvement

Inactive Publication Date: 2007-08-29
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, LMWH is still difficult to absorb through the gastrointestinal mucosa due to its large molecular weight, multiple hydrogen bonds, and negatively charged structural characteristics. Currently, it can only be administered clinically by intravenous or intramuscular injection, and frequent administration is required. , poor patient compliance
It is also extremely inconvenient for patients to take medication after discharge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of low-molecular-weight heparin and chitosan nano / micro-composites with different molecular weights: weigh chitosan with different molecular weights according to the above ratio to make a solution of appropriate concentration, and weigh low-molecular heparin according to the above ratio to make a suitable solution. The solution of the above concentration is added into the above-mentioned chitosan solution under the condition of stirring, the stirring is continued for 10 minutes, the stirring is stopped, and the solution is incubated at room temperature for 30 minutes to obtain the final product.

Embodiment 2

[0017] Example 2: Preparation of low-molecular-weight heparin and trimethyl chitosan nano / micro composites of different molecular weights: take trimethyl chitosan with different molecular weights according to the above ratio to make a solution of appropriate concentration, and weigh according to the above ratio Low-molecular-weight heparin is prepared into a solution with an appropriate concentration, added into the above-mentioned trimethyl chitosan solution under agitation, continued to agitate for 10 minutes, stopped agitation, and incubated at room temperature for 30 minutes to obtain the product.

Embodiment 3

[0018] Embodiment 3: Preparation of low molecular weight heparin and chitosan nano / micro composites of different molecular weight pegylated chitosan: take the chitosan of different molecular weight pegylated according to the above ratio to make a solution of appropriate concentration, press The above ratio is weighed with low molecular weight heparin to prepare a solution of appropriate concentration, added to the above-mentioned PEGylated chitosan solution under stirring conditions, continued to stir for 10 minutes, stopped stirring, and incubated at room temperature for 30 minutes to obtain.

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PUM

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Abstract

The present invention belongs to the field of medicine technology. In particular, it relates to a compound made up by using chitosan, its derivative and low-molecular heparin, its preparation and preparation method. Said compound can raise stability of low-molecular heparin, and can further raise bioavailability of said medicine preparation. Said compound can be made into various oral preparations, injection, spray, nose drops, aerosol and suppository, etc.

Description

technical field [0001] The invention relates to the technical field of medicine, specifically, the nano / micro complex formed by chitosan and its derivatives and low-molecular-weight heparin is used as a carrier to increase the uptake of low-molecular-weight heparin by cells, and the use of chitosan and its derivatives The characteristics of bioadhesion and short-term opening of tight junctions between cells further increase the amount of low-molecular-weight heparin passing through the biomembrane, improve the stability of low-molecular-weight heparin through the formation of complexes, and provide clinical medicine by making different preparations. convenience. Background technique [0002] Low-molecular-weight heparin (LMWH) is a low-molecular-weight heparin fragment obtained by heparin degradation or a low-molecular-weight heparin component obtained by fractionation. It is a polysaccharide composed of alternating residue chains of D-glucosamine and uronic acid. The relat...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/727A61K47/36A61K47/38A61K9/00A61P7/02A61P9/00A61P11/00A61K47/61
Inventor 毛世瑞
Owner SHENYANG PHARMA UNIVERSITY
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