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Ph-dependent composite bone peptide preparation, preparing method and use thereof

A dependent, osteopeptide-based technology, applied in pill delivery, bone diseases, drug combinations, etc., can solve the problems of loss of biological activity, patients can not accept injections, etc., to maintain biological activity, prevent osteoporosis, improve The effect of bioavailability

Active Publication Date: 2007-08-15
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, all osteopeptide drugs sold in the pharmaceutical market are injections, and the prevention and treatment of osteoporosis is a long-term task, and patients cannot accept daily injections
Compound bone peptide plays an important role in the prevention and treatment of osteoporosis, but after oral administration, it is hydrolyzed by gastric acid and degraded by digestive enzymes in the digestive tract, and loses its biological activity, which is the biggest difficulty encountered in oral administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Get animal limb bone powder 100kg and cucumber seed powder 100kg;

[0076] 1. The method of raw material pretreatment

[0077] Animal limb bones with muscles and fascia removed, cucumber seeds without sand, stones and sundries are taken, washed with normal water, rinsed with distilled water, pasteurized, dried, crushed to 10-20 mesh, and stored in a cold storage for future use.

[0078] 2. Extract compound bone peptide

[0079] Add 800kg of pure water to a stainless steel extraction tank, heat to 70°C, stir with air flow, add animal bone powder and cucumber seed powder, adjust the pH to 5.5-6, add 200g of pepsin and 50g of subtilisin into a small amount of pure water to dissolve, and stir Add it to the extraction tank, react for 3 hours, centrifuge, and filter the supernatant through a membrane filter.

[0080] 3. Concentrate

[0081] The filtrate is placed in a concentration tank, concentrated in vacuum at a temperature of 75-80°C, and concentrated to a specific gra...

Embodiment 2

[0090] Get 70kg of salvia miltiorrhiza to replace cucumber seeds, and all the other raw materials and weight ratios are the same as in Example 1, and the preparation method is also the same.

Embodiment 3

[0091] Embodiment three: get Epimedium 80kg, replace cucumber seed, all the other raw materials and weight ratio are all the same as embodiment one, and preparation method is also the same.

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PUM

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Abstract

This invention relates to a pH dependent compound bone peptide preparation and its preparation method and application. The preparation method comprises carrying out pretreatment of animal bones of limbs powder and cucumber seed powder, extracting compound bone peptide, concentrating, clathrating with beta-cyclodextrin, and making into colon-specific slow release capsule or tablet in order to avoid gastric juice hydrolysis and hepatic first pass effect to destroy its bioactivity. The compound bone peptide has a molecular weight below 5000 Daitor, and can be used for preventing fracture and osteoporosis, treating ostalgia, rheumatism and rheumatoid diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines and health care products, and in particular the invention relates to a pH-dependent composite bone peptide preparation and its preparation method and application. Background technique [0002] Osteoporosis is a systemic disease characterized by decreased bone density, microarchitecture and ultrastructural destruction of bone tissue, resulting in increased bone fragility. In the life cycle of the human body, bone is constantly formed and destroyed, maintaining a dynamic balance. Factors such as hormone deficiency, malnutrition, disease and drugs, and reduced exercise can disrupt the dynamic balance of osteoblasts and osteoclasts, leading to osteoporosis. Therefore, it is a misunderstanding to simply supplement calcium to prevent and treat osteoporosis. [0003] At present, all osteopeptide drugs sold in the pharmaceutical market are injections, and the prevention and treatment of osteoporosis i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K36/537A61K36/46A61K36/296A61K36/234A61K38/02A61K38/48A61K9/20A61K9/48A61P19/10A61K35/32
Inventor 李延平崔燎邓亦峰
Owner GUANGDONG MEDICAL UNIV
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